Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis

Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis

BCL6 corepressor (BCOR) is recurrently mutated in acute myeloid leukaemia and myelodysplastic syndrome. Here, the authors use mouse models to show the mechanism of how inactivation of BCOR in haematopoietic stem cells contributes to the development of leukaemia.

Saved in:
Bibliographic Details
Main Authors: Madison J. Kelly, Joan So, Amy J. Rogers, Gareth Gregory, Jason Li, Magnus Zethoven, Micah D. Gearhart, Vivian J. Bardwell, Ricky W. Johnstone, Stephin J. Vervoort, Lev M. Kats
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Science
Q
Online Access:https://doaj.org/article/a2e6698ad2f4471982b9c6935cb918b2
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/a2e6698ad2f4471982b9c6935cb918b2

Similar Items