Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin

Osteocytes reside in a low oxygen environment, but it is not clear if oxygen sensing regulates their function. Here, the authors show that deletion of the oxygen sensor prolyl hydroxylase 2 in osteocytes leads to increased bone mass via regulation of sclerostin, and reduces bone loss in mouse models...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Steve Stegen, Ingrid Stockmans, Karen Moermans, Bernard Thienpont, Patrick H. Maxwell, Peter Carmeliet, Geert Carmeliet
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Q
Acceso en línea:https://doaj.org/article/a2f76a4ad04d47d2b0409ff2a91de740
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:a2f76a4ad04d47d2b0409ff2a91de740
record_format dspace
spelling oai:doaj.org-article:a2f76a4ad04d47d2b0409ff2a91de7402021-12-02T14:41:16ZOsteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin10.1038/s41467-018-04679-72041-1723https://doaj.org/article/a2f76a4ad04d47d2b0409ff2a91de7402018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04679-7https://doaj.org/toc/2041-1723Osteocytes reside in a low oxygen environment, but it is not clear if oxygen sensing regulates their function. Here, the authors show that deletion of the oxygen sensor prolyl hydroxylase 2 in osteocytes leads to increased bone mass via regulation of sclerostin, and reduces bone loss in mouse models of osteoporosis.Steve StegenIngrid StockmansKaren MoermansBernard ThienpontPatrick H. MaxwellPeter CarmelietGeert CarmelietNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Steve Stegen
Ingrid Stockmans
Karen Moermans
Bernard Thienpont
Patrick H. Maxwell
Peter Carmeliet
Geert Carmeliet
Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin
description Osteocytes reside in a low oxygen environment, but it is not clear if oxygen sensing regulates their function. Here, the authors show that deletion of the oxygen sensor prolyl hydroxylase 2 in osteocytes leads to increased bone mass via regulation of sclerostin, and reduces bone loss in mouse models of osteoporosis.
format article
author Steve Stegen
Ingrid Stockmans
Karen Moermans
Bernard Thienpont
Patrick H. Maxwell
Peter Carmeliet
Geert Carmeliet
author_facet Steve Stegen
Ingrid Stockmans
Karen Moermans
Bernard Thienpont
Patrick H. Maxwell
Peter Carmeliet
Geert Carmeliet
author_sort Steve Stegen
title Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin
title_short Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin
title_full Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin
title_fullStr Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin
title_full_unstemmed Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin
title_sort osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/a2f76a4ad04d47d2b0409ff2a91de740
work_keys_str_mv AT stevestegen osteocyticoxygensensingcontrolsbonemassthroughepigeneticregulationofsclerostin
AT ingridstockmans osteocyticoxygensensingcontrolsbonemassthroughepigeneticregulationofsclerostin
AT karenmoermans osteocyticoxygensensingcontrolsbonemassthroughepigeneticregulationofsclerostin
AT bernardthienpont osteocyticoxygensensingcontrolsbonemassthroughepigeneticregulationofsclerostin
AT patrickhmaxwell osteocyticoxygensensingcontrolsbonemassthroughepigeneticregulationofsclerostin
AT petercarmeliet osteocyticoxygensensingcontrolsbonemassthroughepigeneticregulationofsclerostin
AT geertcarmeliet osteocyticoxygensensingcontrolsbonemassthroughepigeneticregulationofsclerostin
_version_ 1718389950061215744