MiR-125 Family in Cardiovascular and Cerebrovascular Diseases
Cardiovascular and cerebrovascular diseases are a serious threaten to the health of modern people. Understanding the mechanism of occurrence and development of cardiovascular and cerebrovascular diseases, as well as reasonable prevention and treatment of them, is a huge challenge that we are current...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:a2bcc276ae4b488a88e53166be6bf18f2021-12-02T10:06:49ZMiR-125 Family in Cardiovascular and Cerebrovascular Diseases2296-634X10.3389/fcell.2021.799049https://doaj.org/article/a2bcc276ae4b488a88e53166be6bf18f2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.799049/fullhttps://doaj.org/toc/2296-634XCardiovascular and cerebrovascular diseases are a serious threaten to the health of modern people. Understanding the mechanism of occurrence and development of cardiovascular and cerebrovascular diseases, as well as reasonable prevention and treatment of them, is a huge challenge that we are currently facing. The miR-125 family consists of hsa-miR-125a, hsa-miR-125b-1 and hsa-miR-125b-2. It is a kind of miRNA family that is highly conserved among different species. A large amount of literature shows that the lack of miR-125 can cause abnormal development of the cardiovascular system in the embryonic period. At the same time, the miR-125 family participates in the occurrence and development of a variety of cardiovascular and cerebrovascular diseases, including myocardial ischemia, atherosclerosis, ischemia-reperfusion injury, ischemic stroke, and heart failure directly or indirectly. In this article, we summarized the role of the miR-125 family in the development and maturation of cardiovascular system, the occurrence and development of cardiovascular and cerebrovascular diseases, and its important value in the current fiery stem cell therapy. In addition, we presented this in the form of table and diagrams. We also discussed the difficulties and challenges faced by the miR-125 family in clinical applications.Yang WangYang WangJing TanLu WangLu WangGaiqin PeiGaiqin PeiHongxin ChengHongxin ChengQing ZhangQing ZhangShiqi WangShiqi WangChengqi HeChengqi HeChenying FuChenying FuQuan WeiQuan WeiFrontiers Media S.A.articlecardiovascular and cerebrovascular diseasesmir-125atherosclerosismyocardial ischemiaischemia-reperfusionischemic strokeBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
cardiovascular and cerebrovascular diseases mir-125 atherosclerosis myocardial ischemia ischemia-reperfusion ischemic stroke Biology (General) QH301-705.5 |
| spellingShingle |
cardiovascular and cerebrovascular diseases mir-125 atherosclerosis myocardial ischemia ischemia-reperfusion ischemic stroke Biology (General) QH301-705.5 Yang Wang Yang Wang Jing Tan Lu Wang Lu Wang Gaiqin Pei Gaiqin Pei Hongxin Cheng Hongxin Cheng Qing Zhang Qing Zhang Shiqi Wang Shiqi Wang Chengqi He Chengqi He Chenying Fu Chenying Fu Quan Wei Quan Wei MiR-125 Family in Cardiovascular and Cerebrovascular Diseases |
| description |
Cardiovascular and cerebrovascular diseases are a serious threaten to the health of modern people. Understanding the mechanism of occurrence and development of cardiovascular and cerebrovascular diseases, as well as reasonable prevention and treatment of them, is a huge challenge that we are currently facing. The miR-125 family consists of hsa-miR-125a, hsa-miR-125b-1 and hsa-miR-125b-2. It is a kind of miRNA family that is highly conserved among different species. A large amount of literature shows that the lack of miR-125 can cause abnormal development of the cardiovascular system in the embryonic period. At the same time, the miR-125 family participates in the occurrence and development of a variety of cardiovascular and cerebrovascular diseases, including myocardial ischemia, atherosclerosis, ischemia-reperfusion injury, ischemic stroke, and heart failure directly or indirectly. In this article, we summarized the role of the miR-125 family in the development and maturation of cardiovascular system, the occurrence and development of cardiovascular and cerebrovascular diseases, and its important value in the current fiery stem cell therapy. In addition, we presented this in the form of table and diagrams. We also discussed the difficulties and challenges faced by the miR-125 family in clinical applications. |
| format |
article |
| author |
Yang Wang Yang Wang Jing Tan Lu Wang Lu Wang Gaiqin Pei Gaiqin Pei Hongxin Cheng Hongxin Cheng Qing Zhang Qing Zhang Shiqi Wang Shiqi Wang Chengqi He Chengqi He Chenying Fu Chenying Fu Quan Wei Quan Wei |
| author_facet |
Yang Wang Yang Wang Jing Tan Lu Wang Lu Wang Gaiqin Pei Gaiqin Pei Hongxin Cheng Hongxin Cheng Qing Zhang Qing Zhang Shiqi Wang Shiqi Wang Chengqi He Chengqi He Chenying Fu Chenying Fu Quan Wei Quan Wei |
| author_sort |
Yang Wang |
| title |
MiR-125 Family in Cardiovascular and Cerebrovascular Diseases |
| title_short |
MiR-125 Family in Cardiovascular and Cerebrovascular Diseases |
| title_full |
MiR-125 Family in Cardiovascular and Cerebrovascular Diseases |
| title_fullStr |
MiR-125 Family in Cardiovascular and Cerebrovascular Diseases |
| title_full_unstemmed |
MiR-125 Family in Cardiovascular and Cerebrovascular Diseases |
| title_sort |
mir-125 family in cardiovascular and cerebrovascular diseases |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/a2bcc276ae4b488a88e53166be6bf18f |
| work_keys_str_mv |
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| _version_ |
1718397646829256704 |