Application of 3D MAPs pipeline identifies the morphological sequence chondrocytes undergo and the regulatory role of GDF5 in this process

Inability to image large numbers of growth plate chondrocytes while retaining their spatial context during analysis has hindered the study of bone development. Here, the authors present a pipeline called 3D MAPs and use it to uncover morphogenic behaviors and growth strategies in normal bones as wel...

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Autores principales:	Sarah Rubin, Ankit Agrawal, Johannes Stegmaier, Sharon Krief, Neta Felsenthal, Jonathan Svorai, Yoseph Addadi, Paul Villoutreix, Tomer Stern, Elazar Zelzer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a2c40ff7191b44a3a1fdaee36adab733
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spelling	oai:doaj.org-article:a2c40ff7191b44a3a1fdaee36adab7332021-12-02T19:12:27ZApplication of 3D MAPs pipeline identifies the morphological sequence chondrocytes undergo and the regulatory role of GDF5 in this process10.1038/s41467-021-25714-02041-1723https://doaj.org/article/a2c40ff7191b44a3a1fdaee36adab7332021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25714-0https://doaj.org/toc/2041-1723Inability to image large numbers of growth plate chondrocytes while retaining their spatial context during analysis has hindered the study of bone development. Here, the authors present a pipeline called 3D MAPs and use it to uncover morphogenic behaviors and growth strategies in normal bones as well as aberrations in Gdf5 KO bones.Sarah RubinAnkit AgrawalJohannes StegmaierSharon KriefNeta FelsenthalJonathan SvoraiYoseph AddadiPaul VilloutreixTomer SternElazar ZelzerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sarah Rubin Ankit Agrawal Johannes Stegmaier Sharon Krief Neta Felsenthal Jonathan Svorai Yoseph Addadi Paul Villoutreix Tomer Stern Elazar Zelzer Application of 3D MAPs pipeline identifies the morphological sequence chondrocytes undergo and the regulatory role of GDF5 in this process
description	Inability to image large numbers of growth plate chondrocytes while retaining their spatial context during analysis has hindered the study of bone development. Here, the authors present a pipeline called 3D MAPs and use it to uncover morphogenic behaviors and growth strategies in normal bones as well as aberrations in Gdf5 KO bones.
format	article
author	Sarah Rubin Ankit Agrawal Johannes Stegmaier Sharon Krief Neta Felsenthal Jonathan Svorai Yoseph Addadi Paul Villoutreix Tomer Stern Elazar Zelzer
author_facet	Sarah Rubin Ankit Agrawal Johannes Stegmaier Sharon Krief Neta Felsenthal Jonathan Svorai Yoseph Addadi Paul Villoutreix Tomer Stern Elazar Zelzer
author_sort	Sarah Rubin
title	Application of 3D MAPs pipeline identifies the morphological sequence chondrocytes undergo and the regulatory role of GDF5 in this process
title_short	Application of 3D MAPs pipeline identifies the morphological sequence chondrocytes undergo and the regulatory role of GDF5 in this process
title_full	Application of 3D MAPs pipeline identifies the morphological sequence chondrocytes undergo and the regulatory role of GDF5 in this process
title_fullStr	Application of 3D MAPs pipeline identifies the morphological sequence chondrocytes undergo and the regulatory role of GDF5 in this process
title_full_unstemmed	Application of 3D MAPs pipeline identifies the morphological sequence chondrocytes undergo and the regulatory role of GDF5 in this process
title_sort	application of 3d maps pipeline identifies the morphological sequence chondrocytes undergo and the regulatory role of gdf5 in this process
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a2c40ff7191b44a3a1fdaee36adab733
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Application of 3D MAPs pipeline identifies the morphological sequence chondrocytes undergo and the regulatory role of GDF5 in this process

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