Characteristics in gut microbiome is associated with chemotherapy-induced pneumonia in pediatric acute lymphoblastic leukemia

Abstract Background Children with acute lymphoblastic leukemia (ALL) undergoing chemotherapy experience a relatively high risk of infection. And the disturbance of gut microbiota is generally believed to impair intestinal barrier function and may induce bacterial infections and inflammation. The stu...

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Autores principales:	Xiaoming Liu, Yao Zou, Yingchi Zhang, Lipeng Liu, Yongjuan Duan, Aoli Zhang, Xiaoyan Zhang, Ranran Zhang, Beibei Zhao, Xiaolan Li, Tong Wei, Hongrui He, Yu Gan, Kejian Wang, Xiaofan Zhu
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Pediatric acute lymphoblastic leukemia Chemotherapy-induced pneumonia Gut microbiome 16S rRNA quantitative microarray Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/a2c89696439d4c13884671dab30124ab
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spelling	oai:doaj.org-article:a2c89696439d4c13884671dab30124ab2021-11-14T12:30:16ZCharacteristics in gut microbiome is associated with chemotherapy-induced pneumonia in pediatric acute lymphoblastic leukemia10.1186/s12885-021-08917-y1471-2407https://doaj.org/article/a2c89696439d4c13884671dab30124ab2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12885-021-08917-yhttps://doaj.org/toc/1471-2407Abstract Background Children with acute lymphoblastic leukemia (ALL) undergoing chemotherapy experience a relatively high risk of infection. And the disturbance of gut microbiota is generally believed to impair intestinal barrier function and may induce bacterial infections and inflammation. The study aimed to investigate the alterations in the gut microbiota and assess its relationship with chemotherapy-induced pneumonia in pediatric ALL patients. Methods We conducted a case–control study with 14 cases affected by pneumonia and 44 unaffected subjects and characterized the physiological parameters and gut microbiota by microarray-based technique. Results There were significant differences in α- and β-diversity in the affected group compared with the control group. At species level, the LEfSe analysis revealed that Enterococcus malodoratus, Ochrobactrum anthropi and Actinomyces cardiffensis were significantly abundant in the affected subjects. A receiver operating characteristic (ROC) curve yielded the area under the curve (AUC) of 0.773 for classification between the two groups. In addition, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways involved in the bacterial secretion system were more enriched in the affected group than in the control group. Conclusions Gut microbiota alteration was associated with chemotherapy-induced pneumonia in pediatric ALL patients, which provided a new perspective on the personalized clinical care of pediatric ALL.Xiaoming LiuYao ZouYingchi ZhangLipeng LiuYongjuan DuanAoli ZhangXiaoyan ZhangRanran ZhangBeibei ZhaoXiaolan LiTong WeiHongrui HeYu GanKejian WangXiaofan ZhuBMCarticlePediatric acute lymphoblastic leukemiaChemotherapy-induced pneumoniaGut microbiome16S rRNA quantitative microarrayNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBMC Cancer, Vol 21, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pediatric acute lymphoblastic leukemia Chemotherapy-induced pneumonia Gut microbiome 16S rRNA quantitative microarray Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Pediatric acute lymphoblastic leukemia Chemotherapy-induced pneumonia Gut microbiome 16S rRNA quantitative microarray Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Xiaoming Liu Yao Zou Yingchi Zhang Lipeng Liu Yongjuan Duan Aoli Zhang Xiaoyan Zhang Ranran Zhang Beibei Zhao Xiaolan Li Tong Wei Hongrui He Yu Gan Kejian Wang Xiaofan Zhu Characteristics in gut microbiome is associated with chemotherapy-induced pneumonia in pediatric acute lymphoblastic leukemia
description	Abstract Background Children with acute lymphoblastic leukemia (ALL) undergoing chemotherapy experience a relatively high risk of infection. And the disturbance of gut microbiota is generally believed to impair intestinal barrier function and may induce bacterial infections and inflammation. The study aimed to investigate the alterations in the gut microbiota and assess its relationship with chemotherapy-induced pneumonia in pediatric ALL patients. Methods We conducted a case–control study with 14 cases affected by pneumonia and 44 unaffected subjects and characterized the physiological parameters and gut microbiota by microarray-based technique. Results There were significant differences in α- and β-diversity in the affected group compared with the control group. At species level, the LEfSe analysis revealed that Enterococcus malodoratus, Ochrobactrum anthropi and Actinomyces cardiffensis were significantly abundant in the affected subjects. A receiver operating characteristic (ROC) curve yielded the area under the curve (AUC) of 0.773 for classification between the two groups. In addition, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways involved in the bacterial secretion system were more enriched in the affected group than in the control group. Conclusions Gut microbiota alteration was associated with chemotherapy-induced pneumonia in pediatric ALL patients, which provided a new perspective on the personalized clinical care of pediatric ALL.
format	article
author	Xiaoming Liu Yao Zou Yingchi Zhang Lipeng Liu Yongjuan Duan Aoli Zhang Xiaoyan Zhang Ranran Zhang Beibei Zhao Xiaolan Li Tong Wei Hongrui He Yu Gan Kejian Wang Xiaofan Zhu
author_facet	Xiaoming Liu Yao Zou Yingchi Zhang Lipeng Liu Yongjuan Duan Aoli Zhang Xiaoyan Zhang Ranran Zhang Beibei Zhao Xiaolan Li Tong Wei Hongrui He Yu Gan Kejian Wang Xiaofan Zhu
author_sort	Xiaoming Liu
title	Characteristics in gut microbiome is associated with chemotherapy-induced pneumonia in pediatric acute lymphoblastic leukemia
title_short	Characteristics in gut microbiome is associated with chemotherapy-induced pneumonia in pediatric acute lymphoblastic leukemia
title_full	Characteristics in gut microbiome is associated with chemotherapy-induced pneumonia in pediatric acute lymphoblastic leukemia
title_fullStr	Characteristics in gut microbiome is associated with chemotherapy-induced pneumonia in pediatric acute lymphoblastic leukemia
title_full_unstemmed	Characteristics in gut microbiome is associated with chemotherapy-induced pneumonia in pediatric acute lymphoblastic leukemia
title_sort	characteristics in gut microbiome is associated with chemotherapy-induced pneumonia in pediatric acute lymphoblastic leukemia
publisher	BMC
publishDate	2021
url	https://doaj.org/article/a2c89696439d4c13884671dab30124ab
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Characteristics in gut microbiome is associated with chemotherapy-induced pneumonia in pediatric acute lymphoblastic leukemia

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