Changes in urinary nanocrystallites in calcium oxalate stone formers before and after potassium citrate intake

Chao-Yang Duan,1 Zhi-Yue Xia,2 Guang-Na Zhang,2 Bao-Song Gui,1 Jun-Fa Xue,2 Jian-Ming Ouyang21Department of Nephrology, the Second Hospital of Xi&#39;an Jiaotong University, Xi&#39;an, People&#39;s Republic of China; 2Institute of Biomineralization and Lithiasis Research, Jin...

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Autores principales:	Duan CY, Xia ZY, Zhang GN, Gui BS, Xue JF, Ouyang JM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a2cb37261f5b4286a311af050c270109
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spelling	oai:doaj.org-article:a2cb37261f5b4286a311af050c2701092021-12-02T07:20:22ZChanges in urinary nanocrystallites in calcium oxalate stone formers before and after potassium citrate intake1176-91141178-2013https://doaj.org/article/a2cb37261f5b4286a311af050c2701092013-03-01T00:00:00Zhttp://www.dovepress.com/changes-in-urinary-nanocrystallites-in-calcium-oxalate-stone-formers-b-a12340https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Chao-Yang Duan,1 Zhi-Yue Xia,2 Guang-Na Zhang,2 Bao-Song Gui,1 Jun-Fa Xue,2 Jian-Ming Ouyang21Department of Nephrology, the Second Hospital of Xi&#39;an Jiaotong University, Xi&#39;an, People&#39;s Republic of China; 2Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou, People&#39;s Republic of ChinaAbstract: The property changes of urinary nanocrystallites in 13 patients with calcium oxalate (CaOx) stones were studied before and after ingestion of potassium citrate (K3cit), a therapeutic drug for stones. The analytical techniques included nanoparticle size analysis, transmission electron microscopy, X-ray diffraction, and Fourier-transform infrared spectroscopy. The studied properties included the components, morphologies, zeta potentials, particle size distributions, light intensity autocorrelation curves, and polydispersity indices (PDIs) of the nanocrystallites. The main components of the urinary nanocrystallites before K3cit intake included uric acid, &beta;-calcium phosphate, and calcium oxalate monohydrate. After K3cit intake, the quantities, species, and percentages of aggregated crystals decreased, whereas the percentages of monosodium urate and calcium oxalate dehydrate increased, and some crystallites became blunt. Moreover, the urinary pH increased from 5.96 &plusmn; 0.43 to 6.46 &plusmn; 0.50, the crystallite size decreased from 524 &plusmn; 320 nm to 354 &plusmn; 173 nm, and the zeta potential decreased from &minus;4.85 &plusmn; 2.87 mV to &minus;8.77 &plusmn; 3.03 mV. The autocorrelation curves became smooth, the decay time decreased from 11.4 &plusmn; 3.2 ms to 4.3 &plusmn; 1.7 ms, and the PDI decreased from 0.67 &plusmn; 0.14 to 0.53 &plusmn; 0.19. These changes helped inhibit CaOx calculus formation.Keywords: nanotechnology, zeta potential, aggregationDuan CYXia ZYZhang GNGui BSXue JFOuyang JMDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 909-918 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Duan CY Xia ZY Zhang GN Gui BS Xue JF Ouyang JM Changes in urinary nanocrystallites in calcium oxalate stone formers before and after potassium citrate intake
description	Chao-Yang Duan,1 Zhi-Yue Xia,2 Guang-Na Zhang,2 Bao-Song Gui,1 Jun-Fa Xue,2 Jian-Ming Ouyang21Department of Nephrology, the Second Hospital of Xi&#39;an Jiaotong University, Xi&#39;an, People&#39;s Republic of China; 2Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou, People&#39;s Republic of ChinaAbstract: The property changes of urinary nanocrystallites in 13 patients with calcium oxalate (CaOx) stones were studied before and after ingestion of potassium citrate (K3cit), a therapeutic drug for stones. The analytical techniques included nanoparticle size analysis, transmission electron microscopy, X-ray diffraction, and Fourier-transform infrared spectroscopy. The studied properties included the components, morphologies, zeta potentials, particle size distributions, light intensity autocorrelation curves, and polydispersity indices (PDIs) of the nanocrystallites. The main components of the urinary nanocrystallites before K3cit intake included uric acid, &beta;-calcium phosphate, and calcium oxalate monohydrate. After K3cit intake, the quantities, species, and percentages of aggregated crystals decreased, whereas the percentages of monosodium urate and calcium oxalate dehydrate increased, and some crystallites became blunt. Moreover, the urinary pH increased from 5.96 &plusmn; 0.43 to 6.46 &plusmn; 0.50, the crystallite size decreased from 524 &plusmn; 320 nm to 354 &plusmn; 173 nm, and the zeta potential decreased from &minus;4.85 &plusmn; 2.87 mV to &minus;8.77 &plusmn; 3.03 mV. The autocorrelation curves became smooth, the decay time decreased from 11.4 &plusmn; 3.2 ms to 4.3 &plusmn; 1.7 ms, and the PDI decreased from 0.67 &plusmn; 0.14 to 0.53 &plusmn; 0.19. These changes helped inhibit CaOx calculus formation.Keywords: nanotechnology, zeta potential, aggregation
format	article
author	Duan CY Xia ZY Zhang GN Gui BS Xue JF Ouyang JM
author_facet	Duan CY Xia ZY Zhang GN Gui BS Xue JF Ouyang JM
author_sort	Duan CY
title	Changes in urinary nanocrystallites in calcium oxalate stone formers before and after potassium citrate intake
title_short	Changes in urinary nanocrystallites in calcium oxalate stone formers before and after potassium citrate intake
title_full	Changes in urinary nanocrystallites in calcium oxalate stone formers before and after potassium citrate intake
title_fullStr	Changes in urinary nanocrystallites in calcium oxalate stone formers before and after potassium citrate intake
title_full_unstemmed	Changes in urinary nanocrystallites in calcium oxalate stone formers before and after potassium citrate intake
title_sort	changes in urinary nanocrystallites in calcium oxalate stone formers before and after potassium citrate intake
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/a2cb37261f5b4286a311af050c270109
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Changes in urinary nanocrystallites in calcium oxalate stone formers before and after potassium citrate intake

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