Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19

Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19

Background: SARS-CoV-2, the virus responsible for COVID-19, causes widespread damage in the lungs in the setting of an overzealous immune response whose origin remains unclear. Methods: We present a scalable, propagable, personalized, cost-effective adult stem cell-derived human lung organoid model...

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Détails bibliographiques
Auteurs principaux: Courtney Tindle, MacKenzie Fuller, Ayden Fonseca, Sahar Taheri, Stella-Rita Ibeawuchi, Nathan Beutler, Gajanan Dattatray Katkar, Amanraj Claire, Vanessa Castillo, Moises Hernandez, Hana Russo, Jason Duran, Laura E Crotty Alexander, Ann Tipps, Grace Lin, Patricia A Thistlethwaite, Ranajoy Chattopadhyay, Thomas F Rogers, Debashis Sahoo, Pradipta Ghosh, Soumita Das
Format: article
Langue:EN
Publié: eLife Sciences Publications Ltd 2021
Sujets:
lung organoid
SARS-CoV2
disease modeling
computational
immune response
AT2 differentiation
Medicine
R
Science
Q
Biology (General)
QH301-705.5
Accès en ligne:https://doaj.org/article/a2f6ea2e6df643eab8feb143e8860634
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