CryoEM structure of adenovirus type 3 fibre with desmoglein 2 shows an unusual mode of receptor engagement

Human adenoviruses (HAd) cause respiratory, gastrointestinal and ocular infections. Here, the authors provide insights into the early stages of adenovirus infection by determining the cryo-EM structure of the trimeric HAd type 3 fibre knob bound to its cellular receptor human desmoglein 2, which rev...

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Autores principales:	Emilie Vassal-Stermann, Gregory Effantin, Chloe Zubieta, Wim Burmeister, Frédéric Iseni, Hongjie Wang, André Lieber, Guy Schoehn, Pascal Fender
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a29b63db80f642108a5689dd447f06e6
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spelling	oai:doaj.org-article:a29b63db80f642108a5689dd447f06e62021-12-02T16:58:25ZCryoEM structure of adenovirus type 3 fibre with desmoglein 2 shows an unusual mode of receptor engagement10.1038/s41467-019-09220-y2041-1723https://doaj.org/article/a29b63db80f642108a5689dd447f06e62019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09220-yhttps://doaj.org/toc/2041-1723Human adenoviruses (HAd) cause respiratory, gastrointestinal and ocular infections. Here, the authors provide insights into the early stages of adenovirus infection by determining the cryo-EM structure of the trimeric HAd type 3 fibre knob bound to its cellular receptor human desmoglein 2, which reveals residues critical for HAd-receptor interactions.Emilie Vassal-StermannGregory EffantinChloe ZubietaWim BurmeisterFrédéric IseniHongjie WangAndré LieberGuy SchoehnPascal FenderNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emilie Vassal-Stermann Gregory Effantin Chloe Zubieta Wim Burmeister Frédéric Iseni Hongjie Wang André Lieber Guy Schoehn Pascal Fender CryoEM structure of adenovirus type 3 fibre with desmoglein 2 shows an unusual mode of receptor engagement
description	Human adenoviruses (HAd) cause respiratory, gastrointestinal and ocular infections. Here, the authors provide insights into the early stages of adenovirus infection by determining the cryo-EM structure of the trimeric HAd type 3 fibre knob bound to its cellular receptor human desmoglein 2, which reveals residues critical for HAd-receptor interactions.
format	article
author	Emilie Vassal-Stermann Gregory Effantin Chloe Zubieta Wim Burmeister Frédéric Iseni Hongjie Wang André Lieber Guy Schoehn Pascal Fender
author_facet	Emilie Vassal-Stermann Gregory Effantin Chloe Zubieta Wim Burmeister Frédéric Iseni Hongjie Wang André Lieber Guy Schoehn Pascal Fender
author_sort	Emilie Vassal-Stermann
title	CryoEM structure of adenovirus type 3 fibre with desmoglein 2 shows an unusual mode of receptor engagement
title_short	CryoEM structure of adenovirus type 3 fibre with desmoglein 2 shows an unusual mode of receptor engagement
title_full	CryoEM structure of adenovirus type 3 fibre with desmoglein 2 shows an unusual mode of receptor engagement
title_fullStr	CryoEM structure of adenovirus type 3 fibre with desmoglein 2 shows an unusual mode of receptor engagement
title_full_unstemmed	CryoEM structure of adenovirus type 3 fibre with desmoglein 2 shows an unusual mode of receptor engagement
title_sort	cryoem structure of adenovirus type 3 fibre with desmoglein 2 shows an unusual mode of receptor engagement
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a29b63db80f642108a5689dd447f06e6
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CryoEM structure of adenovirus type 3 fibre with desmoglein 2 shows an unusual mode of receptor engagement

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