Cortical dynamics during cell motility are regulated by CRL3KLHL21 E3 ubiquitin ligase

Cortical dynamics during cell motility are regulated by CRL3KLHL21 E3 ubiquitin ligase

Although focal adhesions (FAs) and microtubules (MTs) are known to associate, the underlying regulation of this dynamic interaction is not understood. Here the authors discover that the CRL3KLHL21E3 ubiquitin ligase localises to FAs and ubiquitinates the MT plus-tip binding protein EB1, thereby prom...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Thibault Courtheoux, Radoslav I. Enchev, Fabienne Lampert, Juan Gerez, Jochen Beck, Paola Picotti, Izabela Sumara, Matthias Peter
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/a2d821d0bb89479f8ec2492017573334
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:a2d821d0bb89479f8ec2492017573334
record_format dspace
spelling oai:doaj.org-article:a2d821d0bb89479f8ec24920175733342021-12-02T16:49:26ZCortical dynamics during cell motility are regulated by CRL3KLHL21 E3 ubiquitin ligase10.1038/ncomms128102041-1723https://doaj.org/article/a2d821d0bb89479f8ec24920175733342016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12810https://doaj.org/toc/2041-1723Although focal adhesions (FAs) and microtubules (MTs) are known to associate, the underlying regulation of this dynamic interaction is not understood. Here the authors discover that the CRL3KLHL21E3 ubiquitin ligase localises to FAs and ubiquitinates the MT plus-tip binding protein EB1, thereby promoting MT and FA dynamics and cell migration.Thibault CourtheouxRadoslav I. EnchevFabienne LampertJuan GerezJochen BeckPaola PicottiIzabela SumaraMatthias PeterNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Thibault Courtheoux
Radoslav I. Enchev
Fabienne Lampert
Juan Gerez
Jochen Beck
Paola Picotti
Izabela Sumara
Matthias Peter
Cortical dynamics during cell motility are regulated by CRL3KLHL21 E3 ubiquitin ligase
description Although focal adhesions (FAs) and microtubules (MTs) are known to associate, the underlying regulation of this dynamic interaction is not understood. Here the authors discover that the CRL3KLHL21E3 ubiquitin ligase localises to FAs and ubiquitinates the MT plus-tip binding protein EB1, thereby promoting MT and FA dynamics and cell migration.
format article
author Thibault Courtheoux
Radoslav I. Enchev
Fabienne Lampert
Juan Gerez
Jochen Beck
Paola Picotti
Izabela Sumara
Matthias Peter
author_facet Thibault Courtheoux
Radoslav I. Enchev
Fabienne Lampert
Juan Gerez
Jochen Beck
Paola Picotti
Izabela Sumara
Matthias Peter
author_sort Thibault Courtheoux
title Cortical dynamics during cell motility are regulated by CRL3KLHL21 E3 ubiquitin ligase
title_short Cortical dynamics during cell motility are regulated by CRL3KLHL21 E3 ubiquitin ligase
title_full Cortical dynamics during cell motility are regulated by CRL3KLHL21 E3 ubiquitin ligase
title_fullStr Cortical dynamics during cell motility are regulated by CRL3KLHL21 E3 ubiquitin ligase
title_full_unstemmed Cortical dynamics during cell motility are regulated by CRL3KLHL21 E3 ubiquitin ligase
title_sort cortical dynamics during cell motility are regulated by crl3klhl21 e3 ubiquitin ligase
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/a2d821d0bb89479f8ec2492017573334
work_keys_str_mv AT thibaultcourtheoux corticaldynamicsduringcellmotilityareregulatedbycrl3klhl21e3ubiquitinligase
AT radoslavienchev corticaldynamicsduringcellmotilityareregulatedbycrl3klhl21e3ubiquitinligase
AT fabiennelampert corticaldynamicsduringcellmotilityareregulatedbycrl3klhl21e3ubiquitinligase
AT juangerez corticaldynamicsduringcellmotilityareregulatedbycrl3klhl21e3ubiquitinligase
AT jochenbeck corticaldynamicsduringcellmotilityareregulatedbycrl3klhl21e3ubiquitinligase
AT paolapicotti corticaldynamicsduringcellmotilityareregulatedbycrl3klhl21e3ubiquitinligase
AT izabelasumara corticaldynamicsduringcellmotilityareregulatedbycrl3klhl21e3ubiquitinligase
AT matthiaspeter corticaldynamicsduringcellmotilityareregulatedbycrl3klhl21e3ubiquitinligase
_version_ 1718383352537415680

Ejemplares similares