Management of chronic hepatitis C virus infection in patients with end-stage renal disease: a review

Jonathan Aguirre Valadez,1 Ignacio García Juárez,1 Rodolfo Rincón Pedrero,2 Aldo Torre11Department of Gastroenterology, 2Department of Nephrology, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Mexico City, Mexico Abstract: Infecti...

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Autores principales:	Aguirre Valadez J, García Juárez I, Rincón Pedrero R, Torre A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/a29c211840f34641bbefcec2713fcb46
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spelling	oai:doaj.org-article:a29c211840f34641bbefcec2713fcb462021-12-02T12:26:56ZManagement of chronic hepatitis C virus infection in patients with end-stage renal disease: a review1178-203Xhttps://doaj.org/article/a29c211840f34641bbefcec2713fcb462015-02-01T00:00:00Zhttp://www.dovepress.com/management-of-chronic-hepatitis-c-virus-infection-in-patients-with-end-peer-reviewed-article-TCRMhttps://doaj.org/toc/1178-203X Jonathan Aguirre Valadez,1 Ignacio García Juárez,1 Rodolfo Rincón Pedrero,2 Aldo Torre11Department of Gastroenterology, 2Department of Nephrology, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Mexico City, Mexico Abstract: Infection with hepatitis C virus (HCV) is highly prevalent in chronic kidney disease (CKD) patients, mainly in those on hemodialysis (HD). The seroprevalence of HCV in developing countries ranges between 7% and 40%. Risk factors for this infection in the CKD population include the number of blood transfusions, duration of end-stage renal disease (ESRD), and prevalence of HCV in HD. Chronic HCV infection in patients with ESRD is associated with an increase in morbidity and mortality in the pre and post kidney transplant periods. The increase in mortality is directly associated with liver complications and an elevated cardiovascular risk in HCV-infected patients on hemodialysis. Antiviral treatment may improve the prognosis of patients with HCV, and standard interferon remains the cornerstone of treatment. Treatment of HCV in patients with CKD is complex, but achieving a sustained viral response may decrease the frequency of complications after transplantation. It appears that HCV-infected patients who remain on maintenance dialysis are at increased risk of death compared with HCV patients undergoing renal transplantation.Keywords: hepatitis C virus, chronic kidney disease, hemodialysis, interferonAguirre Valadez JGarcía Juárez IRincón Pedrero RTorre ADove Medical PressarticleTherapeutics. PharmacologyRM1-950ENTherapeutics and Clinical Risk Management, Vol 2015, Iss default, Pp 329-338 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Therapeutics. Pharmacology RM1-950
spellingShingle	Therapeutics. Pharmacology RM1-950 Aguirre Valadez J García Juárez I Rincón Pedrero R Torre A Management of chronic hepatitis C virus infection in patients with end-stage renal disease: a review
description	Jonathan Aguirre Valadez,1 Ignacio García Juárez,1 Rodolfo Rincón Pedrero,2 Aldo Torre11Department of Gastroenterology, 2Department of Nephrology, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Mexico City, Mexico Abstract: Infection with hepatitis C virus (HCV) is highly prevalent in chronic kidney disease (CKD) patients, mainly in those on hemodialysis (HD). The seroprevalence of HCV in developing countries ranges between 7% and 40%. Risk factors for this infection in the CKD population include the number of blood transfusions, duration of end-stage renal disease (ESRD), and prevalence of HCV in HD. Chronic HCV infection in patients with ESRD is associated with an increase in morbidity and mortality in the pre and post kidney transplant periods. The increase in mortality is directly associated with liver complications and an elevated cardiovascular risk in HCV-infected patients on hemodialysis. Antiviral treatment may improve the prognosis of patients with HCV, and standard interferon remains the cornerstone of treatment. Treatment of HCV in patients with CKD is complex, but achieving a sustained viral response may decrease the frequency of complications after transplantation. It appears that HCV-infected patients who remain on maintenance dialysis are at increased risk of death compared with HCV patients undergoing renal transplantation.Keywords: hepatitis C virus, chronic kidney disease, hemodialysis, interferon
format	article
author	Aguirre Valadez J García Juárez I Rincón Pedrero R Torre A
author_facet	Aguirre Valadez J García Juárez I Rincón Pedrero R Torre A
author_sort	Aguirre Valadez J
title	Management of chronic hepatitis C virus infection in patients with end-stage renal disease: a review
title_short	Management of chronic hepatitis C virus infection in patients with end-stage renal disease: a review
title_full	Management of chronic hepatitis C virus infection in patients with end-stage renal disease: a review
title_fullStr	Management of chronic hepatitis C virus infection in patients with end-stage renal disease: a review
title_full_unstemmed	Management of chronic hepatitis C virus infection in patients with end-stage renal disease: a review
title_sort	management of chronic hepatitis c virus infection in patients with end-stage renal disease: a review
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/a29c211840f34641bbefcec2713fcb46
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Management of chronic hepatitis C virus infection in patients with end-stage renal disease: a review

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