An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex

An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex

Hyperactivity of the gene NRAS contributes to the proliferation and metastatic nature of many types of cancer cells. Here, the authors show that NRAS can be controlled by an anionic phthalocyanine coordinating Zn2+ in combination with photo-irradiation.

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Autores principales: Keiko Kawauchi, Wataru Sugimoto, Takatoshi Yasui, Kohei Murata, Katsuhiko Itoh, Kazuki Takagi, Takaaki Tsuruoka, Kensuke Akamatsu, Hisae Tateishi-Karimata, Naoki Sugimoto, Daisuke Miyoshi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
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Acceso en línea:https://doaj.org/article/a2b986b81e324fa785914b0394c35e22
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