N-protein presents early in blood, dried blood and saliva during asymptomatic and symptomatic SARS-CoV-2 infection

N-protein presents early in blood, dried blood and saliva during asymptomatic and symptomatic SARS-CoV-2 infection

Here the authors develop a single molecule array (Simoa) immunoassay for detection of SARS-CoV-2 nucleocapsid protein in venous and dried capillary blood as well as saliva. The assay shows good performance in symptomatic, asymptomatic, and pre-symptomatic PCR+ individuals.

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Autores principales: Dandan Shan, Joseph M. Johnson, Syrena C. Fernandes, Hannah Suib, Soyoon Hwang, Danica Wuelfing, Muriel Mendes, Marcella Holdridge, Elaine M. Burke, Katie Beauregard, Ying Zhang, Megan Cleary, Samantha Xu, Xiao Yao, Purvish P. Patel, Tatiana Plavina, David H. Wilson, Lei Chang, Kim M. Kaiser, Jacob Nattermann, Susanne V. Schmidt, Eicke Latz, Kevin Hrusovsky, Dawn Mattoon, Andrew J. Ball
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/a29c0aa5590d40f2b3a8c214e47a4425
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spelling oai:doaj.org-article:a29c0aa5590d40f2b3a8c214e47a44252021-12-02T11:44:50ZN-protein presents early in blood, dried blood and saliva during asymptomatic and symptomatic SARS-CoV-2 infection10.1038/s41467-021-22072-92041-1723https://doaj.org/article/a29c0aa5590d40f2b3a8c214e47a44252021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22072-9https://doaj.org/toc/2041-1723Here the authors develop a single molecule array (Simoa) immunoassay for detection of SARS-CoV-2 nucleocapsid protein in venous and dried capillary blood as well as saliva. The assay shows good performance in symptomatic, asymptomatic, and pre-symptomatic PCR+ individuals.Dandan ShanJoseph M. JohnsonSyrena C. FernandesHannah SuibSoyoon HwangDanica WuelfingMuriel MendesMarcella HoldridgeElaine M. BurkeKatie BeauregardYing ZhangMegan ClearySamantha XuXiao YaoPurvish P. PatelTatiana PlavinaDavid H. WilsonLei ChangKim M. KaiserJacob NattermannSusanne V. SchmidtEicke LatzKevin HrusovskyDawn MattoonAndrew J. BallNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Dandan Shan
Joseph M. Johnson
Syrena C. Fernandes
Hannah Suib
Soyoon Hwang
Danica Wuelfing
Muriel Mendes
Marcella Holdridge
Elaine M. Burke
Katie Beauregard
Ying Zhang
Megan Cleary
Samantha Xu
Xiao Yao
Purvish P. Patel
Tatiana Plavina
David H. Wilson
Lei Chang
Kim M. Kaiser
Jacob Nattermann
Susanne V. Schmidt
Eicke Latz
Kevin Hrusovsky
Dawn Mattoon
Andrew J. Ball
N-protein presents early in blood, dried blood and saliva during asymptomatic and symptomatic SARS-CoV-2 infection
description Here the authors develop a single molecule array (Simoa) immunoassay for detection of SARS-CoV-2 nucleocapsid protein in venous and dried capillary blood as well as saliva. The assay shows good performance in symptomatic, asymptomatic, and pre-symptomatic PCR+ individuals.
format article
author Dandan Shan
Joseph M. Johnson
Syrena C. Fernandes
Hannah Suib
Soyoon Hwang
Danica Wuelfing
Muriel Mendes
Marcella Holdridge
Elaine M. Burke
Katie Beauregard
Ying Zhang
Megan Cleary
Samantha Xu
Xiao Yao
Purvish P. Patel
Tatiana Plavina
David H. Wilson
Lei Chang
Kim M. Kaiser
Jacob Nattermann
Susanne V. Schmidt
Eicke Latz
Kevin Hrusovsky
Dawn Mattoon
Andrew J. Ball
author_facet Dandan Shan
Joseph M. Johnson
Syrena C. Fernandes
Hannah Suib
Soyoon Hwang
Danica Wuelfing
Muriel Mendes
Marcella Holdridge
Elaine M. Burke
Katie Beauregard
Ying Zhang
Megan Cleary
Samantha Xu
Xiao Yao
Purvish P. Patel
Tatiana Plavina
David H. Wilson
Lei Chang
Kim M. Kaiser
Jacob Nattermann
Susanne V. Schmidt
Eicke Latz
Kevin Hrusovsky
Dawn Mattoon
Andrew J. Ball
author_sort Dandan Shan
title N-protein presents early in blood, dried blood and saliva during asymptomatic and symptomatic SARS-CoV-2 infection
title_short N-protein presents early in blood, dried blood and saliva during asymptomatic and symptomatic SARS-CoV-2 infection
title_full N-protein presents early in blood, dried blood and saliva during asymptomatic and symptomatic SARS-CoV-2 infection
title_fullStr N-protein presents early in blood, dried blood and saliva during asymptomatic and symptomatic SARS-CoV-2 infection
title_full_unstemmed N-protein presents early in blood, dried blood and saliva during asymptomatic and symptomatic SARS-CoV-2 infection
title_sort n-protein presents early in blood, dried blood and saliva during asymptomatic and symptomatic sars-cov-2 infection
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/a29c0aa5590d40f2b3a8c214e47a4425
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