Pneumonic-type lung adenocarcinoma with different ranges exhibiting different clinical, imaging, and pathological characteristics

Abstract Background Pneumonic-type lung adenocarcinoma (PLADC) with different ranges might exhibit different imaging and clinicopathological features. This study divided PLADC into localized PLADC (L-PLADC) and diffuse PLADC (D-PLADC) based on imaging and aimed to clarify the differences in clinical...

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Autores principales:	Ji-wen Huo, Xing-tao Huang, Xian Li, Jun-wei Gong, Tian-you Luo, Qi Li
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Pneumonic-type lung adenocarcinoma Tomography (X-ray computed) Epidermal growth factor receptor Medical physics. Medical radiology. Nuclear medicine R895-920
Acceso en línea:	https://doaj.org/article/a2f240fde08148ea87d46bdb6a258051
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spelling	oai:doaj.org-article:a2f240fde08148ea87d46bdb6a2580512021-11-21T12:07:05ZPneumonic-type lung adenocarcinoma with different ranges exhibiting different clinical, imaging, and pathological characteristics10.1186/s13244-021-01114-21869-4101https://doaj.org/article/a2f240fde08148ea87d46bdb6a2580512021-11-01T00:00:00Zhttps://doi.org/10.1186/s13244-021-01114-2https://doaj.org/toc/1869-4101Abstract Background Pneumonic-type lung adenocarcinoma (PLADC) with different ranges might exhibit different imaging and clinicopathological features. This study divided PLADC into localized PLADC (L-PLADC) and diffuse PLADC (D-PLADC) based on imaging and aimed to clarify the differences in clinical, imaging, and pathologic characteristics between the two new subtypes. Results The data of 131 patients with L-PLADC and 117 patients with D-PLADC who were pathologically confirmed and underwent chest computed tomography (CT) at our institute from December 2014 to December 2020 were retrospectively collected. Patients with L-PLADC were predominantly female, non-smokers, and without respiratory symptoms and elevated white blood cell count and C-reactive protein level, whereas those with D-PLADC were predominantly male, smokers, and had respiratory symptoms and elevated white blood cell count and C-reactive protein level (all p < 0.05). Pleural retraction was more common in L-PLADC, whereas interlobular fissure bulging, hypodense sign, air space, CT angiogram sign, coexisting nodules, pleural effusion, and lymphadenopathy were more frequent in D-PLADC (all p < 0.001). Among the 129 patients with surgically resected PLADC, the most common histological subtype of L-PLADC was acinar-predominant growth pattern (76.7%, 79/103), whereas that of D-PLADC was invasive mucinous adenocarcinoma (80.8%, 21/26). Among the 136 patients with EGFR mutation status, L-PLADC had a significantly higher EGFR mutation rate than D-PLADC (p < 0.001). Conclusions L-PLADC and D-PLADC have different clinical, imaging, and pathological characteristics. This new imaging-based classification may help improve our understanding of PLADC and develop personalized treatment plans, with concomitant implications for patient outcomes.Ji-wen HuoXing-tao HuangXian LiJun-wei GongTian-you LuoQi LiSpringerOpenarticlePneumonic-type lung adenocarcinomaTomography (X-ray computed)Epidermal growth factor receptorMedical physics. Medical radiology. Nuclear medicineR895-920ENInsights into Imaging, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pneumonic-type lung adenocarcinoma Tomography (X-ray computed) Epidermal growth factor receptor Medical physics. Medical radiology. Nuclear medicine R895-920
spellingShingle	Pneumonic-type lung adenocarcinoma Tomography (X-ray computed) Epidermal growth factor receptor Medical physics. Medical radiology. Nuclear medicine R895-920 Ji-wen Huo Xing-tao Huang Xian Li Jun-wei Gong Tian-you Luo Qi Li Pneumonic-type lung adenocarcinoma with different ranges exhibiting different clinical, imaging, and pathological characteristics
description	Abstract Background Pneumonic-type lung adenocarcinoma (PLADC) with different ranges might exhibit different imaging and clinicopathological features. This study divided PLADC into localized PLADC (L-PLADC) and diffuse PLADC (D-PLADC) based on imaging and aimed to clarify the differences in clinical, imaging, and pathologic characteristics between the two new subtypes. Results The data of 131 patients with L-PLADC and 117 patients with D-PLADC who were pathologically confirmed and underwent chest computed tomography (CT) at our institute from December 2014 to December 2020 were retrospectively collected. Patients with L-PLADC were predominantly female, non-smokers, and without respiratory symptoms and elevated white blood cell count and C-reactive protein level, whereas those with D-PLADC were predominantly male, smokers, and had respiratory symptoms and elevated white blood cell count and C-reactive protein level (all p < 0.05). Pleural retraction was more common in L-PLADC, whereas interlobular fissure bulging, hypodense sign, air space, CT angiogram sign, coexisting nodules, pleural effusion, and lymphadenopathy were more frequent in D-PLADC (all p < 0.001). Among the 129 patients with surgically resected PLADC, the most common histological subtype of L-PLADC was acinar-predominant growth pattern (76.7%, 79/103), whereas that of D-PLADC was invasive mucinous adenocarcinoma (80.8%, 21/26). Among the 136 patients with EGFR mutation status, L-PLADC had a significantly higher EGFR mutation rate than D-PLADC (p < 0.001). Conclusions L-PLADC and D-PLADC have different clinical, imaging, and pathological characteristics. This new imaging-based classification may help improve our understanding of PLADC and develop personalized treatment plans, with concomitant implications for patient outcomes.
format	article
author	Ji-wen Huo Xing-tao Huang Xian Li Jun-wei Gong Tian-you Luo Qi Li
author_facet	Ji-wen Huo Xing-tao Huang Xian Li Jun-wei Gong Tian-you Luo Qi Li
author_sort	Ji-wen Huo
title	Pneumonic-type lung adenocarcinoma with different ranges exhibiting different clinical, imaging, and pathological characteristics
title_short	Pneumonic-type lung adenocarcinoma with different ranges exhibiting different clinical, imaging, and pathological characteristics
title_full	Pneumonic-type lung adenocarcinoma with different ranges exhibiting different clinical, imaging, and pathological characteristics
title_fullStr	Pneumonic-type lung adenocarcinoma with different ranges exhibiting different clinical, imaging, and pathological characteristics
title_full_unstemmed	Pneumonic-type lung adenocarcinoma with different ranges exhibiting different clinical, imaging, and pathological characteristics
title_sort	pneumonic-type lung adenocarcinoma with different ranges exhibiting different clinical, imaging, and pathological characteristics
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/a2f240fde08148ea87d46bdb6a258051
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_version_	1718419203155820544

Pneumonic-type lung adenocarcinoma with different ranges exhibiting different clinical, imaging, and pathological characteristics

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