Prognostic value of heart rate variability in patients with coronary artery disease in the current treatment era.

Coronary artery disease (CAD) mortality has declined substantially over the past decades thanks to advancing medical and interventional/surgical treatments; therefore, the prognostic value of the heart rate variability in CAD in the current treatment era is not well established. We evaluated the pro...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Antti O Vuoti, Mikko P Tulppo, Olavi H Ukkola, M Juhani Junttila, Heikki V Huikuri, Antti M Kiviniemi, Juha S Perkiömäki
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a2a1e0015ec44786843517279f3bfd9b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a2a1e0015ec44786843517279f3bfd9b
record_format	dspace
spelling	oai:doaj.org-article:a2a1e0015ec44786843517279f3bfd9b2021-12-02T20:09:40ZPrognostic value of heart rate variability in patients with coronary artery disease in the current treatment era.1932-620310.1371/journal.pone.0254107https://doaj.org/article/a2a1e0015ec44786843517279f3bfd9b2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254107https://doaj.org/toc/1932-6203Coronary artery disease (CAD) mortality has declined substantially over the past decades thanks to advancing medical and interventional/surgical treatments; therefore, the prognostic value of the heart rate variability in CAD in the current treatment era is not well established. We evaluated the prognostic significance of baseline heart rate variability in 1,757 ARTEMIS study patients with angiographically verified CAD. During an average follow-up time of 8.7 ± 2.2 years, a total of 285 (16.2%) patients died. Of the patients, 63 (3.6%) suffered sudden cardiac death or were resuscitated from sudden cardiac arrest (SCD/SCA), 60 (3.4%) experienced non-sudden cardiac death (NSCD), and death attributable to non-cardiac causes (NCD) occurred in 162 (9.2%) patients. For every 10 ms decrease in standard deviation of normal to normal intervals the risk for SCD/SCA, NSCD and NCD increased significantly: HR 1.153 (95% CI 1.075-1.236, p<0.001), HR 1.187 (95% CI 1.102-1.278, p<0.001) and HR 1.080 (95% CI 1.037-1.125, p<0.001), respectively. The natural logarithm of the low-frequency component of the power spectrum and the short-term scaling exponent of the detrended fluctuation analysis also had significant association with all modes of death (p<0.001). After relevant adjustment, standard deviation of normal-to-normal intervals retained its association with NSCD and NCD (p<0.01), the natural logarithm of the low-frequency component of the power spectrum with all modes of death (p from <0.05 to <0.01), and the short-term scaling exponent of the detrended fluctuation analysis with SCD/SCA (p<0.05) and NCD (p<0.001). In conclusion, impairment of many measures of heart rate variability predicts mortality but is not associated with any specific mode of death in patients with stable CAD during the current treatment era, limiting the clinical applicability of heart rate variability to targeting therapy.Antti O VuotiMikko P TulppoOlavi H UkkolaM Juhani JunttilaHeikki V HuikuriAntti M KiviniemiJuha S PerkiömäkiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254107 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Antti O Vuoti Mikko P Tulppo Olavi H Ukkola M Juhani Junttila Heikki V Huikuri Antti M Kiviniemi Juha S Perkiömäki Prognostic value of heart rate variability in patients with coronary artery disease in the current treatment era.
description	Coronary artery disease (CAD) mortality has declined substantially over the past decades thanks to advancing medical and interventional/surgical treatments; therefore, the prognostic value of the heart rate variability in CAD in the current treatment era is not well established. We evaluated the prognostic significance of baseline heart rate variability in 1,757 ARTEMIS study patients with angiographically verified CAD. During an average follow-up time of 8.7 ± 2.2 years, a total of 285 (16.2%) patients died. Of the patients, 63 (3.6%) suffered sudden cardiac death or were resuscitated from sudden cardiac arrest (SCD/SCA), 60 (3.4%) experienced non-sudden cardiac death (NSCD), and death attributable to non-cardiac causes (NCD) occurred in 162 (9.2%) patients. For every 10 ms decrease in standard deviation of normal to normal intervals the risk for SCD/SCA, NSCD and NCD increased significantly: HR 1.153 (95% CI 1.075-1.236, p<0.001), HR 1.187 (95% CI 1.102-1.278, p<0.001) and HR 1.080 (95% CI 1.037-1.125, p<0.001), respectively. The natural logarithm of the low-frequency component of the power spectrum and the short-term scaling exponent of the detrended fluctuation analysis also had significant association with all modes of death (p<0.001). After relevant adjustment, standard deviation of normal-to-normal intervals retained its association with NSCD and NCD (p<0.01), the natural logarithm of the low-frequency component of the power spectrum with all modes of death (p from <0.05 to <0.01), and the short-term scaling exponent of the detrended fluctuation analysis with SCD/SCA (p<0.05) and NCD (p<0.001). In conclusion, impairment of many measures of heart rate variability predicts mortality but is not associated with any specific mode of death in patients with stable CAD during the current treatment era, limiting the clinical applicability of heart rate variability to targeting therapy.
format	article
author	Antti O Vuoti Mikko P Tulppo Olavi H Ukkola M Juhani Junttila Heikki V Huikuri Antti M Kiviniemi Juha S Perkiömäki
author_facet	Antti O Vuoti Mikko P Tulppo Olavi H Ukkola M Juhani Junttila Heikki V Huikuri Antti M Kiviniemi Juha S Perkiömäki
author_sort	Antti O Vuoti
title	Prognostic value of heart rate variability in patients with coronary artery disease in the current treatment era.
title_short	Prognostic value of heart rate variability in patients with coronary artery disease in the current treatment era.
title_full	Prognostic value of heart rate variability in patients with coronary artery disease in the current treatment era.
title_fullStr	Prognostic value of heart rate variability in patients with coronary artery disease in the current treatment era.
title_full_unstemmed	Prognostic value of heart rate variability in patients with coronary artery disease in the current treatment era.
title_sort	prognostic value of heart rate variability in patients with coronary artery disease in the current treatment era.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/a2a1e0015ec44786843517279f3bfd9b
work_keys_str_mv	AT anttiovuoti prognosticvalueofheartratevariabilityinpatientswithcoronaryarterydiseaseinthecurrenttreatmentera AT mikkoptulppo prognosticvalueofheartratevariabilityinpatientswithcoronaryarterydiseaseinthecurrenttreatmentera AT olavihukkola prognosticvalueofheartratevariabilityinpatientswithcoronaryarterydiseaseinthecurrenttreatmentera AT mjuhanijunttila prognosticvalueofheartratevariabilityinpatientswithcoronaryarterydiseaseinthecurrenttreatmentera AT heikkivhuikuri prognosticvalueofheartratevariabilityinpatientswithcoronaryarterydiseaseinthecurrenttreatmentera AT anttimkiviniemi prognosticvalueofheartratevariabilityinpatientswithcoronaryarterydiseaseinthecurrenttreatmentera AT juhasperkiomaki prognosticvalueofheartratevariabilityinpatientswithcoronaryarterydiseaseinthecurrenttreatmentera
_version_	1718375082203545600

Prognostic value of heart rate variability in patients with coronary artery disease in the current treatment era.

Ejemplares similares