Resuscitative efficacy of hemoglobin vesicles for severe postpartum hemorrhage in pregnant rabbits

Abstract We aimed to investigate the resuscitative efficacy of hemoglobin vesicles (HbVs) as a red blood cell (RBC) substitute for the initial treatment of severe postpartum hemorrhage (PPH). Twenty-five pregnant rabbits underwent cesarean section; uncontrolled hemorrhage was induced by transecting...

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Autores principales:	Hiroki Ishibashi, Kohsuke Hagisawa, Manabu Kinoshita, Yukako Yuki, Morikazu Miyamoto, Tomoko Kure, Hiromi Sakai, Daizoh Saitoh, Katsuo Terui, Masashi Takano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a2bdc81d8b554053bc441c6ff5e5ea3b
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spelling	oai:doaj.org-article:a2bdc81d8b554053bc441c6ff5e5ea3b2021-11-21T12:24:29ZResuscitative efficacy of hemoglobin vesicles for severe postpartum hemorrhage in pregnant rabbits10.1038/s41598-021-01835-w2045-2322https://doaj.org/article/a2bdc81d8b554053bc441c6ff5e5ea3b2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01835-whttps://doaj.org/toc/2045-2322Abstract We aimed to investigate the resuscitative efficacy of hemoglobin vesicles (HbVs) as a red blood cell (RBC) substitute for the initial treatment of severe postpartum hemorrhage (PPH). Twenty-five pregnant rabbits underwent cesarean section; uncontrolled hemorrhage was induced by transecting the right uterine artery to establish a severe PPH model. During the first 30 min, all rabbits were administered 6% hydroxyethyl starch (HES) of an equivalent volume to the hemorrhage every 5 min. Thereafter, they received any of the following three isovolemic fluids for resuscitation every 5 min: RBCs with platelet-poor plasma (RBC/PPP) (n = 8), 6% HES (n = 7), or HbVs with 25% human serum albumin (n = 10). After surgical hemostasis at 60 min, survival was monitored until 12 h. No rabbits receiving only HES infusion survived beyond 6 h, whereas all rabbits receiving RBC/PPP transfusion survived. The rabbits receiving HbV infusion showed significantly higher mean arterial pressure and hemoglobin levels than the HES-receiving rabbits, and 8 of 10 rabbits survived for 6 h. The HbV group showed significantly higher survival than the HES group but worse survival than the RBC/PPP group. In conclusion, HbV infusion for severe PPH effectively prevents lethal hemorrhagic shock in a pregnant rabbit model.Hiroki IshibashiKohsuke HagisawaManabu KinoshitaYukako YukiMorikazu MiyamotoTomoko KureHiromi SakaiDaizoh SaitohKatsuo TeruiMasashi TakanoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hiroki Ishibashi Kohsuke Hagisawa Manabu Kinoshita Yukako Yuki Morikazu Miyamoto Tomoko Kure Hiromi Sakai Daizoh Saitoh Katsuo Terui Masashi Takano Resuscitative efficacy of hemoglobin vesicles for severe postpartum hemorrhage in pregnant rabbits
description	Abstract We aimed to investigate the resuscitative efficacy of hemoglobin vesicles (HbVs) as a red blood cell (RBC) substitute for the initial treatment of severe postpartum hemorrhage (PPH). Twenty-five pregnant rabbits underwent cesarean section; uncontrolled hemorrhage was induced by transecting the right uterine artery to establish a severe PPH model. During the first 30 min, all rabbits were administered 6% hydroxyethyl starch (HES) of an equivalent volume to the hemorrhage every 5 min. Thereafter, they received any of the following three isovolemic fluids for resuscitation every 5 min: RBCs with platelet-poor plasma (RBC/PPP) (n = 8), 6% HES (n = 7), or HbVs with 25% human serum albumin (n = 10). After surgical hemostasis at 60 min, survival was monitored until 12 h. No rabbits receiving only HES infusion survived beyond 6 h, whereas all rabbits receiving RBC/PPP transfusion survived. The rabbits receiving HbV infusion showed significantly higher mean arterial pressure and hemoglobin levels than the HES-receiving rabbits, and 8 of 10 rabbits survived for 6 h. The HbV group showed significantly higher survival than the HES group but worse survival than the RBC/PPP group. In conclusion, HbV infusion for severe PPH effectively prevents lethal hemorrhagic shock in a pregnant rabbit model.
format	article
author	Hiroki Ishibashi Kohsuke Hagisawa Manabu Kinoshita Yukako Yuki Morikazu Miyamoto Tomoko Kure Hiromi Sakai Daizoh Saitoh Katsuo Terui Masashi Takano
author_facet	Hiroki Ishibashi Kohsuke Hagisawa Manabu Kinoshita Yukako Yuki Morikazu Miyamoto Tomoko Kure Hiromi Sakai Daizoh Saitoh Katsuo Terui Masashi Takano
author_sort	Hiroki Ishibashi
title	Resuscitative efficacy of hemoglobin vesicles for severe postpartum hemorrhage in pregnant rabbits
title_short	Resuscitative efficacy of hemoglobin vesicles for severe postpartum hemorrhage in pregnant rabbits
title_full	Resuscitative efficacy of hemoglobin vesicles for severe postpartum hemorrhage in pregnant rabbits
title_fullStr	Resuscitative efficacy of hemoglobin vesicles for severe postpartum hemorrhage in pregnant rabbits
title_full_unstemmed	Resuscitative efficacy of hemoglobin vesicles for severe postpartum hemorrhage in pregnant rabbits
title_sort	resuscitative efficacy of hemoglobin vesicles for severe postpartum hemorrhage in pregnant rabbits
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a2bdc81d8b554053bc441c6ff5e5ea3b
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Resuscitative efficacy of hemoglobin vesicles for severe postpartum hemorrhage in pregnant rabbits

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