Development of resveratrol-conjugated gold nanoparticles: interrelationship of increased resveratrol corona on anti-tumor efficacy against breast, pancreatic and prostate cancers

Velaphi C Thipe,1,2 Kiandohkt Panjtan Amiri,3 Pierce Bloebaum,2,4 Alice Raphael Karikachery,2,5 Menka Khoobchandani,2,5 Kavita K Katti,2,5 Silvia S Jurisson,1,6 Kattesh V Katti2,4–71Department of Chemistry, University of Missouri, Columbia, MO 65201, USA; 2Institute of Green Nanotechnology...

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Autores principales:	Thipe VC, Panjtan Amiri K, Bloebaum P, Raphael Karikachery A, Khoobchandani M, Katti KK, Jurisson SS, Katti KV
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Resveratrol gold nanoparticles corona green nanotechnology breast pancreatic prostate. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a2c8a622cb314b2b8a7dfff0ad333619
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spelling	oai:doaj.org-article:a2c8a622cb314b2b8a7dfff0ad3336192021-12-02T01:11:58ZDevelopment of resveratrol-conjugated gold nanoparticles: interrelationship of increased resveratrol corona on anti-tumor efficacy against breast, pancreatic and prostate cancers1178-2013https://doaj.org/article/a2c8a622cb314b2b8a7dfff0ad3336192019-06-01T00:00:00Zhttps://www.dovepress.com/development-of-resveratrol-conjugated-gold-nanoparticles-interrelation-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Velaphi C Thipe,1,2 Kiandohkt Panjtan Amiri,3 Pierce Bloebaum,2,4 Alice Raphael Karikachery,2,5 Menka Khoobchandani,2,5 Kavita K Katti,2,5 Silvia S Jurisson,1,6 Kattesh V Katti2,4–71Department of Chemistry, University of Missouri, Columbia, MO 65201, USA; 2Institute of Green Nanotechnology, University of Missouri, Columbia, MO 65211, USA; 3Department of Physics, Washington University, St. Louis, MO 63130, USA; 4Department of Physics and Astronomy; 5Department of Radiology; 6University of Missouri Research Reactor, University of Missouri, Columbia, MO 65211, USA; 7Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65211, USABackground: As part of our continuing quest to enhance the efficacy of bioactive phytochemicals in cancer therapy, we report an innovative green nanotechnology approach toward the use of resveratrol for the production of biocompatible resveratrol-conjugated gold nanoparticles (Res-AuNPs). Our overarching aim is to exploit the inherent pro-apoptotic properties of gold nanoparticles (AuNPs) through synergistic anti-tumor characteristics of resveratrol, with the aim of developing a new class of green nanotechnology-based phytochemical-embedded AuNPs for applications in oncology.Method: Resveratrol was used to reduce Au3+, to Au0, for the synthesis of Res-AuNPs at room temperature and gum arabic (GA) was used to further encapsulate the nanoparticulate surface to increase the overall stability of the AuNPs. This comprehensive study involves the synthesis, full characterization and in vitro stability of Res-AuNPs in various biological media for their ultimate applications as anti-cancer agents against human breast (MDAMB-231), pancreatic (PANC-1) and prostate (PC-3) cancers.Results: This strategy to systematically increase the corona of resveratrol on AuNPs, in order to gain insights into the interrelationship of the phytochemical corona on the overall anti-tumor activities of Res-AuNPs, proved successful. The increased resveratrol corona on Res-AuNPs showed superior anti-cancer effects, attributed to an optimal cellular uptake after 24-hour incubation, while GA provided a protein matrix support for enhanced trans-resveratrol loading onto the surface of the AuNPs.Conclusion: The approach described in this study harnesses the benefits of nutraceuticals and nanoparticles toward the development of Res-AuNPs. We provide compelling evidence that the increased corona of resveratrol on AuNPs enhances the bioavailability of resveratrol so that therapeutically active species can be optimally available in vivo for applications in cancer therapy.Keywords: resveratrol, gold nanoparticles, nanotechnology, cancer therapyThipe VCPanjtan Amiri KBloebaum PRaphael Karikachery AKhoobchandani MKatti KKJurisson SSKatti KVDove Medical PressarticleResveratrolgold nanoparticlescoronagreen nanotechnologybreastpancreaticprostate.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 4413-4428 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Resveratrol gold nanoparticles corona green nanotechnology breast pancreatic prostate. Medicine (General) R5-920
