Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion

Blocking PD-1 function on T cells is thought to be a viable strategy to prevent virus-induced or tumor-induced T cell exhaustion. Here the authors link the zinc-finger transcription factor SALL4 with miR-200c inhibition of PD-L1 expression by hepatocytes in patients with HBV-induced hepatocellular c...

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Autores principales:	Cheng Sun, Peixiang Lan, Qiuju Han, Mei Huang, Zhihong Zhang, Geliang Xu, Jiaxi Song, Jinyu Wang, Haiming Wei, Jian Zhang, Rui Sun, Cai Zhang, Zhigang Tian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a2adf458c75e4941931a4d808f8828de
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spelling	oai:doaj.org-article:a2adf458c75e4941931a4d808f8828de2021-12-02T17:31:42ZOncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion10.1038/s41467-018-03584-32041-1723https://doaj.org/article/a2adf458c75e4941931a4d808f8828de2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03584-3https://doaj.org/toc/2041-1723Blocking PD-1 function on T cells is thought to be a viable strategy to prevent virus-induced or tumor-induced T cell exhaustion. Here the authors link the zinc-finger transcription factor SALL4 with miR-200c inhibition of PD-L1 expression by hepatocytes in patients with HBV-induced hepatocellular carcinoma.Cheng SunPeixiang LanQiuju HanMei HuangZhihong ZhangGeliang XuJiaxi SongJinyu WangHaiming WeiJian ZhangRui SunCai ZhangZhigang TianNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cheng Sun Peixiang Lan Qiuju Han Mei Huang Zhihong Zhang Geliang Xu Jiaxi Song Jinyu Wang Haiming Wei Jian Zhang Rui Sun Cai Zhang Zhigang Tian Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion
description	Blocking PD-1 function on T cells is thought to be a viable strategy to prevent virus-induced or tumor-induced T cell exhaustion. Here the authors link the zinc-finger transcription factor SALL4 with miR-200c inhibition of PD-L1 expression by hepatocytes in patients with HBV-induced hepatocellular carcinoma.
format	article
author	Cheng Sun Peixiang Lan Qiuju Han Mei Huang Zhihong Zhang Geliang Xu Jiaxi Song Jinyu Wang Haiming Wei Jian Zhang Rui Sun Cai Zhang Zhigang Tian
author_facet	Cheng Sun Peixiang Lan Qiuju Han Mei Huang Zhihong Zhang Geliang Xu Jiaxi Song Jinyu Wang Haiming Wei Jian Zhang Rui Sun Cai Zhang Zhigang Tian
author_sort	Cheng Sun
title	Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion
title_short	Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion
title_full	Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion
title_fullStr	Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion
title_full_unstemmed	Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion
title_sort	oncofetal gene sall4 reactivation by hepatitis b virus counteracts mir-200c in pd-l1-induced t cell exhaustion
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a2adf458c75e4941931a4d808f8828de
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Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion

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