Mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis

Tumorigenesis is a complex process driven by numerous risk factors. Here, genomic analysis of liver cancer reveals the evolution of mutational signatures during tumor development, highlighting mutational and structural signatures linked to environmental exposures and endogenous cellular processes.

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Autores principales:	Eric Letouzé, Jayendra Shinde, Victor Renault, Gabrielle Couchy, Jean-Frédéric Blanc, Emmanuel Tubacher, Quentin Bayard, Delphine Bacq, Vincent Meyer, Jérémy Semhoun, Paulette Bioulac-Sage, Sophie Prévôt, Daniel Azoulay, Valérie Paradis, Sandrine Imbeaud, Jean-François Deleuze, Jessica Zucman-Rossi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a2db6282c9e94e1b953a8aca7a20d3f7
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spelling	oai:doaj.org-article:a2db6282c9e94e1b953a8aca7a20d3f72021-12-02T17:06:18ZMutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis10.1038/s41467-017-01358-x2041-1723https://doaj.org/article/a2db6282c9e94e1b953a8aca7a20d3f72017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01358-xhttps://doaj.org/toc/2041-1723Tumorigenesis is a complex process driven by numerous risk factors. Here, genomic analysis of liver cancer reveals the evolution of mutational signatures during tumor development, highlighting mutational and structural signatures linked to environmental exposures and endogenous cellular processes.Eric LetouzéJayendra ShindeVictor RenaultGabrielle CouchyJean-Frédéric BlancEmmanuel TubacherQuentin BayardDelphine BacqVincent MeyerJérémy SemhounPaulette Bioulac-SageSophie PrévôtDaniel AzoulayValérie ParadisSandrine ImbeaudJean-François DeleuzeJessica Zucman-RossiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eric Letouzé Jayendra Shinde Victor Renault Gabrielle Couchy Jean-Frédéric Blanc Emmanuel Tubacher Quentin Bayard Delphine Bacq Vincent Meyer Jérémy Semhoun Paulette Bioulac-Sage Sophie Prévôt Daniel Azoulay Valérie Paradis Sandrine Imbeaud Jean-François Deleuze Jessica Zucman-Rossi Mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis
description	Tumorigenesis is a complex process driven by numerous risk factors. Here, genomic analysis of liver cancer reveals the evolution of mutational signatures during tumor development, highlighting mutational and structural signatures linked to environmental exposures and endogenous cellular processes.
format	article
author	Eric Letouzé Jayendra Shinde Victor Renault Gabrielle Couchy Jean-Frédéric Blanc Emmanuel Tubacher Quentin Bayard Delphine Bacq Vincent Meyer Jérémy Semhoun Paulette Bioulac-Sage Sophie Prévôt Daniel Azoulay Valérie Paradis Sandrine Imbeaud Jean-François Deleuze Jessica Zucman-Rossi
author_facet	Eric Letouzé Jayendra Shinde Victor Renault Gabrielle Couchy Jean-Frédéric Blanc Emmanuel Tubacher Quentin Bayard Delphine Bacq Vincent Meyer Jérémy Semhoun Paulette Bioulac-Sage Sophie Prévôt Daniel Azoulay Valérie Paradis Sandrine Imbeaud Jean-François Deleuze Jessica Zucman-Rossi
author_sort	Eric Letouzé
title	Mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis
title_short	Mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis
title_full	Mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis
title_fullStr	Mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis
title_full_unstemmed	Mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis
title_sort	mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a2db6282c9e94e1b953a8aca7a20d3f7
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Mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis

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