FEATURES OF CYTOKINE BALANCE AND IMMUMOGLOBULIN E CONCENTRATIONS IN THE PATIENTS WITH CHRONIC NEPHRITIS DEPENDING ON TREATMENT OUTCOMES

The paper presents comparative data concerning immunoglobulin E balance, as well as IL-4 and IFNγ amounts, in the patients with chronic nephritis with a favorable outcome vs. therapy failure after a standardized treatment. Results of treatment applied were evaluated by expert conclusions of the doct...

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Autores principales:	N. A. Fedicheva, A. S. Bagdasarjan, R. A. Khanferian, L. V. Gorbov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	chronic nephritis response to therapy allergic inflammation Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/a2d73c23160f407dae1174ef65aa954c
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spelling	oai:doaj.org-article:a2d73c23160f407dae1174ef65aa954c2021-11-18T08:03:38ZFEATURES OF CYTOKINE BALANCE AND IMMUMOGLOBULIN E CONCENTRATIONS IN THE PATIENTS WITH CHRONIC NEPHRITIS DEPENDING ON TREATMENT OUTCOMES1563-06252313-741X10.15789/1563-0625-2010-4-5-343-348https://doaj.org/article/a2d73c23160f407dae1174ef65aa954c2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/180https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe paper presents comparative data concerning immunoglobulin E balance, as well as IL-4 and IFNγ amounts, in the patients with chronic nephritis with a favorable outcome vs. therapy failure after a standardized treatment. Results of treatment applied were evaluated by expert conclusions of the doctors, according to analysis of clinical and laboratory data. It has been shown that initial levels of IL-4 prior to the beginning of therapy were increased in the patients with inadequate response to therapy, as compared to healthy persons. Moreover, the patients with inadequate response to the treatment exhibited an increase in IgE concentrations and altered cytokine balance, thus suggesting a differentiation shift from naive Th to Th2 type, accompanied by development of allergic inflammation.N. A. FedichevaA. S. BagdasarjanR. A. KhanferianL. V. GorbovSPb RAACIarticlechronic nephritisresponse to therapyallergic inflammationImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 4-5, Pp 343-348 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	chronic nephritis response to therapy allergic inflammation Immunologic diseases. Allergy RC581-607
spellingShingle	chronic nephritis response to therapy allergic inflammation Immunologic diseases. Allergy RC581-607 N. A. Fedicheva A. S. Bagdasarjan R. A. Khanferian L. V. Gorbov FEATURES OF CYTOKINE BALANCE AND IMMUMOGLOBULIN E CONCENTRATIONS IN THE PATIENTS WITH CHRONIC NEPHRITIS DEPENDING ON TREATMENT OUTCOMES
description	The paper presents comparative data concerning immunoglobulin E balance, as well as IL-4 and IFNγ amounts, in the patients with chronic nephritis with a favorable outcome vs. therapy failure after a standardized treatment. Results of treatment applied were evaluated by expert conclusions of the doctors, according to analysis of clinical and laboratory data. It has been shown that initial levels of IL-4 prior to the beginning of therapy were increased in the patients with inadequate response to therapy, as compared to healthy persons. Moreover, the patients with inadequate response to the treatment exhibited an increase in IgE concentrations and altered cytokine balance, thus suggesting a differentiation shift from naive Th to Th2 type, accompanied by development of allergic inflammation.
format	article
author	N. A. Fedicheva A. S. Bagdasarjan R. A. Khanferian L. V. Gorbov
author_facet	N. A. Fedicheva A. S. Bagdasarjan R. A. Khanferian L. V. Gorbov
author_sort	N. A. Fedicheva
title	FEATURES OF CYTOKINE BALANCE AND IMMUMOGLOBULIN E CONCENTRATIONS IN THE PATIENTS WITH CHRONIC NEPHRITIS DEPENDING ON TREATMENT OUTCOMES
title_short	FEATURES OF CYTOKINE BALANCE AND IMMUMOGLOBULIN E CONCENTRATIONS IN THE PATIENTS WITH CHRONIC NEPHRITIS DEPENDING ON TREATMENT OUTCOMES
title_full	FEATURES OF CYTOKINE BALANCE AND IMMUMOGLOBULIN E CONCENTRATIONS IN THE PATIENTS WITH CHRONIC NEPHRITIS DEPENDING ON TREATMENT OUTCOMES
title_fullStr	FEATURES OF CYTOKINE BALANCE AND IMMUMOGLOBULIN E CONCENTRATIONS IN THE PATIENTS WITH CHRONIC NEPHRITIS DEPENDING ON TREATMENT OUTCOMES
title_full_unstemmed	FEATURES OF CYTOKINE BALANCE AND IMMUMOGLOBULIN E CONCENTRATIONS IN THE PATIENTS WITH CHRONIC NEPHRITIS DEPENDING ON TREATMENT OUTCOMES
title_sort	features of cytokine balance and immumoglobulin e concentrations in the patients with chronic nephritis depending on treatment outcomes
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/a2d73c23160f407dae1174ef65aa954c
work_keys_str_mv	AT nafedicheva featuresofcytokinebalanceandimmumoglobulineconcentrationsinthepatientswithchronicnephritisdependingontreatmentoutcomes AT asbagdasarjan featuresofcytokinebalanceandimmumoglobulineconcentrationsinthepatientswithchronicnephritisdependingontreatmentoutcomes AT rakhanferian featuresofcytokinebalanceandimmumoglobulineconcentrationsinthepatientswithchronicnephritisdependingontreatmentoutcomes AT lvgorbov featuresofcytokinebalanceandimmumoglobulineconcentrationsinthepatientswithchronicnephritisdependingontreatmentoutcomes
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FEATURES OF CYTOKINE BALANCE AND IMMUMOGLOBULIN E CONCENTRATIONS IN THE PATIENTS WITH CHRONIC NEPHRITIS DEPENDING ON TREATMENT OUTCOMES

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