Reconstruction of the 1918 Influenza Virus: Unexpected Rewards from the Past

ABSTRACT The influenza pandemic of 1918–1919 killed approximately 50 million people. The unusually severe morbidity and mortality associated with the pandemic spurred physicians and scientists to isolate the etiologic agent, but the virus was not isolated in 1918. In 1996, it became possible to reco...

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Autores principales:	Jeffery K. Taubenberger, David Baltimore, Peter C. Doherty, Howard Markel, David M. Morens, Robert G. Webster, Ian A. Wilson
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2012
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/a2f5c05465ae4e928f2819aace84c8dd
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spelling	oai:doaj.org-article:a2f5c05465ae4e928f2819aace84c8dd2021-11-15T15:39:13ZReconstruction of the 1918 Influenza Virus: Unexpected Rewards from the Past10.1128/mBio.00201-122150-7511https://doaj.org/article/a2f5c05465ae4e928f2819aace84c8dd2012-11-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00201-12https://doaj.org/toc/2150-7511ABSTRACT The influenza pandemic of 1918–1919 killed approximately 50 million people. The unusually severe morbidity and mortality associated with the pandemic spurred physicians and scientists to isolate the etiologic agent, but the virus was not isolated in 1918. In 1996, it became possible to recover and sequence highly degraded fragments of influenza viral RNA retained in preserved tissues from several 1918 victims. These viral RNA sequences eventually permitted reconstruction of the complete 1918 virus, which has yielded, almost a century after the deaths of its victims, novel insights into influenza virus biology and pathogenesis and has provided important information about how to prevent and control future pandemics.Jeffery K. TaubenbergerDavid BaltimorePeter C. DohertyHoward MarkelDavid M. MorensRobert G. WebsterIan A. WilsonAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 3, Iss 5 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Jeffery K. Taubenberger David Baltimore Peter C. Doherty Howard Markel David M. Morens Robert G. Webster Ian A. Wilson Reconstruction of the 1918 Influenza Virus: Unexpected Rewards from the Past
description	ABSTRACT The influenza pandemic of 1918–1919 killed approximately 50 million people. The unusually severe morbidity and mortality associated with the pandemic spurred physicians and scientists to isolate the etiologic agent, but the virus was not isolated in 1918. In 1996, it became possible to recover and sequence highly degraded fragments of influenza viral RNA retained in preserved tissues from several 1918 victims. These viral RNA sequences eventually permitted reconstruction of the complete 1918 virus, which has yielded, almost a century after the deaths of its victims, novel insights into influenza virus biology and pathogenesis and has provided important information about how to prevent and control future pandemics.
format	article
author	Jeffery K. Taubenberger David Baltimore Peter C. Doherty Howard Markel David M. Morens Robert G. Webster Ian A. Wilson
author_facet	Jeffery K. Taubenberger David Baltimore Peter C. Doherty Howard Markel David M. Morens Robert G. Webster Ian A. Wilson
author_sort	Jeffery K. Taubenberger
title	Reconstruction of the 1918 Influenza Virus: Unexpected Rewards from the Past
title_short	Reconstruction of the 1918 Influenza Virus: Unexpected Rewards from the Past
title_full	Reconstruction of the 1918 Influenza Virus: Unexpected Rewards from the Past
title_fullStr	Reconstruction of the 1918 Influenza Virus: Unexpected Rewards from the Past
title_full_unstemmed	Reconstruction of the 1918 Influenza Virus: Unexpected Rewards from the Past
title_sort	reconstruction of the 1918 influenza virus: unexpected rewards from the past
publisher	American Society for Microbiology
publishDate	2012
url	https://doaj.org/article/a2f5c05465ae4e928f2819aace84c8dd
work_keys_str_mv	AT jefferyktaubenberger reconstructionofthe1918influenzavirusunexpectedrewardsfromthepast AT davidbaltimore reconstructionofthe1918influenzavirusunexpectedrewardsfromthepast AT petercdoherty reconstructionofthe1918influenzavirusunexpectedrewardsfromthepast AT howardmarkel reconstructionofthe1918influenzavirusunexpectedrewardsfromthepast AT davidmmorens reconstructionofthe1918influenzavirusunexpectedrewardsfromthepast AT robertgwebster reconstructionofthe1918influenzavirusunexpectedrewardsfromthepast AT ianawilson reconstructionofthe1918influenzavirusunexpectedrewardsfromthepast
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Reconstruction of the 1918 Influenza Virus: Unexpected Rewards from the Past

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