Poliovirus-nonsusceptible Vero cell line for the World Health Organization global action plan

Abstract Polio or poliomyelitis is a disabling and life-threatening disease caused by poliovirus (PV). As a consequence of global polio vaccination efforts, wild PV serotypes 2 and 3 have been eradicated around the world, and wild PV serotype 1-transmitted cases have been largely eliminated except f...

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Autores principales:	Yuko Okemoto-Nakamura, Kenji Someya, Toshiyuki Yamaji, Kyoko Saito, Makoto Takeda, Kentaro Hanada
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a301a6f33a664a6aa3a17a5fa620ac77
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spelling	oai:doaj.org-article:a301a6f33a664a6aa3a17a5fa620ac772021-12-02T13:24:26ZPoliovirus-nonsusceptible Vero cell line for the World Health Organization global action plan10.1038/s41598-021-86050-32045-2322https://doaj.org/article/a301a6f33a664a6aa3a17a5fa620ac772021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86050-3https://doaj.org/toc/2045-2322Abstract Polio or poliomyelitis is a disabling and life-threatening disease caused by poliovirus (PV). As a consequence of global polio vaccination efforts, wild PV serotypes 2 and 3 have been eradicated around the world, and wild PV serotype 1-transmitted cases have been largely eliminated except for limited regions. However, vaccine-derived PV, pathogenically reverted live PV vaccine strains, has become a serious issue. For the global eradication of polio, the World Health Organization is conducting the third edition of the Global Action Plan, which is requesting stringent control of potentially PV-infected materials. To facilitate the mission, we generated a PV-nonsusceptible Vero cell subline, which may serve as an ideal replacement of standard Vero cells to isolate emerging/re-emerging viruses without the risk of generating PV-infected materials.Yuko Okemoto-NakamuraKenji SomeyaToshiyuki YamajiKyoko SaitoMakoto TakedaKentaro HanadaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuko Okemoto-Nakamura Kenji Someya Toshiyuki Yamaji Kyoko Saito Makoto Takeda Kentaro Hanada Poliovirus-nonsusceptible Vero cell line for the World Health Organization global action plan
description	Abstract Polio or poliomyelitis is a disabling and life-threatening disease caused by poliovirus (PV). As a consequence of global polio vaccination efforts, wild PV serotypes 2 and 3 have been eradicated around the world, and wild PV serotype 1-transmitted cases have been largely eliminated except for limited regions. However, vaccine-derived PV, pathogenically reverted live PV vaccine strains, has become a serious issue. For the global eradication of polio, the World Health Organization is conducting the third edition of the Global Action Plan, which is requesting stringent control of potentially PV-infected materials. To facilitate the mission, we generated a PV-nonsusceptible Vero cell subline, which may serve as an ideal replacement of standard Vero cells to isolate emerging/re-emerging viruses without the risk of generating PV-infected materials.
format	article
author	Yuko Okemoto-Nakamura Kenji Someya Toshiyuki Yamaji Kyoko Saito Makoto Takeda Kentaro Hanada
author_facet	Yuko Okemoto-Nakamura Kenji Someya Toshiyuki Yamaji Kyoko Saito Makoto Takeda Kentaro Hanada
author_sort	Yuko Okemoto-Nakamura
title	Poliovirus-nonsusceptible Vero cell line for the World Health Organization global action plan
title_short	Poliovirus-nonsusceptible Vero cell line for the World Health Organization global action plan
title_full	Poliovirus-nonsusceptible Vero cell line for the World Health Organization global action plan
title_fullStr	Poliovirus-nonsusceptible Vero cell line for the World Health Organization global action plan
title_full_unstemmed	Poliovirus-nonsusceptible Vero cell line for the World Health Organization global action plan
title_sort	poliovirus-nonsusceptible vero cell line for the world health organization global action plan
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a301a6f33a664a6aa3a17a5fa620ac77
work_keys_str_mv	AT yukookemotonakamura poliovirusnonsusceptibleverocelllinefortheworldhealthorganizationglobalactionplan AT kenjisomeya poliovirusnonsusceptibleverocelllinefortheworldhealthorganizationglobalactionplan AT toshiyukiyamaji poliovirusnonsusceptibleverocelllinefortheworldhealthorganizationglobalactionplan AT kyokosaito poliovirusnonsusceptibleverocelllinefortheworldhealthorganizationglobalactionplan AT makototakeda poliovirusnonsusceptibleverocelllinefortheworldhealthorganizationglobalactionplan AT kentarohanada poliovirusnonsusceptibleverocelllinefortheworldhealthorganizationglobalactionplan
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Poliovirus-nonsusceptible Vero cell line for the World Health Organization global action plan

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