Nanoparticles for multimodal in vivo imaging in nanomedicine

Jaehong Key,1–3 James F Leary1–41Weldon School of Biomedical Engineering, 2Birck Nanotechnology Center, 3Bindley Bioscience Center, 4College of Veterinary Medicine, Purdue University, West Lafayette, IN, USAAbstract: While nanoparticles are usually designed for targeted drug del...

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Autores principales:	Key J, Leary JF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a2b6bd2050c549228d171806d934bc49
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spelling	oai:doaj.org-article:a2b6bd2050c549228d171806d934bc492021-12-02T07:11:23ZNanoparticles for multimodal in vivo imaging in nanomedicine1178-2013https://doaj.org/article/a2b6bd2050c549228d171806d934bc492014-01-01T00:00:00Zhttp://www.dovepress.com/nanoparticles-for-multimodal-in-vivo-imaging-in-nanomedicine-a15655https://doaj.org/toc/1178-2013 Jaehong Key,1–3 James F Leary1–41Weldon School of Biomedical Engineering, 2Birck Nanotechnology Center, 3Bindley Bioscience Center, 4College of Veterinary Medicine, Purdue University, West Lafayette, IN, USAAbstract: While nanoparticles are usually designed for targeted drug delivery, they can also simultaneously provide diagnostic information by a variety of in vivo imaging methods. These diagnostic capabilities make use of specific properties of nanoparticle core materials. Near-infrared fluorescent probes provide optical detection of cells targeted by real-time nanoparticle-distribution studies within the organ compartments of live, anesthetized animals. By combining different imaging modalities, we can start with deep-body imaging by magnetic resonance imaging or computed tomography, and by using optical imaging, get down to the resolution required for real-time fluorescence-guided surgery.Keywords: nanomedicine, nanoparticles, multimodal imaging, CT, MRI, NIRF, PET, cancerKey JLeary JFDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 711-726 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Key J Leary JF Nanoparticles for multimodal in vivo imaging in nanomedicine
description	Jaehong Key,1–3 James F Leary1–41Weldon School of Biomedical Engineering, 2Birck Nanotechnology Center, 3Bindley Bioscience Center, 4College of Veterinary Medicine, Purdue University, West Lafayette, IN, USAAbstract: While nanoparticles are usually designed for targeted drug delivery, they can also simultaneously provide diagnostic information by a variety of in vivo imaging methods. These diagnostic capabilities make use of specific properties of nanoparticle core materials. Near-infrared fluorescent probes provide optical detection of cells targeted by real-time nanoparticle-distribution studies within the organ compartments of live, anesthetized animals. By combining different imaging modalities, we can start with deep-body imaging by magnetic resonance imaging or computed tomography, and by using optical imaging, get down to the resolution required for real-time fluorescence-guided surgery.Keywords: nanomedicine, nanoparticles, multimodal imaging, CT, MRI, NIRF, PET, cancer
format	article
author	Key J Leary JF
author_facet	Key J Leary JF
author_sort	Key J
title	Nanoparticles for multimodal in vivo imaging in nanomedicine
title_short	Nanoparticles for multimodal in vivo imaging in nanomedicine
title_full	Nanoparticles for multimodal in vivo imaging in nanomedicine
title_fullStr	Nanoparticles for multimodal in vivo imaging in nanomedicine
title_full_unstemmed	Nanoparticles for multimodal in vivo imaging in nanomedicine
title_sort	nanoparticles for multimodal in vivo imaging in nanomedicine
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/a2b6bd2050c549228d171806d934bc49
work_keys_str_mv	AT keyj nanoparticlesformultimodalinvivoimaginginnanomedicine AT learyjf nanoparticlesformultimodalinvivoimaginginnanomedicine
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Nanoparticles for multimodal in vivo imaging in nanomedicine

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