Experimental Chlamydia gallinacea infection in chickens does not protect against a subsequent experimental Chlamydia psittaci infection

Abstract Chlamydia psittaci was considered the predominant chlamydial species in poultry until Chlamydia gallinacea was discovered in 2009. C. psittaci is a zoonotic obligate intracellular bacterium reported in more than 465 bird species including poultry. In poultry, infections can result in asympt...

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Autores principales:	Marloes Heijne, Jeanet van der Goot, Herma Buys, Annemieke Dinkla, Hendrik Jan Roest, Lucien van Keulen, Ad Koets
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Chlamydia Cross immunity Cross protection Chickens Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/a2f4b6dc76274e31bb8b455ae3b880be
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spelling	oai:doaj.org-article:a2f4b6dc76274e31bb8b455ae3b880be2021-11-21T12:04:35ZExperimental Chlamydia gallinacea infection in chickens does not protect against a subsequent experimental Chlamydia psittaci infection10.1186/s13567-021-01011-y1297-9716https://doaj.org/article/a2f4b6dc76274e31bb8b455ae3b880be2021-11-01T00:00:00Zhttps://doi.org/10.1186/s13567-021-01011-yhttps://doaj.org/toc/1297-9716Abstract Chlamydia psittaci was considered the predominant chlamydial species in poultry until Chlamydia gallinacea was discovered in 2009. C. psittaci is a zoonotic obligate intracellular bacterium reported in more than 465 bird species including poultry. In poultry, infections can result in asymptomatic disease, but also in more severe systemic illness. The zoonotic potential of C. gallinacea has yet to be proven. Infections in poultry appear to be asymptomatic and in recent prevalence studies C. gallinacea was the main chlamydial species found in chickens. The high prevalence of C. gallinacea resulted in the question if an infection with C. gallinacea might protect against an infection with C. psittaci. To investigate possible cross protection, chickens were inoculated with C. gallinacea NL_G47 and subsequently inoculated with either a different strain of C. gallinacea (NL_F725) or C. psittaci. Chickens that had not been pre-inoculated with C. gallinacea NL_G47 were used as a C. gallinacea or C. psittaci infection control. In the groups that were inoculated with C. psittaci, no difference in pharyngeal or cloacal shedding, or in tissue dissemination was observed between the control group and the pre-inoculated group. In the groups inoculated with C. gallinacea NL_F725, shedding in cloacal swabs and tissues dissemination was lower in the group pre-inoculated with C. gallinacea NL_G47. These results indicate previous exposure to C. gallinacea does not protect against an infection with C. psittaci, but might protect against a new infection of C. gallinacea.Marloes HeijneJeanet van der GootHerma BuysAnnemieke DinklaHendrik Jan RoestLucien van KeulenAd KoetsBMCarticleChlamydiaCross immunityCross protectionChickensVeterinary medicineSF600-1100ENVeterinary Research, Vol 52, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chlamydia Cross immunity Cross protection Chickens Veterinary medicine SF600-1100
spellingShingle	Chlamydia Cross immunity Cross protection Chickens Veterinary medicine SF600-1100 Marloes Heijne Jeanet van der Goot Herma Buys Annemieke Dinkla Hendrik Jan Roest Lucien van Keulen Ad Koets Experimental Chlamydia gallinacea infection in chickens does not protect against a subsequent experimental Chlamydia psittaci infection
description	Abstract Chlamydia psittaci was considered the predominant chlamydial species in poultry until Chlamydia gallinacea was discovered in 2009. C. psittaci is a zoonotic obligate intracellular bacterium reported in more than 465 bird species including poultry. In poultry, infections can result in asymptomatic disease, but also in more severe systemic illness. The zoonotic potential of C. gallinacea has yet to be proven. Infections in poultry appear to be asymptomatic and in recent prevalence studies C. gallinacea was the main chlamydial species found in chickens. The high prevalence of C. gallinacea resulted in the question if an infection with C. gallinacea might protect against an infection with C. psittaci. To investigate possible cross protection, chickens were inoculated with C. gallinacea NL_G47 and subsequently inoculated with either a different strain of C. gallinacea (NL_F725) or C. psittaci. Chickens that had not been pre-inoculated with C. gallinacea NL_G47 were used as a C. gallinacea or C. psittaci infection control. In the groups that were inoculated with C. psittaci, no difference in pharyngeal or cloacal shedding, or in tissue dissemination was observed between the control group and the pre-inoculated group. In the groups inoculated with C. gallinacea NL_F725, shedding in cloacal swabs and tissues dissemination was lower in the group pre-inoculated with C. gallinacea NL_G47. These results indicate previous exposure to C. gallinacea does not protect against an infection with C. psittaci, but might protect against a new infection of C. gallinacea.
format	article
author	Marloes Heijne Jeanet van der Goot Herma Buys Annemieke Dinkla Hendrik Jan Roest Lucien van Keulen Ad Koets
author_facet	Marloes Heijne Jeanet van der Goot Herma Buys Annemieke Dinkla Hendrik Jan Roest Lucien van Keulen Ad Koets
author_sort	Marloes Heijne
title	Experimental Chlamydia gallinacea infection in chickens does not protect against a subsequent experimental Chlamydia psittaci infection
title_short	Experimental Chlamydia gallinacea infection in chickens does not protect against a subsequent experimental Chlamydia psittaci infection
title_full	Experimental Chlamydia gallinacea infection in chickens does not protect against a subsequent experimental Chlamydia psittaci infection
title_fullStr	Experimental Chlamydia gallinacea infection in chickens does not protect against a subsequent experimental Chlamydia psittaci infection
title_full_unstemmed	Experimental Chlamydia gallinacea infection in chickens does not protect against a subsequent experimental Chlamydia psittaci infection
title_sort	experimental chlamydia gallinacea infection in chickens does not protect against a subsequent experimental chlamydia psittaci infection
publisher	BMC
publishDate	2021
url	https://doaj.org/article/a2f4b6dc76274e31bb8b455ae3b880be
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Experimental Chlamydia gallinacea infection in chickens does not protect against a subsequent experimental Chlamydia psittaci infection

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