An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex

Hyperactivity of the gene NRAS contributes to the proliferation and metastatic nature of many types of cancer cells. Here, the authors show that NRAS can be controlled by an anionic phthalocyanine coordinating Zn2+ in combination with photo-irradiation.

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Autores principales:	Keiko Kawauchi, Wataru Sugimoto, Takatoshi Yasui, Kohei Murata, Katsuhiko Itoh, Kazuki Takagi, Takaaki Tsuruoka, Kensuke Akamatsu, Hisae Tateishi-Karimata, Naoki Sugimoto, Daisuke Miyoshi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a2b986b81e324fa785914b0394c35e22
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spelling	oai:doaj.org-article:a2b986b81e324fa785914b0394c35e222021-12-02T15:33:39ZAn anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex10.1038/s41467-018-04771-y2041-1723https://doaj.org/article/a2b986b81e324fa785914b0394c35e222018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04771-yhttps://doaj.org/toc/2041-1723Hyperactivity of the gene NRAS contributes to the proliferation and metastatic nature of many types of cancer cells. Here, the authors show that NRAS can be controlled by an anionic phthalocyanine coordinating Zn2+ in combination with photo-irradiation.Keiko KawauchiWataru SugimotoTakatoshi YasuiKohei MurataKatsuhiko ItohKazuki TakagiTakaaki TsuruokaKensuke AkamatsuHisae Tateishi-KarimataNaoki SugimotoDaisuke MiyoshiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Keiko Kawauchi Wataru Sugimoto Takatoshi Yasui Kohei Murata Katsuhiko Itoh Kazuki Takagi Takaaki Tsuruoka Kensuke Akamatsu Hisae Tateishi-Karimata Naoki Sugimoto Daisuke Miyoshi An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex
description	Hyperactivity of the gene NRAS contributes to the proliferation and metastatic nature of many types of cancer cells. Here, the authors show that NRAS can be controlled by an anionic phthalocyanine coordinating Zn2+ in combination with photo-irradiation.
format	article
author	Keiko Kawauchi Wataru Sugimoto Takatoshi Yasui Kohei Murata Katsuhiko Itoh Kazuki Takagi Takaaki Tsuruoka Kensuke Akamatsu Hisae Tateishi-Karimata Naoki Sugimoto Daisuke Miyoshi
author_facet	Keiko Kawauchi Wataru Sugimoto Takatoshi Yasui Kohei Murata Katsuhiko Itoh Kazuki Takagi Takaaki Tsuruoka Kensuke Akamatsu Hisae Tateishi-Karimata Naoki Sugimoto Daisuke Miyoshi
author_sort	Keiko Kawauchi
title	An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex
title_short	An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex
title_full	An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex
title_fullStr	An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex
title_full_unstemmed	An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex
title_sort	anionic phthalocyanine decreases nras expression by breaking down its rna g-quadruplex
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a2b986b81e324fa785914b0394c35e22
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An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex

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