Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker

Abnormal folate metabolism in mice results in transgenerational epigenetic inheritance of congenital malformations. Here, the authors provide evidence that defective folate metabolism causes germline epigenetic instability and observe multigenerational misexpression of Hira in embryos, implicating H...

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Autores principales:	Georgina E. T. Blake, Xiaohui Zhao, Hong wa Yung, Graham J. Burton, Anne C. Ferguson-Smith, Russell S. Hamilton, Erica D. Watson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a2b6f87964694b4bad4140b486ce7efe
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spelling	oai:doaj.org-article:a2b6f87964694b4bad4140b486ce7efe2021-12-02T17:40:24ZDefective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker10.1038/s41467-021-24036-52041-1723https://doaj.org/article/a2b6f87964694b4bad4140b486ce7efe2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24036-5https://doaj.org/toc/2041-1723Abnormal folate metabolism in mice results in transgenerational epigenetic inheritance of congenital malformations. Here, the authors provide evidence that defective folate metabolism causes germline epigenetic instability and observe multigenerational misexpression of Hira in embryos, implicating Hira transcript levels as a biomarker of maternal phenotypic inheritance.Georgina E. T. BlakeXiaohui ZhaoHong wa YungGraham J. BurtonAnne C. Ferguson-SmithRussell S. HamiltonErica D. WatsonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Georgina E. T. Blake Xiaohui Zhao Hong wa Yung Graham J. Burton Anne C. Ferguson-Smith Russell S. Hamilton Erica D. Watson Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker
description	Abnormal folate metabolism in mice results in transgenerational epigenetic inheritance of congenital malformations. Here, the authors provide evidence that defective folate metabolism causes germline epigenetic instability and observe multigenerational misexpression of Hira in embryos, implicating Hira transcript levels as a biomarker of maternal phenotypic inheritance.
format	article
author	Georgina E. T. Blake Xiaohui Zhao Hong wa Yung Graham J. Burton Anne C. Ferguson-Smith Russell S. Hamilton Erica D. Watson
author_facet	Georgina E. T. Blake Xiaohui Zhao Hong wa Yung Graham J. Burton Anne C. Ferguson-Smith Russell S. Hamilton Erica D. Watson
author_sort	Georgina E. T. Blake
title	Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker
title_short	Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker
title_full	Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker
title_fullStr	Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker
title_full_unstemmed	Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker
title_sort	defective folate metabolism causes germline epigenetic instability and distinguishes hira as a phenotype inheritance biomarker
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a2b6f87964694b4bad4140b486ce7efe
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Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker

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