Effectiveness of biosimilar drugs in the treatment of renal anemia: A case series

Introduction Patients with chronic kidney disease usually have anemia secondary to an erythropoietin deficit. The emergence of biosimilar drugs of erythropoiesis-stimulating agents ensures broader access to these treatments. Objective This study analyzes the effectiveness of an epoetin α biosim...

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Autores principales: Patricia Muñoz Ramos, Yohana Gil Giraldo, Vicente Álvarez Chiva
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Publicado: Medwave Estudios Limitada 2021
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Acceso en línea:https://doaj.org/article/a2ce73468f3043b2a5060f8e35081468
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spelling oai:doaj.org-article:a2ce73468f3043b2a5060f8e350814682021-11-26T15:43:55ZEffectiveness of biosimilar drugs in the treatment of renal anemia: A case series10.5867/medwave.2021.09.84740717-6384https://doaj.org/article/a2ce73468f3043b2a5060f8e350814682021-10-01T00:00:00Zhttps://www.medwave.cl/link.cgi/Medwave/Estudios/Investigacion/8474.acthttps://doaj.org/toc/0717-6384Introduction Patients with chronic kidney disease usually have anemia secondary to an erythropoietin deficit. The emergence of biosimilar drugs of erythropoiesis-stimulating agents ensures broader access to these treatments. Objective This study analyzes the effectiveness of an epoetin α biosimilar drug in chronic kidney disease patients with anemia. Methods This observational retrospective study enrolled 111 consecutive outpatients with chronic kidney disease and anemia and criteria for using erythropoiesis-stimulating agents. We collected baseline epidemiological and comorbidity data, as well as hematological and renal function infor-mation. We analyzed the effectiveness of the biosimilar agent in naïve patients and those who already had other erythropoiesis-stimulating agents. Results The 111 included patients had a mean age of 83 ± 8 years, and 54% were males. We found that patients who previously received erythropoiesis-stimulating agents, maintained hemoglobin values at two months of treatment with the biosimilar, while the naïve group significantly raised their hemoglobin values (P < 0.001). Renal function remained stable within the whole sample. The cost of using erythropoiesis-stimulating agents was reduced by a mean of 82 ± 17% with the biosimilar drug. Conclusion Using a biosimilar of epoetin α is effective in patients with chronic kidney disease and anemia and significantly reduces costs.Patricia Muñoz RamosYohana Gil GiraldoVicente Álvarez ChivaMedwave Estudios Limitadaarticleanemiabiosimilarchronic kidney diseaseerythropoietin stimulating agentsMedicineRMedicine (General)R5-920ENESMedwave, Vol 21, Iss 09, Pp e8474-e8474 (2021)
institution DOAJ
collection DOAJ
language EN
ES
topic anemia
biosimilar
chronic kidney disease
erythropoietin stimulating agents
Medicine
R
Medicine (General)
R5-920
spellingShingle anemia
biosimilar
chronic kidney disease
erythropoietin stimulating agents
Medicine
R
Medicine (General)
R5-920
Patricia Muñoz Ramos
Yohana Gil Giraldo
Vicente Álvarez Chiva
Effectiveness of biosimilar drugs in the treatment of renal anemia: A case series
description Introduction Patients with chronic kidney disease usually have anemia secondary to an erythropoietin deficit. The emergence of biosimilar drugs of erythropoiesis-stimulating agents ensures broader access to these treatments. Objective This study analyzes the effectiveness of an epoetin α biosimilar drug in chronic kidney disease patients with anemia. Methods This observational retrospective study enrolled 111 consecutive outpatients with chronic kidney disease and anemia and criteria for using erythropoiesis-stimulating agents. We collected baseline epidemiological and comorbidity data, as well as hematological and renal function infor-mation. We analyzed the effectiveness of the biosimilar agent in naïve patients and those who already had other erythropoiesis-stimulating agents. Results The 111 included patients had a mean age of 83 ± 8 years, and 54% were males. We found that patients who previously received erythropoiesis-stimulating agents, maintained hemoglobin values at two months of treatment with the biosimilar, while the naïve group significantly raised their hemoglobin values (P < 0.001). Renal function remained stable within the whole sample. The cost of using erythropoiesis-stimulating agents was reduced by a mean of 82 ± 17% with the biosimilar drug. Conclusion Using a biosimilar of epoetin α is effective in patients with chronic kidney disease and anemia and significantly reduces costs.
format article
author Patricia Muñoz Ramos
Yohana Gil Giraldo
Vicente Álvarez Chiva
author_facet Patricia Muñoz Ramos
Yohana Gil Giraldo
Vicente Álvarez Chiva
author_sort Patricia Muñoz Ramos
title Effectiveness of biosimilar drugs in the treatment of renal anemia: A case series
title_short Effectiveness of biosimilar drugs in the treatment of renal anemia: A case series
title_full Effectiveness of biosimilar drugs in the treatment of renal anemia: A case series
title_fullStr Effectiveness of biosimilar drugs in the treatment of renal anemia: A case series
title_full_unstemmed Effectiveness of biosimilar drugs in the treatment of renal anemia: A case series
title_sort effectiveness of biosimilar drugs in the treatment of renal anemia: a case series
publisher Medwave Estudios Limitada
publishDate 2021
url https://doaj.org/article/a2ce73468f3043b2a5060f8e35081468
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