The induction of preterm labor in rhesus macaques is determined by the strength of immune response to intrauterine infection.

Intrauterine infection/inflammation (IUI) is a major contributor to preterm labor (PTL). However, IUI does not invariably cause PTL. We hypothesized that quantitative and qualitative differences in immune response exist in subjects with or without PTL. To define the triggers for PTL, we developed rh...

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Autores principales:	Monica Cappelletti, Pietro Presicce, Ma Feiyang, Paranthaman Senthamaraikannan, Lisa A Miller, Matteo Pellegrini, Myung S Sim, Alan H Jobe, Senad Divanovic, Sing Sing Way, Claire A Chougnet, Suhas G Kallapur
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a2f9e4054a6a41a2b71f11a0c5742a24
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spelling	oai:doaj.org-article:a2f9e4054a6a41a2b71f11a0c5742a242021-12-02T19:54:37ZThe induction of preterm labor in rhesus macaques is determined by the strength of immune response to intrauterine infection.1544-91731545-788510.1371/journal.pbio.3001385https://doaj.org/article/a2f9e4054a6a41a2b71f11a0c5742a242021-09-01T00:00:00Zhttps://doi.org/10.1371/journal.pbio.3001385https://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Intrauterine infection/inflammation (IUI) is a major contributor to preterm labor (PTL). However, IUI does not invariably cause PTL. We hypothesized that quantitative and qualitative differences in immune response exist in subjects with or without PTL. To define the triggers for PTL, we developed rhesus macaque models of IUI driven by lipopolysaccharide (LPS) or live Escherichia coli. PTL did not occur in LPS challenged rhesus macaques, while E. coli-infected animals frequently delivered preterm. Although LPS and live E. coli both caused immune cell infiltration, E. coli-infected animals showed higher levels of inflammatory mediators, particularly interleukin 6 (IL-6) and prostaglandins, in the chorioamnion-decidua and amniotic fluid (AF). Neutrophil infiltration in the chorio-decidua was a common feature to both LPS and E. coli. However, neutrophilic infiltration and IL6 and PTGS2 expression in the amnion was specifically induced by live E. coli. RNA sequencing (RNA-seq) analysis of fetal membranes revealed that specific pathways involved in augmentation of inflammation including type I interferon (IFN) response, chemotaxis, sumoylation, and iron homeostasis were up-regulated in the E. coli group compared to the LPS group. Our data suggest that the intensity of the host immune response to IUI may determine susceptibility to PTL.Monica CappellettiPietro PresicceMa FeiyangParanthaman SenthamaraikannanLisa A MillerMatteo PellegriniMyung S SimAlan H JobeSenad DivanovicSing Sing WayClaire A ChougnetSuhas G KallapurPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 19, Iss 9, p e3001385 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Monica Cappelletti Pietro Presicce Ma Feiyang Paranthaman Senthamaraikannan Lisa A Miller Matteo Pellegrini Myung S Sim Alan H Jobe Senad Divanovic Sing Sing Way Claire A Chougnet Suhas G Kallapur The induction of preterm labor in rhesus macaques is determined by the strength of immune response to intrauterine infection.
description	Intrauterine infection/inflammation (IUI) is a major contributor to preterm labor (PTL). However, IUI does not invariably cause PTL. We hypothesized that quantitative and qualitative differences in immune response exist in subjects with or without PTL. To define the triggers for PTL, we developed rhesus macaque models of IUI driven by lipopolysaccharide (LPS) or live Escherichia coli. PTL did not occur in LPS challenged rhesus macaques, while E. coli-infected animals frequently delivered preterm. Although LPS and live E. coli both caused immune cell infiltration, E. coli-infected animals showed higher levels of inflammatory mediators, particularly interleukin 6 (IL-6) and prostaglandins, in the chorioamnion-decidua and amniotic fluid (AF). Neutrophil infiltration in the chorio-decidua was a common feature to both LPS and E. coli. However, neutrophilic infiltration and IL6 and PTGS2 expression in the amnion was specifically induced by live E. coli. RNA sequencing (RNA-seq) analysis of fetal membranes revealed that specific pathways involved in augmentation of inflammation including type I interferon (IFN) response, chemotaxis, sumoylation, and iron homeostasis were up-regulated in the E. coli group compared to the LPS group. Our data suggest that the intensity of the host immune response to IUI may determine susceptibility to PTL.
format	article
author	Monica Cappelletti Pietro Presicce Ma Feiyang Paranthaman Senthamaraikannan Lisa A Miller Matteo Pellegrini Myung S Sim Alan H Jobe Senad Divanovic Sing Sing Way Claire A Chougnet Suhas G Kallapur
author_facet	Monica Cappelletti Pietro Presicce Ma Feiyang Paranthaman Senthamaraikannan Lisa A Miller Matteo Pellegrini Myung S Sim Alan H Jobe Senad Divanovic Sing Sing Way Claire A Chougnet Suhas G Kallapur
author_sort	Monica Cappelletti
title	The induction of preterm labor in rhesus macaques is determined by the strength of immune response to intrauterine infection.
title_short	The induction of preterm labor in rhesus macaques is determined by the strength of immune response to intrauterine infection.
title_full	The induction of preterm labor in rhesus macaques is determined by the strength of immune response to intrauterine infection.
title_fullStr	The induction of preterm labor in rhesus macaques is determined by the strength of immune response to intrauterine infection.
title_full_unstemmed	The induction of preterm labor in rhesus macaques is determined by the strength of immune response to intrauterine infection.
title_sort	induction of preterm labor in rhesus macaques is determined by the strength of immune response to intrauterine infection.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/a2f9e4054a6a41a2b71f11a0c5742a24
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The induction of preterm labor in rhesus macaques is determined by the strength of immune response to intrauterine infection.

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