Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor

The hypoxic microenvironment in solid tumors limits the efficacy of photodynamic therapy (PDT) since oxygen is necessary to produce high cytotoxic singlet oxygen species. Here, the authors develop an improved self-assembled single-atom nanozyme which allows oxygen generation to enhance PDT efficacy.

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Autores principales: Dongdong Wang, Huihui Wu, Soo Zeng Fiona Phua, Guangbao Yang, Wei Qi Lim, Long Gu, Cheng Qian, Haibao Wang, Zhen Guo, Hongzhong Chen, Yanli Zhao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/a2ef257ac4894317964ca7d79d63039f
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Sumario:The hypoxic microenvironment in solid tumors limits the efficacy of photodynamic therapy (PDT) since oxygen is necessary to produce high cytotoxic singlet oxygen species. Here, the authors develop an improved self-assembled single-atom nanozyme which allows oxygen generation to enhance PDT efficacy.