THE INOTROPIC AND CHRONOTROPIC EFFECTS OF AQUEOUS ETHANOLIC EXTRACT FROM TEUCRIUM POLIUM L. ON GUINEA PIG ISOLATED HEART

BACKGROUND AND OBJECTIVE: Teucrium polium L. (TP) is widely used in traditional medicine. There are some reports on antidiabetic, antihyperlipidemic and antibacterial effects of TP. The aim of this study was to investigate the inotropic and chronotropic effects of aqueousethanolic extract from TP on...

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Autores principales:	S Niazmand, M Erfanian Ahmadpour, M Mousavian, Z Saberi
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2008
Materias:	teucrium polium l. isolated heart heart rate heart contractility guinea pig l-type calcium channel Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a2f0594a9d3d4279a222075024cea8d7
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spelling	oai:doaj.org-article:a2f0594a9d3d4279a222075024cea8d72021-11-10T09:07:19ZTHE INOTROPIC AND CHRONOTROPIC EFFECTS OF AQUEOUS ETHANOLIC EXTRACT FROM TEUCRIUM POLIUM L. ON GUINEA PIG ISOLATED HEART1561-41072251-7170https://doaj.org/article/a2f0594a9d3d4279a222075024cea8d72008-04-01T00:00:00Zhttp://jbums.org/article-1-2477-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Teucrium polium L. (TP) is widely used in traditional medicine. There are some reports on antidiabetic, antihyperlipidemic and antibacterial effects of TP. The aim of this study was to investigate the inotropic and chronotropic effects of aqueousethanolic extract from TP on guinea pig isolated heart. METHODS: In this experimental study, 24 Dunkin Hartley guinea pigs weighted 350-450 g were used. The animals randomly divided into three groups (8 in each group): group 1 which the heart perfused by Krebs solution, group 2 which the heart perfused by Krebs calcium free solution and group 3 which the heart perfused by Krebs+diltiazem solution. The heart isolated after the aorta cannulated and connected to Langendorff setup. Three concentration of aqueousethanolic extarct from TP were infused to the heart for 1 minute. The heart rate and contractility recorded by computer. FINDINGS: The TP extract increased significantly the heart rate (HR) and contractility in all three groups. This effect was not concentration dependent. Comparing mean percent changes of HR and contractility between three groups showed a significant difference between groups 1 and 3 and also between groups 2 and 3, but the difference between groups 1 and 2 was not significant. CONCLUSION: The aqueous ethanolic extract from TP has a positive chronotropic and inotropic effects on guinea pig isolated heart. The extract has an agonistic effect on L-type calcium channels.S NiazmandM Erfanian Ahmadpour,M MousavianZ SaberiBabol University of Medical Sciencesarticleteucrium polium l.isolated heartheart rateheart contractilityguinea pigl-type calcium channelMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 10, Iss 1, Pp 7-13 (2008)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	teucrium polium l. isolated heart heart rate heart contractility guinea pig l-type calcium channel Medicine R Medicine (General) R5-920
spellingShingle	teucrium polium l. isolated heart heart rate heart contractility guinea pig l-type calcium channel Medicine R Medicine (General) R5-920 S Niazmand M Erfanian Ahmadpour, M Mousavian Z Saberi THE INOTROPIC AND CHRONOTROPIC EFFECTS OF AQUEOUS ETHANOLIC EXTRACT FROM TEUCRIUM POLIUM L. ON GUINEA PIG ISOLATED HEART
description	BACKGROUND AND OBJECTIVE: Teucrium polium L. (TP) is widely used in traditional medicine. There are some reports on antidiabetic, antihyperlipidemic and antibacterial effects of TP. The aim of this study was to investigate the inotropic and chronotropic effects of aqueousethanolic extract from TP on guinea pig isolated heart. METHODS: In this experimental study, 24 Dunkin Hartley guinea pigs weighted 350-450 g were used. The animals randomly divided into three groups (8 in each group): group 1 which the heart perfused by Krebs solution, group 2 which the heart perfused by Krebs calcium free solution and group 3 which the heart perfused by Krebs+diltiazem solution. The heart isolated after the aorta cannulated and connected to Langendorff setup. Three concentration of aqueousethanolic extarct from TP were infused to the heart for 1 minute. The heart rate and contractility recorded by computer. FINDINGS: The TP extract increased significantly the heart rate (HR) and contractility in all three groups. This effect was not concentration dependent. Comparing mean percent changes of HR and contractility between three groups showed a significant difference between groups 1 and 3 and also between groups 2 and 3, but the difference between groups 1 and 2 was not significant. CONCLUSION: The aqueous ethanolic extract from TP has a positive chronotropic and inotropic effects on guinea pig isolated heart. The extract has an agonistic effect on L-type calcium channels.
format	article
author	S Niazmand M Erfanian Ahmadpour, M Mousavian Z Saberi
author_facet	S Niazmand M Erfanian Ahmadpour, M Mousavian Z Saberi
author_sort	S Niazmand
title	THE INOTROPIC AND CHRONOTROPIC EFFECTS OF AQUEOUS ETHANOLIC EXTRACT FROM TEUCRIUM POLIUM L. ON GUINEA PIG ISOLATED HEART
title_short	THE INOTROPIC AND CHRONOTROPIC EFFECTS OF AQUEOUS ETHANOLIC EXTRACT FROM TEUCRIUM POLIUM L. ON GUINEA PIG ISOLATED HEART
title_full	THE INOTROPIC AND CHRONOTROPIC EFFECTS OF AQUEOUS ETHANOLIC EXTRACT FROM TEUCRIUM POLIUM L. ON GUINEA PIG ISOLATED HEART
title_fullStr	THE INOTROPIC AND CHRONOTROPIC EFFECTS OF AQUEOUS ETHANOLIC EXTRACT FROM TEUCRIUM POLIUM L. ON GUINEA PIG ISOLATED HEART
title_full_unstemmed	THE INOTROPIC AND CHRONOTROPIC EFFECTS OF AQUEOUS ETHANOLIC EXTRACT FROM TEUCRIUM POLIUM L. ON GUINEA PIG ISOLATED HEART
title_sort	inotropic and chronotropic effects of aqueous ethanolic extract from teucrium polium l. on guinea pig isolated heart
publisher	Babol University of Medical Sciences
publishDate	2008
url	https://doaj.org/article/a2f0594a9d3d4279a222075024cea8d7
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THE INOTROPIC AND CHRONOTROPIC EFFECTS OF AQUEOUS ETHANOLIC EXTRACT FROM TEUCRIUM POLIUM L. ON GUINEA PIG ISOLATED HEART

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