Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin
Osteocytes reside in a low oxygen environment, but it is not clear if oxygen sensing regulates their function. Here, the authors show that deletion of the oxygen sensor prolyl hydroxylase 2 in osteocytes leads to increased bone mass via regulation of sclerostin, and reduces bone loss in mouse models...
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Nature Portfolio
2018
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oai:doaj.org-article:a2f76a4ad04d47d2b0409ff2a91de7402021-12-02T14:41:16ZOsteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin10.1038/s41467-018-04679-72041-1723https://doaj.org/article/a2f76a4ad04d47d2b0409ff2a91de7402018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04679-7https://doaj.org/toc/2041-1723Osteocytes reside in a low oxygen environment, but it is not clear if oxygen sensing regulates their function. Here, the authors show that deletion of the oxygen sensor prolyl hydroxylase 2 in osteocytes leads to increased bone mass via regulation of sclerostin, and reduces bone loss in mouse models of osteoporosis.Steve StegenIngrid StockmansKaren MoermansBernard ThienpontPatrick H. MaxwellPeter CarmelietGeert CarmelietNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018) |
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Science Q Steve Stegen Ingrid Stockmans Karen Moermans Bernard Thienpont Patrick H. Maxwell Peter Carmeliet Geert Carmeliet Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin |
description |
Osteocytes reside in a low oxygen environment, but it is not clear if oxygen sensing regulates their function. Here, the authors show that deletion of the oxygen sensor prolyl hydroxylase 2 in osteocytes leads to increased bone mass via regulation of sclerostin, and reduces bone loss in mouse models of osteoporosis. |
format |
article |
author |
Steve Stegen Ingrid Stockmans Karen Moermans Bernard Thienpont Patrick H. Maxwell Peter Carmeliet Geert Carmeliet |
author_facet |
Steve Stegen Ingrid Stockmans Karen Moermans Bernard Thienpont Patrick H. Maxwell Peter Carmeliet Geert Carmeliet |
author_sort |
Steve Stegen |
title |
Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin |
title_short |
Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin |
title_full |
Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin |
title_fullStr |
Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin |
title_full_unstemmed |
Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin |
title_sort |
osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/a2f76a4ad04d47d2b0409ff2a91de740 |
work_keys_str_mv |
AT stevestegen osteocyticoxygensensingcontrolsbonemassthroughepigeneticregulationofsclerostin AT ingridstockmans osteocyticoxygensensingcontrolsbonemassthroughepigeneticregulationofsclerostin AT karenmoermans osteocyticoxygensensingcontrolsbonemassthroughepigeneticregulationofsclerostin AT bernardthienpont osteocyticoxygensensingcontrolsbonemassthroughepigeneticregulationofsclerostin AT patrickhmaxwell osteocyticoxygensensingcontrolsbonemassthroughepigeneticregulationofsclerostin AT petercarmeliet osteocyticoxygensensingcontrolsbonemassthroughepigeneticregulationofsclerostin AT geertcarmeliet osteocyticoxygensensingcontrolsbonemassthroughepigeneticregulationofsclerostin |
_version_ |
1718389950061215744 |