Identifying mechanisms of Epimedii Folium against Alzheimer’s disease a network pharmacology approach Epimedii Folium treats Alzheimer’s disease PI3K-AKT

To elucidate the mechanism of the multi-target action of Epimedii Folium on Alzheimer’s disease, this study focuses on the analysis of network pharmacology. Based on a bioinformatics approach, this study obtained the effective components of Epimedium through the Traditional Chinese Medicine Systems...

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Autores principales: Yan Zhao, Guangmei Liu, Yang Yang, Ling Chen, Ying Shang, Qian Hong
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Lenguaje:EN
Publicado: SAGE Publishing 2021
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Acceso en línea:https://doaj.org/article/a2aef3f835c44bb8b9cb67a374f3bf14
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spelling oai:doaj.org-article:a2aef3f835c44bb8b9cb67a374f3bf142021-11-19T23:03:58ZIdentifying mechanisms of Epimedii Folium against Alzheimer’s disease a network pharmacology approach Epimedii Folium treats Alzheimer’s disease PI3K-AKT2058-739210.1177/20587392211041435https://doaj.org/article/a2aef3f835c44bb8b9cb67a374f3bf142021-11-01T00:00:00Zhttps://doi.org/10.1177/20587392211041435https://doaj.org/toc/2058-7392To elucidate the mechanism of the multi-target action of Epimedii Folium on Alzheimer’s disease, this study focuses on the analysis of network pharmacology. Based on a bioinformatics approach, this study obtained the effective components of Epimedium through the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform, predicted the compound targets through the Pharmapper and Swiss target prediction database and then through Gene Expression Omnibus Datasets and Therapeutic Target Database. We collected and analysed of heral and disease targets, constructed the network. Through the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, Gene Ontology enrichment, then the key targets and pathways of Epimedii Folium to cope with Alzheimer’s disease have been identified. Twenty-three bioactive components and 477 potential target genes of Epimedii Folium were identified. A total of 1612 target diseases were identified. Through network module analysis, 30 hub target genes were identified. Through enrichment analysis of the KEGG pathway, hub target genes were largely enriched in the PI3K-AKT signaling pathway. Through the analysis of network pharmacology, it was found that Epimedii Folium might play the role of multi-compound and multi-target therapy through the PI3K-AKT signaling pathway. These findings provide helpful directions for future clinical studies.Yan ZhaoGuangmei LiuYang YangLing ChenYing ShangQian HongSAGE PublishingarticleMedicineRENEuropean Journal of Inflammation, Vol 19 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
spellingShingle Medicine
R
Yan Zhao
Guangmei Liu
Yang Yang
Ling Chen
Ying Shang
Qian Hong
Identifying mechanisms of Epimedii Folium against Alzheimer’s disease a network pharmacology approach Epimedii Folium treats Alzheimer’s disease PI3K-AKT
description To elucidate the mechanism of the multi-target action of Epimedii Folium on Alzheimer’s disease, this study focuses on the analysis of network pharmacology. Based on a bioinformatics approach, this study obtained the effective components of Epimedium through the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform, predicted the compound targets through the Pharmapper and Swiss target prediction database and then through Gene Expression Omnibus Datasets and Therapeutic Target Database. We collected and analysed of heral and disease targets, constructed the network. Through the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, Gene Ontology enrichment, then the key targets and pathways of Epimedii Folium to cope with Alzheimer’s disease have been identified. Twenty-three bioactive components and 477 potential target genes of Epimedii Folium were identified. A total of 1612 target diseases were identified. Through network module analysis, 30 hub target genes were identified. Through enrichment analysis of the KEGG pathway, hub target genes were largely enriched in the PI3K-AKT signaling pathway. Through the analysis of network pharmacology, it was found that Epimedii Folium might play the role of multi-compound and multi-target therapy through the PI3K-AKT signaling pathway. These findings provide helpful directions for future clinical studies.
format article
author Yan Zhao
Guangmei Liu
Yang Yang
Ling Chen
Ying Shang
Qian Hong
author_facet Yan Zhao
Guangmei Liu
Yang Yang
Ling Chen
Ying Shang
Qian Hong
author_sort Yan Zhao
title Identifying mechanisms of Epimedii Folium against Alzheimer’s disease a network pharmacology approach Epimedii Folium treats Alzheimer’s disease PI3K-AKT
title_short Identifying mechanisms of Epimedii Folium against Alzheimer’s disease a network pharmacology approach Epimedii Folium treats Alzheimer’s disease PI3K-AKT
title_full Identifying mechanisms of Epimedii Folium against Alzheimer’s disease a network pharmacology approach Epimedii Folium treats Alzheimer’s disease PI3K-AKT
title_fullStr Identifying mechanisms of Epimedii Folium against Alzheimer’s disease a network pharmacology approach Epimedii Folium treats Alzheimer’s disease PI3K-AKT
title_full_unstemmed Identifying mechanisms of Epimedii Folium against Alzheimer’s disease a network pharmacology approach Epimedii Folium treats Alzheimer’s disease PI3K-AKT
title_sort identifying mechanisms of epimedii folium against alzheimer’s disease a network pharmacology approach epimedii folium treats alzheimer’s disease pi3k-akt
publisher SAGE Publishing
publishDate 2021
url https://doaj.org/article/a2aef3f835c44bb8b9cb67a374f3bf14
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