Dynamic changes in the epigenomic landscape regulate human organogenesis and link to developmental disorders

How the epigenomic landscape linked to transcription regulates human embryonic development is unclear. Here, the authors analyse the dynamics of H3K27Ac, H3K4me3 and H3K27me3 during the period when organs first assemble as a platform for understanding noncoding developmental disorders.

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Detalles Bibliográficos
Autores principales:	Dave T. Gerrard, Andrew A. Berry, Rachel E. Jennings, Matthew J. Birket, Peyman Zarrineh, Myles G. Garstang, Sarah L. Withey, Patrick Short, Sandra Jiménez-Gancedo, Panos N. Firbas, Ian Donaldson, Andrew D. Sharrocks, Karen Piper Hanley, Matthew E. Hurles, José Luis Gomez-Skarmeta, Nicoletta Bobola, Neil A. Hanley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a296a0ec6d0e434aa7dff480689080a7
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spelling	oai:doaj.org-article:a296a0ec6d0e434aa7dff480689080a72021-12-02T14:53:44ZDynamic changes in the epigenomic landscape regulate human organogenesis and link to developmental disorders10.1038/s41467-020-17305-22041-1723https://doaj.org/article/a296a0ec6d0e434aa7dff480689080a72020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17305-2https://doaj.org/toc/2041-1723How the epigenomic landscape linked to transcription regulates human embryonic development is unclear. Here, the authors analyse the dynamics of H3K27Ac, H3K4me3 and H3K27me3 during the period when organs first assemble as a platform for understanding noncoding developmental disorders.Dave T. GerrardAndrew A. BerryRachel E. JenningsMatthew J. BirketPeyman ZarrinehMyles G. GarstangSarah L. WitheyPatrick ShortSandra Jiménez-GancedoPanos N. FirbasIan DonaldsonAndrew D. SharrocksKaren Piper HanleyMatthew E. HurlesJosé Luis Gomez-SkarmetaNicoletta BobolaNeil A. HanleyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dave T. Gerrard Andrew A. Berry Rachel E. Jennings Matthew J. Birket Peyman Zarrineh Myles G. Garstang Sarah L. Withey Patrick Short Sandra Jiménez-Gancedo Panos N. Firbas Ian Donaldson Andrew D. Sharrocks Karen Piper Hanley Matthew E. Hurles José Luis Gomez-Skarmeta Nicoletta Bobola Neil A. Hanley Dynamic changes in the epigenomic landscape regulate human organogenesis and link to developmental disorders
description	How the epigenomic landscape linked to transcription regulates human embryonic development is unclear. Here, the authors analyse the dynamics of H3K27Ac, H3K4me3 and H3K27me3 during the period when organs first assemble as a platform for understanding noncoding developmental disorders.
format	article
author	Dave T. Gerrard Andrew A. Berry Rachel E. Jennings Matthew J. Birket Peyman Zarrineh Myles G. Garstang Sarah L. Withey Patrick Short Sandra Jiménez-Gancedo Panos N. Firbas Ian Donaldson Andrew D. Sharrocks Karen Piper Hanley Matthew E. Hurles José Luis Gomez-Skarmeta Nicoletta Bobola Neil A. Hanley
author_facet	Dave T. Gerrard Andrew A. Berry Rachel E. Jennings Matthew J. Birket Peyman Zarrineh Myles G. Garstang Sarah L. Withey Patrick Short Sandra Jiménez-Gancedo Panos N. Firbas Ian Donaldson Andrew D. Sharrocks Karen Piper Hanley Matthew E. Hurles José Luis Gomez-Skarmeta Nicoletta Bobola Neil A. Hanley
author_sort	Dave T. Gerrard
title	Dynamic changes in the epigenomic landscape regulate human organogenesis and link to developmental disorders
title_short	Dynamic changes in the epigenomic landscape regulate human organogenesis and link to developmental disorders
title_full	Dynamic changes in the epigenomic landscape regulate human organogenesis and link to developmental disorders
title_fullStr	Dynamic changes in the epigenomic landscape regulate human organogenesis and link to developmental disorders
title_full_unstemmed	Dynamic changes in the epigenomic landscape regulate human organogenesis and link to developmental disorders
title_sort	dynamic changes in the epigenomic landscape regulate human organogenesis and link to developmental disorders
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a296a0ec6d0e434aa7dff480689080a7
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Dynamic changes in the epigenomic landscape regulate human organogenesis and link to developmental disorders

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