Effects of Donor-Recipient Age Difference in Renal Transplantation, an Investigation on Renal Function and Fluid Proteome

Xinning Wang,1 Qiang Zu,1 Jinshan Lu,1 Lei Zhang,1 Qiang Zhu,1 Xuefeng Sun,2 Jun Dong1 1Department of Urology, Chinese PLA General Hospital, Beijing, People’s Republic of China; 2Department of Nephrology, Chinese PLA General Hospital, Beijing, People’s Republic of ChinaCorrespondence: Xuefeng Sun; J...

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Autores principales:	Wang X, Zu Q, Lu J, Zhang L, Zhu Q, Sun X, Dong J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	renal transplantation aging proteome living donor transplantation Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/a2ac358effa94ab2b4f9052b70550bda
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spelling	oai:doaj.org-article:a2ac358effa94ab2b4f9052b70550bda2021-12-02T14:49:53ZEffects of Donor-Recipient Age Difference in Renal Transplantation, an Investigation on Renal Function and Fluid Proteome1178-1998https://doaj.org/article/a2ac358effa94ab2b4f9052b70550bda2021-07-01T00:00:00Zhttps://www.dovepress.com/effects-of-donor-recipient-age-difference-in-renal-transplantation-an--peer-reviewed-fulltext-article-CIAhttps://doaj.org/toc/1178-1998Xinning Wang,1 Qiang Zu,1 Jinshan Lu,1 Lei Zhang,1 Qiang Zhu,1 Xuefeng Sun,2 Jun Dong1 1Department of Urology, Chinese PLA General Hospital, Beijing, People’s Republic of China; 2Department of Nephrology, Chinese PLA General Hospital, Beijing, People’s Republic of ChinaCorrespondence: Xuefeng Sun; Jun Dong Email xfssun@126.com; jundong@vip.126.comIntroduction: Our previous study revealed that a young internal environment ameliorated kidney aging by virtue of an animal model of heterochronic parabiosis and a model of heterochronic renal transplantation. In this research, we used proteome to investigate the effects of donor-recipient age difference in clinical renal transplantation.Methods: This study included 10 pairs of renal transplantation donors and recipients with an age difference of greater than 20 years to their corresponding recipients/donors. All recipients have received transplantation more than 3 years ago. Renal function and the serum/urine proteomes of the donors and recipients were analyzed.Results: The renal function was similar between the young recipients and the old donors. In contrast, the renal function of the young donors was significantly superior to that of the old recipients. Furthermore, 497 and 975 proteins were identified in the serum and urine proteomes, respectively. The content of SLC3A2 in the blood was found to be related to aging, while the contents of SERPINA1 and SERPINA3 in the urine were related to immune functions after renal transplantation.Conclusion: This study demonstrated that, in the human body, a younger internal environment could ameliorate kidney aging and provided not only clinical evidence for increasing the age limit of kidney transplant donors but also new information for kidney aging research.Keywords: renal transplantation, aging, proteome, living donor transplantationWang XZu QLu JZhang LZhu QSun XDong JDove Medical Pressarticlerenal transplantationagingproteomeliving donor transplantationGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 16, Pp 1457-1470 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	renal transplantation aging proteome living donor transplantation Geriatrics RC952-954.6
spellingShingle	renal transplantation aging proteome living donor transplantation Geriatrics RC952-954.6 Wang X Zu Q Lu J Zhang L Zhu Q Sun X Dong J Effects of Donor-Recipient Age Difference in Renal Transplantation, an Investigation on Renal Function and Fluid Proteome
description	Xinning Wang,1 Qiang Zu,1 Jinshan Lu,1 Lei Zhang,1 Qiang Zhu,1 Xuefeng Sun,2 Jun Dong1 1Department of Urology, Chinese PLA General Hospital, Beijing, People’s Republic of China; 2Department of Nephrology, Chinese PLA General Hospital, Beijing, People’s Republic of ChinaCorrespondence: Xuefeng Sun; Jun Dong Email xfssun@126.com; jundong@vip.126.comIntroduction: Our previous study revealed that a young internal environment ameliorated kidney aging by virtue of an animal model of heterochronic parabiosis and a model of heterochronic renal transplantation. In this research, we used proteome to investigate the effects of donor-recipient age difference in clinical renal transplantation.Methods: This study included 10 pairs of renal transplantation donors and recipients with an age difference of greater than 20 years to their corresponding recipients/donors. All recipients have received transplantation more than 3 years ago. Renal function and the serum/urine proteomes of the donors and recipients were analyzed.Results: The renal function was similar between the young recipients and the old donors. In contrast, the renal function of the young donors was significantly superior to that of the old recipients. Furthermore, 497 and 975 proteins were identified in the serum and urine proteomes, respectively. The content of SLC3A2 in the blood was found to be related to aging, while the contents of SERPINA1 and SERPINA3 in the urine were related to immune functions after renal transplantation.Conclusion: This study demonstrated that, in the human body, a younger internal environment could ameliorate kidney aging and provided not only clinical evidence for increasing the age limit of kidney transplant donors but also new information for kidney aging research.Keywords: renal transplantation, aging, proteome, living donor transplantation
format	article
author	Wang X Zu Q Lu J Zhang L Zhu Q Sun X Dong J
author_facet	Wang X Zu Q Lu J Zhang L Zhu Q Sun X Dong J
author_sort	Wang X
title	Effects of Donor-Recipient Age Difference in Renal Transplantation, an Investigation on Renal Function and Fluid Proteome
title_short	Effects of Donor-Recipient Age Difference in Renal Transplantation, an Investigation on Renal Function and Fluid Proteome
title_full	Effects of Donor-Recipient Age Difference in Renal Transplantation, an Investigation on Renal Function and Fluid Proteome
title_fullStr	Effects of Donor-Recipient Age Difference in Renal Transplantation, an Investigation on Renal Function and Fluid Proteome
title_full_unstemmed	Effects of Donor-Recipient Age Difference in Renal Transplantation, an Investigation on Renal Function and Fluid Proteome
title_sort	effects of donor-recipient age difference in renal transplantation, an investigation on renal function and fluid proteome
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/a2ac358effa94ab2b4f9052b70550bda
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Effects of Donor-Recipient Age Difference in Renal Transplantation, an Investigation on Renal Function and Fluid Proteome

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