Accumulation of Paneth Cells in Early Colorectal Adenomas Is Associated with Beta-Catenin Signaling and Poor Patient Prognosis

Accumulation of Paneth Cells in Early Colorectal Adenomas Is Associated with Beta-Catenin Signaling and Poor Patient Prognosis

Background: Previous studies in mice indicated that Paneth cells and c-Kit-positive goblet cells represent the stem cell niche of the small intestine and colon, respectively, partly by supporting Wnt and Notch activation. Whether these cell populations play a similar role in human intestinal cancer...

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Bibliographic Details
Main Authors: Erika López-Arribillaga, Bing Yan, Teresa Lobo-Jarne, Yolanda Guillén, Silvia Menéndez, Montserrat Andreu, Anna Bigas, Mar Iglesias, Lluís Espinosa
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
colorectal cancer
adenomas
stem cell niche
Paneth cells
Wnt
Notch
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/a2b2abc47bf94a33859ea7afe20bbba6
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https://doaj.org/article/a2b2abc47bf94a33859ea7afe20bbba6

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