Potential drug-drug interactions of antiretrovirals and antimicrobials detected by three databases

Abstract Standard treatment for HIV infection involves a combination of antiretrovirals. Additionally, opportunistic infections in HIV infected patients require further antimicrobial medications that might cause drug-drug interactions (DDIs). The objective of this study was to to compare the recogni...

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Autores principales:	Pornpun Vivithanaporn, Teetat Kongratanapasert, Bovornpat Suriyapakorn, Pichayut Songkunlertchai, Patpicha Mongkonariyawong, Patanachai K. Limpikirati, Phisit Khemawoot
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a2adadc42fbc42dcacfe18b90d18f5b4
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spelling	oai:doaj.org-article:a2adadc42fbc42dcacfe18b90d18f5b42021-12-02T17:05:45ZPotential drug-drug interactions of antiretrovirals and antimicrobials detected by three databases10.1038/s41598-021-85586-82045-2322https://doaj.org/article/a2adadc42fbc42dcacfe18b90d18f5b42021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85586-8https://doaj.org/toc/2045-2322Abstract Standard treatment for HIV infection involves a combination of antiretrovirals. Additionally, opportunistic infections in HIV infected patients require further antimicrobial medications that might cause drug-drug interactions (DDIs). The objective of this study was to to compare the recognition of DDIs between antiretrovirals and antimicrobials by three proprietary databases and evaluate their concordance. 114 items of antiretrovirals and antimicrobials from the National List of Essential Medicines of Thailand 2018 were used in the study. However, 21 items were not recognised by Micromedex, Drugs.com, and Liverpool HIV interactions. Only 93 items were available for the detection of potential DDIs by the three databases. Potential DDIs detected from the three databases included 292 pairs. Liverpool showed the highest number of DDIs with 285 pairs compared with 259 pairs by drugs.com and 133 pairs by Micromedex. Regarding the severity classifications, Liverpool reported 10% Contraindicated; Micromedex reported 14% contraindicated and 59% major; Drugs.com reported 21% major. The Fleiss’ kappa agreements were fair to poor among the three databases, higher agreement was observed for DDIs classified as severe. This study highlights the need to harmonize the evaluation and interpretation of DDI risk in order to produce standardized information to support prescribers.Pornpun VivithanapornTeetat KongratanapasertBovornpat SuriyapakornPichayut SongkunlertchaiPatpicha MongkonariyawongPatanachai K. LimpikiratiPhisit KhemawootNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pornpun Vivithanaporn Teetat Kongratanapasert Bovornpat Suriyapakorn Pichayut Songkunlertchai Patpicha Mongkonariyawong Patanachai K. Limpikirati Phisit Khemawoot Potential drug-drug interactions of antiretrovirals and antimicrobials detected by three databases
description	Abstract Standard treatment for HIV infection involves a combination of antiretrovirals. Additionally, opportunistic infections in HIV infected patients require further antimicrobial medications that might cause drug-drug interactions (DDIs). The objective of this study was to to compare the recognition of DDIs between antiretrovirals and antimicrobials by three proprietary databases and evaluate their concordance. 114 items of antiretrovirals and antimicrobials from the National List of Essential Medicines of Thailand 2018 were used in the study. However, 21 items were not recognised by Micromedex, Drugs.com, and Liverpool HIV interactions. Only 93 items were available for the detection of potential DDIs by the three databases. Potential DDIs detected from the three databases included 292 pairs. Liverpool showed the highest number of DDIs with 285 pairs compared with 259 pairs by drugs.com and 133 pairs by Micromedex. Regarding the severity classifications, Liverpool reported 10% Contraindicated; Micromedex reported 14% contraindicated and 59% major; Drugs.com reported 21% major. The Fleiss’ kappa agreements were fair to poor among the three databases, higher agreement was observed for DDIs classified as severe. This study highlights the need to harmonize the evaluation and interpretation of DDI risk in order to produce standardized information to support prescribers.
format	article
author	Pornpun Vivithanaporn Teetat Kongratanapasert Bovornpat Suriyapakorn Pichayut Songkunlertchai Patpicha Mongkonariyawong Patanachai K. Limpikirati Phisit Khemawoot
author_facet	Pornpun Vivithanaporn Teetat Kongratanapasert Bovornpat Suriyapakorn Pichayut Songkunlertchai Patpicha Mongkonariyawong Patanachai K. Limpikirati Phisit Khemawoot
author_sort	Pornpun Vivithanaporn
title	Potential drug-drug interactions of antiretrovirals and antimicrobials detected by three databases
title_short	Potential drug-drug interactions of antiretrovirals and antimicrobials detected by three databases
title_full	Potential drug-drug interactions of antiretrovirals and antimicrobials detected by three databases
title_fullStr	Potential drug-drug interactions of antiretrovirals and antimicrobials detected by three databases
title_full_unstemmed	Potential drug-drug interactions of antiretrovirals and antimicrobials detected by three databases
title_sort	potential drug-drug interactions of antiretrovirals and antimicrobials detected by three databases
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a2adadc42fbc42dcacfe18b90d18f5b4
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Potential drug-drug interactions of antiretrovirals and antimicrobials detected by three databases

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