Nonlinear relationship between HbA1c and coronary artery calcium score progression: a secondary analysis based on a retrospective cohort study

Abstract Objective Coronary artery calcium score and glycated hemoglobin(HbA1c) are both considered risk factors for coronary heart disease. However, the relationship between coronary artery calcium score and HbA1c is still unclear. Consequently, the present study was undertaken to explore HbA1c ass...

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Autores principales:	Jing Yu, Bo Gao
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Glycated hemoglobin Coronary artery calcium score Coronary atherosclerotic heart disease Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/a2c6cd6b3a5b4ec5aec0721796ebee6f
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spelling	oai:doaj.org-article:a2c6cd6b3a5b4ec5aec0721796ebee6f2021-11-21T12:40:17ZNonlinear relationship between HbA1c and coronary artery calcium score progression: a secondary analysis based on a retrospective cohort study10.1186/s13098-021-00747-z1758-5996https://doaj.org/article/a2c6cd6b3a5b4ec5aec0721796ebee6f2021-11-01T00:00:00Zhttps://doi.org/10.1186/s13098-021-00747-zhttps://doaj.org/toc/1758-5996Abstract Objective Coronary artery calcium score and glycated hemoglobin(HbA1c) are both considered risk factors for coronary heart disease. However, the relationship between coronary artery calcium score and HbA1c is still unclear. Consequently, the present study was undertaken to explore HbA1c association with coronary artery calcium score progression in South Korea. Methods This study is a secondary analysis based on a retrospective cohort study in which 8151 participants received Health examination kits at the Health Promotion Center, Samsung Medical Center in Seoul, South Korea, from March 1, 2003–December 31, 2013. Cox proportional-hazards regression model was then used to evaluate the independent relationship between HbA1c and coronary artery calcium score progression. Results After adjusting potential confounding factors (age, sex, BMI, height, weight, SBP, DBP, TC, LDL-C, HDL-C, triglycerides, smoking status, alcohol consumption, reflux esophagitis status, hypertension, diabetes, dyslipidemia, ischemic heart disease and cerebrovascular disease), it was revealed that there was a nonlinear relationship between HbA1c and coronary artery calcium score progression, while the scoring point was 5.8%. The effect size was 2.06 to the left of the inflection point, while the 95% CI was 1.85 to 2.29. Whereas, the effect size was 1.04, on the right side of the inflection point while 95% CI was 0.99 to1.10. Conclusion The relationship between HbA1c and coronary artery calcium score progression is nonlinear. HbA1c is positively related to coronary artery calcium score progression when HbA1c level was less than 5.8%.Jing YuBo GaoBMCarticleGlycated hemoglobinCoronary artery calcium scoreCoronary atherosclerotic heart diseaseNutritional diseases. Deficiency diseasesRC620-627ENDiabetology & Metabolic Syndrome, Vol 13, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Glycated hemoglobin Coronary artery calcium score Coronary atherosclerotic heart disease Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	Glycated hemoglobin Coronary artery calcium score Coronary atherosclerotic heart disease Nutritional diseases. Deficiency diseases RC620-627 Jing Yu Bo Gao Nonlinear relationship between HbA1c and coronary artery calcium score progression: a secondary analysis based on a retrospective cohort study
description	Abstract Objective Coronary artery calcium score and glycated hemoglobin(HbA1c) are both considered risk factors for coronary heart disease. However, the relationship between coronary artery calcium score and HbA1c is still unclear. Consequently, the present study was undertaken to explore HbA1c association with coronary artery calcium score progression in South Korea. Methods This study is a secondary analysis based on a retrospective cohort study in which 8151 participants received Health examination kits at the Health Promotion Center, Samsung Medical Center in Seoul, South Korea, from March 1, 2003–December 31, 2013. Cox proportional-hazards regression model was then used to evaluate the independent relationship between HbA1c and coronary artery calcium score progression. Results After adjusting potential confounding factors (age, sex, BMI, height, weight, SBP, DBP, TC, LDL-C, HDL-C, triglycerides, smoking status, alcohol consumption, reflux esophagitis status, hypertension, diabetes, dyslipidemia, ischemic heart disease and cerebrovascular disease), it was revealed that there was a nonlinear relationship between HbA1c and coronary artery calcium score progression, while the scoring point was 5.8%. The effect size was 2.06 to the left of the inflection point, while the 95% CI was 1.85 to 2.29. Whereas, the effect size was 1.04, on the right side of the inflection point while 95% CI was 0.99 to1.10. Conclusion The relationship between HbA1c and coronary artery calcium score progression is nonlinear. HbA1c is positively related to coronary artery calcium score progression when HbA1c level was less than 5.8%.
format	article
author	Jing Yu Bo Gao
author_facet	Jing Yu Bo Gao
author_sort	Jing Yu
title	Nonlinear relationship between HbA1c and coronary artery calcium score progression: a secondary analysis based on a retrospective cohort study
title_short	Nonlinear relationship between HbA1c and coronary artery calcium score progression: a secondary analysis based on a retrospective cohort study
title_full	Nonlinear relationship between HbA1c and coronary artery calcium score progression: a secondary analysis based on a retrospective cohort study
title_fullStr	Nonlinear relationship between HbA1c and coronary artery calcium score progression: a secondary analysis based on a retrospective cohort study
title_full_unstemmed	Nonlinear relationship between HbA1c and coronary artery calcium score progression: a secondary analysis based on a retrospective cohort study
title_sort	nonlinear relationship between hba1c and coronary artery calcium score progression: a secondary analysis based on a retrospective cohort study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/a2c6cd6b3a5b4ec5aec0721796ebee6f
work_keys_str_mv	AT jingyu nonlinearrelationshipbetweenhba1candcoronaryarterycalciumscoreprogressionasecondaryanalysisbasedonaretrospectivecohortstudy AT bogao nonlinearrelationshipbetweenhba1candcoronaryarterycalciumscoreprogressionasecondaryanalysisbasedonaretrospectivecohortstudy
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Nonlinear relationship between HbA1c and coronary artery calcium score progression: a secondary analysis based on a retrospective cohort study

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