Loss of p53 suppresses replication stress-induced DNA damage in ATRX-deficient neuroblastoma
Abstract Genetic aberrations are present in the ATRX gene in older high-risk neuroblastoma (NB) patients with very poor clinical outcomes. Its loss-of-function (LoF) facilitates the alternative lengthening of telomeres (ALT) pathway in tumor cells and is strongly linked to replication stress (RS) an...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
Nature Publishing Group
2021
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| Subjects: | |
| Online Access: | https://doaj.org/article/a2daa5a4a53642579e6bb90d160a40c5 |
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