Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy

Fukutin-related protein (FKRP) catalyses the addition of ribitol-phosphate (RboP) to the O-mannosyl glycan of α-dystroglycan and mutations in FKRP cause dystroglycanopathy. Here the authors provide insights into its oligomerization and recognition of the substrates, CDP-Rbo and the RboP-(phospho-)co...

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Autores principales:	Naoyuki Kuwabara, Rieko Imae, Hiroshi Manya, Tomohiro Tanaka, Mamoru Mizuno, Hiroki Tsumoto, Motoi Kanagawa, Kazuhiro Kobayashi, Tatsushi Toda, Toshiya Senda, Tamao Endo, Ryuichi Kato
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a2adec609bc8456584e53ec9bdfe4352
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spelling	oai:doaj.org-article:a2adec609bc8456584e53ec9bdfe43522021-12-02T14:41:01ZCrystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy10.1038/s41467-019-14220-z2041-1723https://doaj.org/article/a2adec609bc8456584e53ec9bdfe43522020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14220-zhttps://doaj.org/toc/2041-1723Fukutin-related protein (FKRP) catalyses the addition of ribitol-phosphate (RboP) to the O-mannosyl glycan of α-dystroglycan and mutations in FKRP cause dystroglycanopathy. Here the authors provide insights into its oligomerization and recognition of the substrates, CDP-Rbo and the RboP-(phospho-)core M3 glycan, by determining the crystal structures of human FKRP.Naoyuki KuwabaraRieko ImaeHiroshi ManyaTomohiro TanakaMamoru MizunoHiroki TsumotoMotoi KanagawaKazuhiro KobayashiTatsushi TodaToshiya SendaTamao EndoRyuichi KatoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Naoyuki Kuwabara Rieko Imae Hiroshi Manya Tomohiro Tanaka Mamoru Mizuno Hiroki Tsumoto Motoi Kanagawa Kazuhiro Kobayashi Tatsushi Toda Toshiya Senda Tamao Endo Ryuichi Kato Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy
description	Fukutin-related protein (FKRP) catalyses the addition of ribitol-phosphate (RboP) to the O-mannosyl glycan of α-dystroglycan and mutations in FKRP cause dystroglycanopathy. Here the authors provide insights into its oligomerization and recognition of the substrates, CDP-Rbo and the RboP-(phospho-)core M3 glycan, by determining the crystal structures of human FKRP.
format	article
author	Naoyuki Kuwabara Rieko Imae Hiroshi Manya Tomohiro Tanaka Mamoru Mizuno Hiroki Tsumoto Motoi Kanagawa Kazuhiro Kobayashi Tatsushi Toda Toshiya Senda Tamao Endo Ryuichi Kato
author_facet	Naoyuki Kuwabara Rieko Imae Hiroshi Manya Tomohiro Tanaka Mamoru Mizuno Hiroki Tsumoto Motoi Kanagawa Kazuhiro Kobayashi Tatsushi Toda Toshiya Senda Tamao Endo Ryuichi Kato
author_sort	Naoyuki Kuwabara
title	Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy
title_short	Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy
title_full	Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy
title_fullStr	Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy
title_full_unstemmed	Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy
title_sort	crystal structures of fukutin-related protein (fkrp), a ribitol-phosphate transferase related to muscular dystrophy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a2adec609bc8456584e53ec9bdfe4352
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Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy

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