Metal Nanoparticles for Photodynamic Therapy: A Potential Treatment for Breast Cancer

Breast cancer (BC) is the most common malignant tumor in women worldwide, which seriously threatens women’s physical and mental health. In recent years, photodynamic therapy (PDT) has shown significant advantages in cancer treatment. PDT involves activating photosensitizers with appropriate waveleng...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Liang Shang, Xinglu Zhou, Jiarui Zhang, Yujie Shi, Lei Zhong
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	breast cancer photodynamic therapy metal nanocarriers synergistic therapies Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/a2b1a785a97a4eae88729e8c395c9893
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a2b1a785a97a4eae88729e8c395c9893
record_format	dspace
spelling	oai:doaj.org-article:a2b1a785a97a4eae88729e8c395c98932021-11-11T18:31:20ZMetal Nanoparticles for Photodynamic Therapy: A Potential Treatment for Breast Cancer10.3390/molecules262165321420-3049https://doaj.org/article/a2b1a785a97a4eae88729e8c395c98932021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6532https://doaj.org/toc/1420-3049Breast cancer (BC) is the most common malignant tumor in women worldwide, which seriously threatens women’s physical and mental health. In recent years, photodynamic therapy (PDT) has shown significant advantages in cancer treatment. PDT involves activating photosensitizers with appropriate wavelengths of light, producing transient levels of reactive oxygen species (ROS). Compared with free photosensitizers, the use of nanoparticles in PDT shows great advantages in terms of solubility, early degradation, and biodistribution, as well as more effective intercellular penetration and targeted cancer cell uptake. Under the current circumstances, researchers have made promising efforts to develop nanocarrier photosensitizers. Reasonably designed photosensitizer (PS) nanoparticles can be achieved through non-covalent (self-aggregation, interfacial deposition, interfacial polymerization or core-shell embedding and physical adsorption) or covalent (chemical immobilization or coupling) processes and accumulate in certain tumors through passive and/or active targeting. These PS loading methods provide chemical and physical stability to the PS payload. Among nanoparticles, metal nanoparticles have the advantages of high stability, adjustable size, optical properties, and easy surface functionalization, making them more biocompatible in biological applications. In this review, we summarize the current development and application status of photodynamic therapy for breast cancer, especially the latest developments in the application of metal nanocarriers in breast cancer PDT, and highlight some of the recent synergistic therapies, hopefully providing an accessible overview of the current knowledge that may act as a basis for new ideas or systematic evaluations of already promising results.Liang ShangXinglu ZhouJiarui ZhangYujie ShiLei ZhongMDPI AGarticlebreast cancerphotodynamic therapymetal nanocarrierssynergistic therapiesOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6532, p 6532 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast cancer photodynamic therapy metal nanocarriers synergistic therapies Organic chemistry QD241-441
spellingShingle	breast cancer photodynamic therapy metal nanocarriers synergistic therapies Organic chemistry QD241-441 Liang Shang Xinglu Zhou Jiarui Zhang Yujie Shi Lei Zhong Metal Nanoparticles for Photodynamic Therapy: A Potential Treatment for Breast Cancer
description	Breast cancer (BC) is the most common malignant tumor in women worldwide, which seriously threatens women’s physical and mental health. In recent years, photodynamic therapy (PDT) has shown significant advantages in cancer treatment. PDT involves activating photosensitizers with appropriate wavelengths of light, producing transient levels of reactive oxygen species (ROS). Compared with free photosensitizers, the use of nanoparticles in PDT shows great advantages in terms of solubility, early degradation, and biodistribution, as well as more effective intercellular penetration and targeted cancer cell uptake. Under the current circumstances, researchers have made promising efforts to develop nanocarrier photosensitizers. Reasonably designed photosensitizer (PS) nanoparticles can be achieved through non-covalent (self-aggregation, interfacial deposition, interfacial polymerization or core-shell embedding and physical adsorption) or covalent (chemical immobilization or coupling) processes and accumulate in certain tumors through passive and/or active targeting. These PS loading methods provide chemical and physical stability to the PS payload. Among nanoparticles, metal nanoparticles have the advantages of high stability, adjustable size, optical properties, and easy surface functionalization, making them more biocompatible in biological applications. In this review, we summarize the current development and application status of photodynamic therapy for breast cancer, especially the latest developments in the application of metal nanocarriers in breast cancer PDT, and highlight some of the recent synergistic therapies, hopefully providing an accessible overview of the current knowledge that may act as a basis for new ideas or systematic evaluations of already promising results.
format	article
author	Liang Shang Xinglu Zhou Jiarui Zhang Yujie Shi Lei Zhong
author_facet	Liang Shang Xinglu Zhou Jiarui Zhang Yujie Shi Lei Zhong
author_sort	Liang Shang
title	Metal Nanoparticles for Photodynamic Therapy: A Potential Treatment for Breast Cancer
title_short	Metal Nanoparticles for Photodynamic Therapy: A Potential Treatment for Breast Cancer
title_full	Metal Nanoparticles for Photodynamic Therapy: A Potential Treatment for Breast Cancer
title_fullStr	Metal Nanoparticles for Photodynamic Therapy: A Potential Treatment for Breast Cancer
title_full_unstemmed	Metal Nanoparticles for Photodynamic Therapy: A Potential Treatment for Breast Cancer
title_sort	metal nanoparticles for photodynamic therapy: a potential treatment for breast cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a2b1a785a97a4eae88729e8c395c9893
work_keys_str_mv	AT liangshang metalnanoparticlesforphotodynamictherapyapotentialtreatmentforbreastcancer AT xingluzhou metalnanoparticlesforphotodynamictherapyapotentialtreatmentforbreastcancer AT jiaruizhang metalnanoparticlesforphotodynamictherapyapotentialtreatmentforbreastcancer AT yujieshi metalnanoparticlesforphotodynamictherapyapotentialtreatmentforbreastcancer AT leizhong metalnanoparticlesforphotodynamictherapyapotentialtreatmentforbreastcancer
_version_	1718431841406418944

Metal Nanoparticles for Photodynamic Therapy: A Potential Treatment for Breast Cancer

Ejemplares similares