Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells

Aged hematopoietic stem cells (HSC) are characterised by reduced regenerative potential and a loss of quiescence. Here, the authors show nicotinamide riboside treatment shrinks the age-enlarged stem cell pool and shifts aged HSC functionally, metabolically and molecularly towards the young state.

Guardado en:

Detalles Bibliográficos
Autores principales:	Xuan Sun, Benjamin Cao, Marina Naval-Sanchez, Tony Pham, Yu Bo Yang Sun, Brenda Williams, Shen Y. Heazlewood, Nikita Deshpande, Jinhua Li, Felix Kraus, James Rae, Quan Nguyen, Hamed Yari, Jan Schröder, Chad K. Heazlewood, Madeline Fulton, Jessica Hatwell-Humble, Kaustav Das Gupta, Ronan Kapetanovic, Xiaoli Chen, Matthew J. Sweet, Robert G. Parton, Michael T. Ryan, Jose M. Polo, Christian M. Nefzger, Susan K. Nilsson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a2cd09ff347c4623848c6acc6789d348
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a2cd09ff347c4623848c6acc6789d348
record_format	dspace
spelling	oai:doaj.org-article:a2cd09ff347c4623848c6acc6789d3482021-12-02T17:02:20ZNicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells10.1038/s41467-021-22863-02041-1723https://doaj.org/article/a2cd09ff347c4623848c6acc6789d3482021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22863-0https://doaj.org/toc/2041-1723Aged hematopoietic stem cells (HSC) are characterised by reduced regenerative potential and a loss of quiescence. Here, the authors show nicotinamide riboside treatment shrinks the age-enlarged stem cell pool and shifts aged HSC functionally, metabolically and molecularly towards the young state.Xuan SunBenjamin CaoMarina Naval-SanchezTony PhamYu Bo Yang SunBrenda WilliamsShen Y. HeazlewoodNikita DeshpandeJinhua LiFelix KrausJames RaeQuan NguyenHamed YariJan SchröderChad K. HeazlewoodMadeline FultonJessica Hatwell-HumbleKaustav Das GuptaRonan KapetanovicXiaoli ChenMatthew J. SweetRobert G. PartonMichael T. RyanJose M. PoloChristian M. NefzgerSusan K. NilssonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xuan Sun Benjamin Cao Marina Naval-Sanchez Tony Pham Yu Bo Yang Sun Brenda Williams Shen Y. Heazlewood Nikita Deshpande Jinhua Li Felix Kraus James Rae Quan Nguyen Hamed Yari Jan Schröder Chad K. Heazlewood Madeline Fulton Jessica Hatwell-Humble Kaustav Das Gupta Ronan Kapetanovic Xiaoli Chen Matthew J. Sweet Robert G. Parton Michael T. Ryan Jose M. Polo Christian M. Nefzger Susan K. Nilsson Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells
description	Aged hematopoietic stem cells (HSC) are characterised by reduced regenerative potential and a loss of quiescence. Here, the authors show nicotinamide riboside treatment shrinks the age-enlarged stem cell pool and shifts aged HSC functionally, metabolically and molecularly towards the young state.
format	article
author	Xuan Sun Benjamin Cao Marina Naval-Sanchez Tony Pham Yu Bo Yang Sun Brenda Williams Shen Y. Heazlewood Nikita Deshpande Jinhua Li Felix Kraus James Rae Quan Nguyen Hamed Yari Jan Schröder Chad K. Heazlewood Madeline Fulton Jessica Hatwell-Humble Kaustav Das Gupta Ronan Kapetanovic Xiaoli Chen Matthew J. Sweet Robert G. Parton Michael T. Ryan Jose M. Polo Christian M. Nefzger Susan K. Nilsson
author_facet	Xuan Sun Benjamin Cao Marina Naval-Sanchez Tony Pham Yu Bo Yang Sun Brenda Williams Shen Y. Heazlewood Nikita Deshpande Jinhua Li Felix Kraus James Rae Quan Nguyen Hamed Yari Jan Schröder Chad K. Heazlewood Madeline Fulton Jessica Hatwell-Humble Kaustav Das Gupta Ronan Kapetanovic Xiaoli Chen Matthew J. Sweet Robert G. Parton Michael T. Ryan Jose M. Polo Christian M. Nefzger Susan K. Nilsson
