Asymptomatic Meibomian Gland Dysfunction and Cardiovascular Disease Risk Factors in a Middle-Aged Population in Taiwan - A Cross-sectional Analysis

Asymptomatic Meibomian Gland Dysfunction and Cardiovascular Disease Risk Factors in a Middle-Aged Population in Taiwan - A Cross-sectional Analysis

Abstract Managing cardiovascular disease (CVD) risk factors is the key to prevent CVD. This study aimed to prevent CVD by introducing asymptomatic meibomian gland dysfunction (MGD), a condition associated with various CVD risk factors, as an early indicator for CVD in middle-aged population. Partici...

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Autores principales: Alexander Chen, Hung-Ta Chen, Hung-Chi Chen, Yi-Tsun Chen, Yih-Hsiou Hwang, Chi-Chin Sun, Ching-Hsi Hsiao, David Hui-Kang Ma, Wei-Chi Wu, Chi-Chun Lai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
Q
Acceso en línea:https://doaj.org/article/a2b032e8e4784bc291f603ddee60945c
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spelling oai:doaj.org-article:a2b032e8e4784bc291f603ddee60945c2021-12-02T12:30:18ZAsymptomatic Meibomian Gland Dysfunction and Cardiovascular Disease Risk Factors in a Middle-Aged Population in Taiwan - A Cross-sectional Analysis10.1038/s41598-017-05368-z2045-2322https://doaj.org/article/a2b032e8e4784bc291f603ddee60945c2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05368-zhttps://doaj.org/toc/2045-2322Abstract Managing cardiovascular disease (CVD) risk factors is the key to prevent CVD. This study aimed to prevent CVD by introducing asymptomatic meibomian gland dysfunction (MGD), a condition associated with various CVD risk factors, as an early indicator for CVD in middle-aged population. Participants with and without asymptomatic MGD underwent standardized questionnaires, physical examinations, and laboratory investigations. One ophthalmologist completed the identification and grading of MGD by using slit-lamp biomicroscopy examination on the eyelid margins, meibomian gland orifices, and meibomian gland secretions. Standardized techniques were used to measure the CVD risk factor parameters. After adjusted for age and gender, CVD risk factors including elevated uric acid (P = 0.01), total cholesterol (Total-C, P < 0.001), low-density lipoprotein cholesterol (LDL-C, P < 0.001), fasting triglyceride (Fasting TG, P < 0.001), decreased high-density lipoprotein cholesterol (HDL-C, P = 0.04), and presence of hepatic steatosis (P = 0.008) were significantly associated with asymptomatic MGD. Stepwise logistic regression analysis revealed that LDL-C (OR: 1.03, 95% CI: 1.02–1.04) and Fasting TG (OR: 1.01; 95% CI: 1.00–1.01) levels were risk factors for having asymptomatic MGD (P < 0.001). Together, the results suggest that asymptomatic MGD may serve as an indicator for CVD.Alexander ChenHung-Ta ChenHung-Chi ChenYi-Tsun ChenYih-Hsiou HwangChi-Chin SunChing-Hsi HsiaoDavid Hui-Kang MaWei-Chi WuChi-Chun LaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Alexander Chen
Hung-Ta Chen
Hung-Chi Chen
Yi-Tsun Chen
Yih-Hsiou Hwang
Chi-Chin Sun
Ching-Hsi Hsiao
David Hui-Kang Ma
Wei-Chi Wu
Chi-Chun Lai
Asymptomatic Meibomian Gland Dysfunction and Cardiovascular Disease Risk Factors in a Middle-Aged Population in Taiwan - A Cross-sectional Analysis
description Abstract Managing cardiovascular disease (CVD) risk factors is the key to prevent CVD. This study aimed to prevent CVD by introducing asymptomatic meibomian gland dysfunction (MGD), a condition associated with various CVD risk factors, as an early indicator for CVD in middle-aged population. Participants with and without asymptomatic MGD underwent standardized questionnaires, physical examinations, and laboratory investigations. One ophthalmologist completed the identification and grading of MGD by using slit-lamp biomicroscopy examination on the eyelid margins, meibomian gland orifices, and meibomian gland secretions. Standardized techniques were used to measure the CVD risk factor parameters. After adjusted for age and gender, CVD risk factors including elevated uric acid (P = 0.01), total cholesterol (Total-C, P < 0.001), low-density lipoprotein cholesterol (LDL-C, P < 0.001), fasting triglyceride (Fasting TG, P < 0.001), decreased high-density lipoprotein cholesterol (HDL-C, P = 0.04), and presence of hepatic steatosis (P = 0.008) were significantly associated with asymptomatic MGD. Stepwise logistic regression analysis revealed that LDL-C (OR: 1.03, 95% CI: 1.02–1.04) and Fasting TG (OR: 1.01; 95% CI: 1.00–1.01) levels were risk factors for having asymptomatic MGD (P < 0.001). Together, the results suggest that asymptomatic MGD may serve as an indicator for CVD.
format article
author Alexander Chen
Hung-Ta Chen
Hung-Chi Chen
Yi-Tsun Chen
Yih-Hsiou Hwang
Chi-Chin Sun
Ching-Hsi Hsiao
David Hui-Kang Ma
Wei-Chi Wu
Chi-Chun Lai
author_facet Alexander Chen
Hung-Ta Chen
Hung-Chi Chen
Yi-Tsun Chen
Yih-Hsiou Hwang
Chi-Chin Sun
Ching-Hsi Hsiao
David Hui-Kang Ma
Wei-Chi Wu
Chi-Chun Lai
author_sort Alexander Chen
title Asymptomatic Meibomian Gland Dysfunction and Cardiovascular Disease Risk Factors in a Middle-Aged Population in Taiwan - A Cross-sectional Analysis
title_short Asymptomatic Meibomian Gland Dysfunction and Cardiovascular Disease Risk Factors in a Middle-Aged Population in Taiwan - A Cross-sectional Analysis
title_full Asymptomatic Meibomian Gland Dysfunction and Cardiovascular Disease Risk Factors in a Middle-Aged Population in Taiwan - A Cross-sectional Analysis
title_fullStr Asymptomatic Meibomian Gland Dysfunction and Cardiovascular Disease Risk Factors in a Middle-Aged Population in Taiwan - A Cross-sectional Analysis
title_full_unstemmed Asymptomatic Meibomian Gland Dysfunction and Cardiovascular Disease Risk Factors in a Middle-Aged Population in Taiwan - A Cross-sectional Analysis
title_sort asymptomatic meibomian gland dysfunction and cardiovascular disease risk factors in a middle-aged population in taiwan - a cross-sectional analysis
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/a2b032e8e4784bc291f603ddee60945c
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