spellingShingle	Resveratrol gold nanoparticles corona green nanotechnology breast pancreatic prostate. Medicine (General) R5-920 Thipe VC Panjtan Amiri K Bloebaum P Raphael Karikachery A Khoobchandani M Katti KK Jurisson SS Katti KV Development of resveratrol-conjugated gold nanoparticles: interrelationship of increased resveratrol corona on anti-tumor efficacy against breast, pancreatic and prostate cancers
description	Velaphi C Thipe,1,2 Kiandohkt Panjtan Amiri,3 Pierce Bloebaum,2,4 Alice Raphael Karikachery,2,5 Menka Khoobchandani,2,5 Kavita K Katti,2,5 Silvia S Jurisson,1,6 Kattesh V Katti2,4–71Department of Chemistry, University of Missouri, Columbia, MO 65201, USA; 2Institute of Green Nanotechnology, University of Missouri, Columbia, MO 65211, USA; 3Department of Physics, Washington University, St. Louis, MO 63130, USA; 4Department of Physics and Astronomy; 5Department of Radiology; 6University of Missouri Research Reactor, University of Missouri, Columbia, MO 65211, USA; 7Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65211, USABackground: As part of our continuing quest to enhance the efficacy of bioactive phytochemicals in cancer therapy, we report an innovative green nanotechnology approach toward the use of resveratrol for the production of biocompatible resveratrol-conjugated gold nanoparticles (Res-AuNPs). Our overarching aim is to exploit the inherent pro-apoptotic properties of gold nanoparticles (AuNPs) through synergistic anti-tumor characteristics of resveratrol, with the aim of developing a new class of green nanotechnology-based phytochemical-embedded AuNPs for applications in oncology.Method: Resveratrol was used to reduce Au3+, to Au0, for the synthesis of Res-AuNPs at room temperature and gum arabic (GA) was used to further encapsulate the nanoparticulate surface to increase the overall stability of the AuNPs. This comprehensive study involves the synthesis, full characterization and in vitro stability of Res-AuNPs in various biological media for their ultimate applications as anti-cancer agents against human breast (MDAMB-231), pancreatic (PANC-1) and prostate (PC-3) cancers.Results: This strategy to systematically increase the corona of resveratrol on AuNPs, in order to gain insights into the interrelationship of the phytochemical corona on the overall anti-tumor activities of Res-AuNPs, proved successful. The increased resveratrol corona on Res-AuNPs showed superior anti-cancer effects, attributed to an optimal cellular uptake after 24-hour incubation, while GA provided a protein matrix support for enhanced trans-resveratrol loading onto the surface of the AuNPs.Conclusion: The approach described in this study harnesses the benefits of nutraceuticals and nanoparticles toward the development of Res-AuNPs. We provide compelling evidence that the increased corona of resveratrol on AuNPs enhances the bioavailability of resveratrol so that therapeutically active species can be optimally available in vivo for applications in cancer therapy.Keywords: resveratrol, gold nanoparticles, nanotechnology, cancer therapy
format	article
author	Thipe VC Panjtan Amiri K Bloebaum P Raphael Karikachery A Khoobchandani M Katti KK Jurisson SS Katti KV
author_facet	Thipe VC Panjtan Amiri K Bloebaum P Raphael Karikachery A Khoobchandani M Katti KK Jurisson SS Katti KV
author_sort	Thipe VC
title	Development of resveratrol-conjugated gold nanoparticles: interrelationship of increased resveratrol corona on anti-tumor efficacy against breast, pancreatic and prostate cancers
title_short	Development of resveratrol-conjugated gold nanoparticles: interrelationship of increased resveratrol corona on anti-tumor efficacy against breast, pancreatic and prostate cancers
title_full	Development of resveratrol-conjugated gold nanoparticles: interrelationship of increased resveratrol corona on anti-tumor efficacy against breast, pancreatic and prostate cancers
title_fullStr	Development of resveratrol-conjugated gold nanoparticles: interrelationship of increased resveratrol corona on anti-tumor efficacy against breast, pancreatic and prostate cancers
title_full_unstemmed	Development of resveratrol-conjugated gold nanoparticles: interrelationship of increased resveratrol corona on anti-tumor efficacy against breast, pancreatic and prostate cancers
title_sort	development of resveratrol-conjugated gold nanoparticles: interrelationship of increased resveratrol corona on anti-tumor efficacy against breast, pancreatic and prostate cancers
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/a2c8a622cb314b2b8a7dfff0ad333619
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Development of resveratrol-conjugated gold nanoparticles: interrelationship of increased resveratrol corona on anti-tumor efficacy against breast, pancreatic and prostate cancers

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