Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis

BCL6 corepressor (BCOR) is recurrently mutated in acute myeloid leukaemia and myelodysplastic syndrome. Here, the authors use mouse models to show the mechanism of how inactivation of BCOR in haematopoietic stem cells contributes to the development of leukaemia.

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Auteurs principaux:	Madison J. Kelly, Joan So, Amy J. Rogers, Gareth Gregory, Jason Li, Magnus Zethoven, Micah D. Gearhart, Vivian J. Bardwell, Ricky W. Johnstone, Stephin J. Vervoort, Lev M. Kats
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/a2e6698ad2f4471982b9c6935cb918b2
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spelling	oai:doaj.org-article:a2e6698ad2f4471982b9c6935cb918b22021-12-02T14:38:42ZBcor loss perturbs myeloid differentiation and promotes leukaemogenesis10.1038/s41467-019-09250-62041-1723https://doaj.org/article/a2e6698ad2f4471982b9c6935cb918b22019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09250-6https://doaj.org/toc/2041-1723BCL6 corepressor (BCOR) is recurrently mutated in acute myeloid leukaemia and myelodysplastic syndrome. Here, the authors use mouse models to show the mechanism of how inactivation of BCOR in haematopoietic stem cells contributes to the development of leukaemia.Madison J. KellyJoan SoAmy J. RogersGareth GregoryJason LiMagnus ZethovenMicah D. GearhartVivian J. BardwellRicky W. JohnstoneStephin J. VervoortLev M. KatsNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Madison J. Kelly Joan So Amy J. Rogers Gareth Gregory Jason Li Magnus Zethoven Micah D. Gearhart Vivian J. Bardwell Ricky W. Johnstone Stephin J. Vervoort Lev M. Kats Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis
description	BCL6 corepressor (BCOR) is recurrently mutated in acute myeloid leukaemia and myelodysplastic syndrome. Here, the authors use mouse models to show the mechanism of how inactivation of BCOR in haematopoietic stem cells contributes to the development of leukaemia.
format	article
author	Madison J. Kelly Joan So Amy J. Rogers Gareth Gregory Jason Li Magnus Zethoven Micah D. Gearhart Vivian J. Bardwell Ricky W. Johnstone Stephin J. Vervoort Lev M. Kats
author_facet	Madison J. Kelly Joan So Amy J. Rogers Gareth Gregory Jason Li Magnus Zethoven Micah D. Gearhart Vivian J. Bardwell Ricky W. Johnstone Stephin J. Vervoort Lev M. Kats
author_sort	Madison J. Kelly
title	Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis
title_short	Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis
title_full	Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis
title_fullStr	Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis
title_full_unstemmed	Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis
title_sort	bcor loss perturbs myeloid differentiation and promotes leukaemogenesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a2e6698ad2f4471982b9c6935cb918b2
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Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis

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