Nox2-dependent neuroinflammation in an EAE model of multiple sclerosis

Multiple sclerosis (MS) is an inflammatory disease of the CNS, characterized by demyelination, focal inflammatory infiltrates and axonal damage. Oxidative stress has been linked to MS pathology. Previous studies have suggested the involvement of NADPH oxidase 2 (Nox2), an enzyme that catalyzes the r...

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Autores principales:	Ravelli Katherine G., Santos Graziella D., dos Santos Nilton B., Munhoz Carolina D., Azzi-Nogueira Deborah, Campos Ana Carolina, Pagano Rosana L., Britto Luiz R., Hernandes Marina S.
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2019
Materias:	multiple sclerosist nadph oxidaset astrocytest cytokines Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/a2b088942e1c4be8b9a85a30d0e0e87f
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spelling	oai:doaj.org-article:a2b088942e1c4be8b9a85a30d0e0e87f2021-12-05T14:11:04ZNox2-dependent neuroinflammation in an EAE model of multiple sclerosis2081-693610.1515/tnsci-2019-0001https://doaj.org/article/a2b088942e1c4be8b9a85a30d0e0e87f2019-03-01T00:00:00Zhttps://doi.org/10.1515/tnsci-2019-0001https://doaj.org/toc/2081-6936Multiple sclerosis (MS) is an inflammatory disease of the CNS, characterized by demyelination, focal inflammatory infiltrates and axonal damage. Oxidative stress has been linked to MS pathology. Previous studies have suggested the involvement of NADPH oxidase 2 (Nox2), an enzyme that catalyzes the reduction of oxygen to produce reactive oxygen species, in the MS pathogenesis. The mechanisms of Nox2 activation on MS are unknown. The purpose of this study was to investigate the effect of Nox2 deletion on experimental autoimmune encephalomyelitis (EAE) onset and severity, on astrocyte activation as well as on pro-inflammatory and anti-inflammatory cytokine induction in striatum and motor cortex.Ravelli Katherine G.Santos Graziella D.dos Santos Nilton B.Munhoz Carolina D.Azzi-Nogueira DeborahCampos Ana CarolinaPagano Rosana L.Britto Luiz R.Hernandes Marina S.De Gruyterarticlemultiple sclerosistnadph oxidasetastrocytestcytokinesNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Neuroscience, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	multiple sclerosist nadph oxidaset astrocytest cytokines Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	multiple sclerosist nadph oxidaset astrocytest cytokines Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Ravelli Katherine G. Santos Graziella D. dos Santos Nilton B. Munhoz Carolina D. Azzi-Nogueira Deborah Campos Ana Carolina Pagano Rosana L. Britto Luiz R. Hernandes Marina S. Nox2-dependent neuroinflammation in an EAE model of multiple sclerosis
description	Multiple sclerosis (MS) is an inflammatory disease of the CNS, characterized by demyelination, focal inflammatory infiltrates and axonal damage. Oxidative stress has been linked to MS pathology. Previous studies have suggested the involvement of NADPH oxidase 2 (Nox2), an enzyme that catalyzes the reduction of oxygen to produce reactive oxygen species, in the MS pathogenesis. The mechanisms of Nox2 activation on MS are unknown. The purpose of this study was to investigate the effect of Nox2 deletion on experimental autoimmune encephalomyelitis (EAE) onset and severity, on astrocyte activation as well as on pro-inflammatory and anti-inflammatory cytokine induction in striatum and motor cortex.
format	article
author	Ravelli Katherine G. Santos Graziella D. dos Santos Nilton B. Munhoz Carolina D. Azzi-Nogueira Deborah Campos Ana Carolina Pagano Rosana L. Britto Luiz R. Hernandes Marina S.
author_facet	Ravelli Katherine G. Santos Graziella D. dos Santos Nilton B. Munhoz Carolina D. Azzi-Nogueira Deborah Campos Ana Carolina Pagano Rosana L. Britto Luiz R. Hernandes Marina S.
author_sort	Ravelli Katherine G.
title	Nox2-dependent neuroinflammation in an EAE model of multiple sclerosis
title_short	Nox2-dependent neuroinflammation in an EAE model of multiple sclerosis
title_full	Nox2-dependent neuroinflammation in an EAE model of multiple sclerosis
title_fullStr	Nox2-dependent neuroinflammation in an EAE model of multiple sclerosis
title_full_unstemmed	Nox2-dependent neuroinflammation in an EAE model of multiple sclerosis
title_sort	nox2-dependent neuroinflammation in an eae model of multiple sclerosis
publisher	De Gruyter
publishDate	2019
url	https://doaj.org/article/a2b088942e1c4be8b9a85a30d0e0e87f
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Nox2-dependent neuroinflammation in an EAE model of multiple sclerosis

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