Immunoregulatory function of Dictyophora echinovolvata spore polysaccharides in immunocompromised mice induced by cyclophosphamide

The purpose of this study was to investigate whether the Dictyophora echinovolvata spore polysaccharides (DESP) affect the immunity in immunocompromised mice induced by cyclophosphamide (CTX). The healthy female Kunming mice were randomly divided into six groups, including a normal control (NC) grou...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lin Chenqiang, Zhang Hui, Chen Longjun, Fang Yu, Chen Jichen
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	immunomodulatory activity dictyophora echinovolvata spore polysaccharides Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a2fff89d2b984d09b869f355eac0ab95
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a2fff89d2b984d09b869f355eac0ab95
record_format	dspace
spelling	oai:doaj.org-article:a2fff89d2b984d09b869f355eac0ab952021-12-05T14:10:41ZImmunoregulatory function of Dictyophora echinovolvata spore polysaccharides in immunocompromised mice induced by cyclophosphamide2391-541210.1515/biol-2021-0055https://doaj.org/article/a2fff89d2b984d09b869f355eac0ab952021-06-01T00:00:00Zhttps://doi.org/10.1515/biol-2021-0055https://doaj.org/toc/2391-5412The purpose of this study was to investigate whether the Dictyophora echinovolvata spore polysaccharides (DESP) affect the immunity in immunocompromised mice induced by cyclophosphamide (CTX). The healthy female Kunming mice were randomly divided into six groups, including a normal control (NC) group, a positive control group, a model control (MC) group, and three groups treated with low-, intermediate-, and high-dose polysaccharide, respectively. A series of immunoregulatory properties were determined, including humoral and cellular immunity, immune function, and immune factors of mononuclear macrophages. Compared with NC and MC groups, treatment with DESP significantly increased the spleen index and decreased the thymus index; increased the serum concentrations of immunoglobulin (Ig)A, IgG, IgM, hemolysin, IL-1β, and IL-2; delayed the allergic reaction; and improved the splenic lymphocyte transformation ability; and enhanced the phagocytosis of macrophages and the ability to secrete IL-6, TNF-α, caspase-1, and NO with DESP supplementation. These results indicated that DESP might have a good regulatory effect on CTX-induced immunodeficiency in mice, adjust the body’s immune imbalance, and improve the symptoms of low immunity.Lin ChenqiangZhang HuiChen LongjunFang YuChen JichenDe Gruyterarticleimmunomodulatory activitydictyophora echinovolvataspore polysaccharidesBiology (General)QH301-705.5ENOpen Life Sciences, Vol 16, Iss 1, Pp 620-629 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	immunomodulatory activity dictyophora echinovolvata spore polysaccharides Biology (General) QH301-705.5
spellingShingle	immunomodulatory activity dictyophora echinovolvata spore polysaccharides Biology (General) QH301-705.5 Lin Chenqiang Zhang Hui Chen Longjun Fang Yu Chen Jichen Immunoregulatory function of Dictyophora echinovolvata spore polysaccharides in immunocompromised mice induced by cyclophosphamide
description	The purpose of this study was to investigate whether the Dictyophora echinovolvata spore polysaccharides (DESP) affect the immunity in immunocompromised mice induced by cyclophosphamide (CTX). The healthy female Kunming mice were randomly divided into six groups, including a normal control (NC) group, a positive control group, a model control (MC) group, and three groups treated with low-, intermediate-, and high-dose polysaccharide, respectively. A series of immunoregulatory properties were determined, including humoral and cellular immunity, immune function, and immune factors of mononuclear macrophages. Compared with NC and MC groups, treatment with DESP significantly increased the spleen index and decreased the thymus index; increased the serum concentrations of immunoglobulin (Ig)A, IgG, IgM, hemolysin, IL-1β, and IL-2; delayed the allergic reaction; and improved the splenic lymphocyte transformation ability; and enhanced the phagocytosis of macrophages and the ability to secrete IL-6, TNF-α, caspase-1, and NO with DESP supplementation. These results indicated that DESP might have a good regulatory effect on CTX-induced immunodeficiency in mice, adjust the body’s immune imbalance, and improve the symptoms of low immunity.
format	article
author	Lin Chenqiang Zhang Hui Chen Longjun Fang Yu Chen Jichen
author_facet	Lin Chenqiang Zhang Hui Chen Longjun Fang Yu Chen Jichen
author_sort	Lin Chenqiang
title	Immunoregulatory function of Dictyophora echinovolvata spore polysaccharides in immunocompromised mice induced by cyclophosphamide
title_short	Immunoregulatory function of Dictyophora echinovolvata spore polysaccharides in immunocompromised mice induced by cyclophosphamide
title_full	Immunoregulatory function of Dictyophora echinovolvata spore polysaccharides in immunocompromised mice induced by cyclophosphamide
title_fullStr	Immunoregulatory function of Dictyophora echinovolvata spore polysaccharides in immunocompromised mice induced by cyclophosphamide
title_full_unstemmed	Immunoregulatory function of Dictyophora echinovolvata spore polysaccharides in immunocompromised mice induced by cyclophosphamide
title_sort	immunoregulatory function of dictyophora echinovolvata spore polysaccharides in immunocompromised mice induced by cyclophosphamide
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/a2fff89d2b984d09b869f355eac0ab95
work_keys_str_mv	AT linchenqiang immunoregulatoryfunctionofdictyophoraechinovolvatasporepolysaccharidesinimmunocompromisedmiceinducedbycyclophosphamide AT zhanghui immunoregulatoryfunctionofdictyophoraechinovolvatasporepolysaccharidesinimmunocompromisedmiceinducedbycyclophosphamide AT chenlongjun immunoregulatoryfunctionofdictyophoraechinovolvatasporepolysaccharidesinimmunocompromisedmiceinducedbycyclophosphamide AT fangyu immunoregulatoryfunctionofdictyophoraechinovolvatasporepolysaccharidesinimmunocompromisedmiceinducedbycyclophosphamide AT chenjichen immunoregulatoryfunctionofdictyophoraechinovolvatasporepolysaccharidesinimmunocompromisedmiceinducedbycyclophosphamide
_version_	1718371856826761216

Immunoregulatory function of Dictyophora echinovolvata spore polysaccharides in immunocompromised mice induced by cyclophosphamide

Ejemplares similares