Cortical dynamics during cell motility are regulated by CRL3KLHL21 E3 ubiquitin ligase

Cortical dynamics during cell motility are regulated by CRL3KLHL21 E3 ubiquitin ligase

Although focal adhesions (FAs) and microtubules (MTs) are known to associate, the underlying regulation of this dynamic interaction is not understood. Here the authors discover that the CRL3KLHL21E3 ubiquitin ligase localises to FAs and ubiquitinates the MT plus-tip binding protein EB1, thereby prom...

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Autores principales: Thibault Courtheoux, Radoslav I. Enchev, Fabienne Lampert, Juan Gerez, Jochen Beck, Paola Picotti, Izabela Sumara, Matthias Peter
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/a2d821d0bb89479f8ec2492017573334
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