Ternary complex of Kif2A-bound tandem tubulin heterodimers represents a kinesin-13-mediated microtubule depolymerization reaction intermediate

The kinesin-13 family of microtubule (MT) depolymerases are major regulators of MT dynamics. Here the authors provide insights into the MT depolymerization mechanism by solving the crystal structure of a kinesin-13 monomer (Kif2A) in complex with two bent αβ-tubulin heterodimers.

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Autores principales:	Daria Trofimova, Mohammadjavad Paydar, Anthony Zara, Lama Talje, Benjamin H. Kwok, John S. Allingham
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a2a096fb354d4845bcb10edf40492f47
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spelling	oai:doaj.org-article:a2a096fb354d4845bcb10edf40492f472021-12-02T16:49:54ZTernary complex of Kif2A-bound tandem tubulin heterodimers represents a kinesin-13-mediated microtubule depolymerization reaction intermediate10.1038/s41467-018-05025-72041-1723https://doaj.org/article/a2a096fb354d4845bcb10edf40492f472018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05025-7https://doaj.org/toc/2041-1723The kinesin-13 family of microtubule (MT) depolymerases are major regulators of MT dynamics. Here the authors provide insights into the MT depolymerization mechanism by solving the crystal structure of a kinesin-13 monomer (Kif2A) in complex with two bent αβ-tubulin heterodimers.Daria TrofimovaMohammadjavad PaydarAnthony ZaraLama TaljeBenjamin H. KwokJohn S. AllinghamNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daria Trofimova Mohammadjavad Paydar Anthony Zara Lama Talje Benjamin H. Kwok John S. Allingham Ternary complex of Kif2A-bound tandem tubulin heterodimers represents a kinesin-13-mediated microtubule depolymerization reaction intermediate
description	The kinesin-13 family of microtubule (MT) depolymerases are major regulators of MT dynamics. Here the authors provide insights into the MT depolymerization mechanism by solving the crystal structure of a kinesin-13 monomer (Kif2A) in complex with two bent αβ-tubulin heterodimers.
format	article
author	Daria Trofimova Mohammadjavad Paydar Anthony Zara Lama Talje Benjamin H. Kwok John S. Allingham
author_facet	Daria Trofimova Mohammadjavad Paydar Anthony Zara Lama Talje Benjamin H. Kwok John S. Allingham
author_sort	Daria Trofimova
title	Ternary complex of Kif2A-bound tandem tubulin heterodimers represents a kinesin-13-mediated microtubule depolymerization reaction intermediate
title_short	Ternary complex of Kif2A-bound tandem tubulin heterodimers represents a kinesin-13-mediated microtubule depolymerization reaction intermediate
title_full	Ternary complex of Kif2A-bound tandem tubulin heterodimers represents a kinesin-13-mediated microtubule depolymerization reaction intermediate
title_fullStr	Ternary complex of Kif2A-bound tandem tubulin heterodimers represents a kinesin-13-mediated microtubule depolymerization reaction intermediate
title_full_unstemmed	Ternary complex of Kif2A-bound tandem tubulin heterodimers represents a kinesin-13-mediated microtubule depolymerization reaction intermediate
title_sort	ternary complex of kif2a-bound tandem tubulin heterodimers represents a kinesin-13-mediated microtubule depolymerization reaction intermediate
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a2a096fb354d4845bcb10edf40492f47
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Ternary complex of Kif2A-bound tandem tubulin heterodimers represents a kinesin-13-mediated microtubule depolymerization reaction intermediate

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