B cell zone reticular cell microenvironments shape CXCL13 gradient formation

Morphogens such as chemokines form gradients to direct graded responses and modulate cell behaviors. Here the authors show, using imaging and computer simulation, that the chemokine CXCL13 originated from follicular reticular cells in the lymph nodes forms both soluble and immobilized gradients to r...

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Autores principales:	Jason Cosgrove, Mario Novkovic, Stefan Albrecht, Natalia B. Pikor, Zhaoukun Zhou, Lucas Onder, Urs Mörbe, Jovana Cupovic, Helen Miller, Kieran Alden, Anne Thuery, Peter O’Toole, Rita Pinter, Simon Jarrett, Emily Taylor, Daniel Venetz, Manfred Heller, Mariagrazia Uguccioni, Daniel F. Legler, Charles J. Lacey, Andrew Coatesworth, Wojciech G. Polak, Tom Cupedo, Bénedicte Manoury, Marcus Thelen, Jens V. Stein, Marlene Wolf, Mark C. Leake, Jon Timmis, Burkhard Ludewig, Mark C. Coles
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a29fe9ea7a8d465093c19a3301a148f3
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spelling	oai:doaj.org-article:a29fe9ea7a8d465093c19a3301a148f32021-12-02T16:17:57ZB cell zone reticular cell microenvironments shape CXCL13 gradient formation10.1038/s41467-020-17135-22041-1723https://doaj.org/article/a29fe9ea7a8d465093c19a3301a148f32020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17135-2https://doaj.org/toc/2041-1723Morphogens such as chemokines form gradients to direct graded responses and modulate cell behaviors. Here the authors show, using imaging and computer simulation, that the chemokine CXCL13 originated from follicular reticular cells in the lymph nodes forms both soluble and immobilized gradients to regulate B cell recruitment and migration.Jason CosgroveMario NovkovicStefan AlbrechtNatalia B. PikorZhaoukun ZhouLucas OnderUrs MörbeJovana CupovicHelen MillerKieran AldenAnne ThueryPeter O’TooleRita PinterSimon JarrettEmily TaylorDaniel VenetzManfred HellerMariagrazia UguccioniDaniel F. LeglerCharles J. LaceyAndrew CoatesworthWojciech G. PolakTom CupedoBénedicte ManouryMarcus ThelenJens V. SteinMarlene WolfMark C. LeakeJon TimmisBurkhard LudewigMark C. ColesNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jason Cosgrove Mario Novkovic Stefan Albrecht Natalia B. Pikor Zhaoukun Zhou Lucas Onder Urs Mörbe Jovana Cupovic Helen Miller Kieran Alden Anne Thuery Peter O’Toole Rita Pinter Simon Jarrett Emily Taylor Daniel Venetz Manfred Heller Mariagrazia Uguccioni Daniel F. Legler Charles J. Lacey Andrew Coatesworth Wojciech G. Polak Tom Cupedo Bénedicte Manoury Marcus Thelen Jens V. Stein Marlene Wolf Mark C. Leake Jon Timmis Burkhard Ludewig Mark C. Coles B cell zone reticular cell microenvironments shape CXCL13 gradient formation
description	Morphogens such as chemokines form gradients to direct graded responses and modulate cell behaviors. Here the authors show, using imaging and computer simulation, that the chemokine CXCL13 originated from follicular reticular cells in the lymph nodes forms both soluble and immobilized gradients to regulate B cell recruitment and migration.
format	article
author	Jason Cosgrove Mario Novkovic Stefan Albrecht Natalia B. Pikor Zhaoukun Zhou Lucas Onder Urs Mörbe Jovana Cupovic Helen Miller Kieran Alden Anne Thuery Peter O’Toole Rita Pinter Simon Jarrett Emily Taylor Daniel Venetz Manfred Heller Mariagrazia Uguccioni Daniel F. Legler Charles J. Lacey Andrew Coatesworth Wojciech G. Polak Tom Cupedo Bénedicte Manoury Marcus Thelen Jens V. Stein Marlene Wolf Mark C. Leake Jon Timmis Burkhard Ludewig Mark C. Coles
author_facet	Jason Cosgrove Mario Novkovic Stefan Albrecht Natalia B. Pikor Zhaoukun Zhou Lucas Onder Urs Mörbe Jovana Cupovic Helen Miller Kieran Alden Anne Thuery Peter O’Toole Rita Pinter Simon Jarrett Emily Taylor Daniel Venetz Manfred Heller Mariagrazia Uguccioni Daniel F. Legler Charles J. Lacey Andrew Coatesworth Wojciech G. Polak Tom Cupedo Bénedicte Manoury Marcus Thelen Jens V. Stein Marlene Wolf Mark C. Leake Jon Timmis Burkhard Ludewig Mark C. Coles
author_sort	Jason Cosgrove
title	B cell zone reticular cell microenvironments shape CXCL13 gradient formation
title_short	B cell zone reticular cell microenvironments shape CXCL13 gradient formation
title_full	B cell zone reticular cell microenvironments shape CXCL13 gradient formation
title_fullStr	B cell zone reticular cell microenvironments shape CXCL13 gradient formation
title_full_unstemmed	B cell zone reticular cell microenvironments shape CXCL13 gradient formation
title_sort	b cell zone reticular cell microenvironments shape cxcl13 gradient formation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a29fe9ea7a8d465093c19a3301a148f3
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B cell zone reticular cell microenvironments shape CXCL13 gradient formation

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