Subthalamic stimulation breaks the balance between distal and axial signs in Parkinson’s disease

Abstract In Parkinson’s disease (PD), the effects of both Ldopa and subthalamic deep brain stimulation (STN-DBS) are known to change cost-valuation. However, this was mostly studied through reward-effort task involving distal movements, while axial effort, less responsive to treatments, have been ba...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Cyril Atkinson-Clement, Émilie Cavazzini, Alexandre Zénon, Thierry Legou, Tatiana Witjas, Frédérique Fluchère, Jean-Philippe Azulay, Christelle Baunez, Serge Pinto, Alexandre Eusebio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a2f1c06bc7474fe488d0bfda83b466cc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a2f1c06bc7474fe488d0bfda83b466cc
record_format	dspace
spelling	oai:doaj.org-article:a2f1c06bc7474fe488d0bfda83b466cc2021-11-14T12:21:10ZSubthalamic stimulation breaks the balance between distal and axial signs in Parkinson’s disease10.1038/s41598-021-01386-02045-2322https://doaj.org/article/a2f1c06bc7474fe488d0bfda83b466cc2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01386-0https://doaj.org/toc/2045-2322Abstract In Parkinson’s disease (PD), the effects of both Ldopa and subthalamic deep brain stimulation (STN-DBS) are known to change cost-valuation. However, this was mostly studied through reward-effort task involving distal movements, while axial effort, less responsive to treatments, have been barely studied. Thus, our objective was to compare the influence of both Ldopa and STN-DBS on cost-valuation between two efforts modalities: vowel production (as an example of axial movement) and hand squeezing (as an example of distal movement). Twelve PD patients were recruited to participate in this study. The task consisted in deciding whether to accept or reject trials based on a reward-effort trade-off. Participants performed two blocks with hand squeezing, and two with vowel production, in the four treatment conditions (Ldopa On/Off; STN-DBS On/Off). We found that STN-DBS changed the ratio difference between hand and phonation efforts. Vowel production effort was estimated easier to perform with STN-DBS alone, and harder when associated with Ldopa. The difference between hand and phonation efforts was correlated with quality of life in Off/Off and On Ldopa alone conditions, and with impulsive assessment On STN-DBS alone. We highlighted that STN-DBS could introduce an imbalance between the actual motor impairments and their subjective costs. With this finding, we also suggest paying particular attention to the different treatment effects that should be expected for axial and distal movement dysfunctions.Cyril Atkinson-ClementÉmilie CavazziniAlexandre ZénonThierry LegouTatiana WitjasFrédérique FluchèreJean-Philippe AzulayChristelle BaunezSerge PintoAlexandre EusebioNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cyril Atkinson-Clement Émilie Cavazzini Alexandre Zénon Thierry Legou Tatiana Witjas Frédérique Fluchère Jean-Philippe Azulay Christelle Baunez Serge Pinto Alexandre Eusebio Subthalamic stimulation breaks the balance between distal and axial signs in Parkinson’s disease
description	Abstract In Parkinson’s disease (PD), the effects of both Ldopa and subthalamic deep brain stimulation (STN-DBS) are known to change cost-valuation. However, this was mostly studied through reward-effort task involving distal movements, while axial effort, less responsive to treatments, have been barely studied. Thus, our objective was to compare the influence of both Ldopa and STN-DBS on cost-valuation between two efforts modalities: vowel production (as an example of axial movement) and hand squeezing (as an example of distal movement). Twelve PD patients were recruited to participate in this study. The task consisted in deciding whether to accept or reject trials based on a reward-effort trade-off. Participants performed two blocks with hand squeezing, and two with vowel production, in the four treatment conditions (Ldopa On/Off; STN-DBS On/Off). We found that STN-DBS changed the ratio difference between hand and phonation efforts. Vowel production effort was estimated easier to perform with STN-DBS alone, and harder when associated with Ldopa. The difference between hand and phonation efforts was correlated with quality of life in Off/Off and On Ldopa alone conditions, and with impulsive assessment On STN-DBS alone. We highlighted that STN-DBS could introduce an imbalance between the actual motor impairments and their subjective costs. With this finding, we also suggest paying particular attention to the different treatment effects that should be expected for axial and distal movement dysfunctions.
format	article
author	Cyril Atkinson-Clement Émilie Cavazzini Alexandre Zénon Thierry Legou Tatiana Witjas Frédérique Fluchère Jean-Philippe Azulay Christelle Baunez Serge Pinto Alexandre Eusebio
author_facet	Cyril Atkinson-Clement Émilie Cavazzini Alexandre Zénon Thierry Legou Tatiana Witjas Frédérique Fluchère Jean-Philippe Azulay Christelle Baunez Serge Pinto Alexandre Eusebio
author_sort	Cyril Atkinson-Clement
title	Subthalamic stimulation breaks the balance between distal and axial signs in Parkinson’s disease
title_short	Subthalamic stimulation breaks the balance between distal and axial signs in Parkinson’s disease
title_full	Subthalamic stimulation breaks the balance between distal and axial signs in Parkinson’s disease
title_fullStr	Subthalamic stimulation breaks the balance between distal and axial signs in Parkinson’s disease
title_full_unstemmed	Subthalamic stimulation breaks the balance between distal and axial signs in Parkinson’s disease
title_sort	subthalamic stimulation breaks the balance between distal and axial signs in parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a2f1c06bc7474fe488d0bfda83b466cc
work_keys_str_mv	AT cyrilatkinsonclement subthalamicstimulationbreaksthebalancebetweendistalandaxialsignsinparkinsonsdisease AT emiliecavazzini subthalamicstimulationbreaksthebalancebetweendistalandaxialsignsinparkinsonsdisease AT alexandrezenon subthalamicstimulationbreaksthebalancebetweendistalandaxialsignsinparkinsonsdisease AT thierrylegou subthalamicstimulationbreaksthebalancebetweendistalandaxialsignsinparkinsonsdisease AT tatianawitjas subthalamicstimulationbreaksthebalancebetweendistalandaxialsignsinparkinsonsdisease AT frederiquefluchere subthalamicstimulationbreaksthebalancebetweendistalandaxialsignsinparkinsonsdisease AT jeanphilippeazulay subthalamicstimulationbreaksthebalancebetweendistalandaxialsignsinparkinsonsdisease AT christellebaunez subthalamicstimulationbreaksthebalancebetweendistalandaxialsignsinparkinsonsdisease AT sergepinto subthalamicstimulationbreaksthebalancebetweendistalandaxialsignsinparkinsonsdisease AT alexandreeusebio subthalamicstimulationbreaksthebalancebetweendistalandaxialsignsinparkinsonsdisease
_version_	1718429247301746688

Subthalamic stimulation breaks the balance between distal and axial signs in Parkinson’s disease

Ejemplares similares