author_sort	Xuan Sun
title	Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells
title_short	Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells
title_full	Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells
title_fullStr	Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells
title_full_unstemmed	Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells
title_sort	nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a2cd09ff347c4623848c6acc6789d348
work_keys_str_mv	AT xuansun nicotinamideribosideattenuatesageassociatedmetabolicandfunctionalchangesinhematopoieticstemcells AT benjamincao nicotinamideribosideattenuatesageassociatedmetabolicandfunctionalchangesinhematopoieticstemcells AT marinanavalsanchez nicotinamideribosideattenuatesageassociatedmetabolicandfunctionalchangesinhematopoieticstemcells AT tonypham nicotinamideribosideattenuatesageassociatedmetabolicandfunctionalchangesinhematopoieticstemcells AT yuboyangsun nicotinamideribosideattenuatesageassociatedmetabolicandfunctionalchangesinhematopoieticstemcells AT brendawilliams nicotinamideribosideattenuatesageassociatedmetabolicandfunctionalchangesinhematopoieticstemcells AT shenyheazlewood nicotinamideribosideattenuatesageassociatedmetabolicandfunctionalchangesinhematopoieticstemcells AT nikitadeshpande nicotinamideribosideattenuatesageassociatedmetabolicandfunctionalchangesinhematopoieticstemcells AT jinhuali nicotinamideribosideattenuatesageassociatedmetabolicandfunctionalchangesinhematopoieticstemcells AT felixkraus nicotinamideribosideattenuatesageassociatedmetabolicandfunctionalchangesinhematopoieticstemcells AT jamesrae nicotinamideribosideattenuatesageassociatedmetabolicandfunctionalchangesinhematopoieticstemcells AT quannguyen nicotinamideribosideattenuatesageassociatedmetabolicandfunctionalchangesinhematopoieticstemcells AT hamedyari nicotinamideribosideattenuatesageassociatedmetabolicandfunctionalchangesinhematopoieticstemcells AT janschroder nicotinamideribosideattenuatesageassociatedmetabolicandfunctionalchangesinhematopoieticstemcells AT chadkheazlewood nicotinamideribosideattenuatesageassociatedmetabolicandfunctionalchangesinhematopoieticstemcells AT madelinefulton nicotinamideribosideattenuatesageassociatedmetabolicandfunctionalchangesinhematopoieticstemcells AT jessicahatwellhumble nicotinamideribosideattenuatesageassociatedmetabolicandfunctionalchangesinhematopoieticstemcells AT kaustavdasgupta nicotinamideribosideattenuatesageassociatedmetabolicandfunctionalchangesinhematopoieticstemcells AT ronankapetanovic nicotinamideribosideattenuatesageassociatedmetabolicandfunctionalchangesinhematopoieticstemcells AT xiaolichen nicotinamideribosideattenuatesageassociatedmetabolicandfunctionalchangesinhematopoieticstemcells AT matthewjsweet nicotinamideribosideattenuatesageassociatedmetabolicandfunctionalchangesinhematopoieticstemcells AT robertgparton nicotinamideribosideattenuatesageassociatedmetabolicandfunctionalchangesinhematopoieticstemcells AT michaeltryan nicotinamideribosideattenuatesageassociatedmetabolicandfunctionalchangesinhematopoieticstemcells AT josempolo nicotinamideribosideattenuatesageassociatedmetabolicandfunctionalchangesinhematopoieticstemcells AT christianmnefzger nicotinamideribosideattenuatesageassociatedmetabolicandfunctionalchangesinhematopoieticstemcells AT susanknilsson nicotinamideribosideattenuatesageassociatedmetabolicandfunctionalchangesinhematopoieticstemcells
_version_	1718381924779556864

Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells

Ejemplares similares