CD146-HIF-1α hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension

CD146-HIF-1α hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension

Vascular remodelling contributes to the development of pulmonary hypertension (PH). Here Luo and colleagues find that increases in CD146 levels drive vascular remodelling in PH through a cross-talk with hypoxia inducible factor (HIF) signalling, and show that inhibition of CD146 can attenuate diseas...

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Autores principales: Yongting Luo, Xiao Teng, Lingling Zhang, Jianan Chen, Zheng Liu, Xuehui Chen, Shuai Zhao, Sai Yang, Jing Feng, Xiyun Yan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/a304de9d8ea444b9a543b37b4f3c7037
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spelling oai:doaj.org-article:a304de9d8ea444b9a543b37b4f3c70372021-12-02T16:58:01ZCD146-HIF-1α hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension10.1038/s41467-019-11500-62041-1723https://doaj.org/article/a304de9d8ea444b9a543b37b4f3c70372019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11500-6https://doaj.org/toc/2041-1723Vascular remodelling contributes to the development of pulmonary hypertension (PH). Here Luo and colleagues find that increases in CD146 levels drive vascular remodelling in PH through a cross-talk with hypoxia inducible factor (HIF) signalling, and show that inhibition of CD146 can attenuate disease progression.Yongting LuoXiao TengLingling ZhangJianan ChenZheng LiuXuehui ChenShuai ZhaoSai YangJing FengXiyun YanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yongting Luo
Xiao Teng
Lingling Zhang
Jianan Chen
Zheng Liu
Xuehui Chen
Shuai Zhao
Sai Yang
Jing Feng
Xiyun Yan
CD146-HIF-1α hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension
description Vascular remodelling contributes to the development of pulmonary hypertension (PH). Here Luo and colleagues find that increases in CD146 levels drive vascular remodelling in PH through a cross-talk with hypoxia inducible factor (HIF) signalling, and show that inhibition of CD146 can attenuate disease progression.
format article
author Yongting Luo
Xiao Teng
Lingling Zhang
Jianan Chen
Zheng Liu
Xuehui Chen
Shuai Zhao
Sai Yang
Jing Feng
Xiyun Yan
author_facet Yongting Luo
Xiao Teng
Lingling Zhang
Jianan Chen
Zheng Liu
Xuehui Chen
Shuai Zhao
Sai Yang
Jing Feng
Xiyun Yan
author_sort Yongting Luo
title CD146-HIF-1α hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension
title_short CD146-HIF-1α hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension
title_full CD146-HIF-1α hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension
title_fullStr CD146-HIF-1α hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension
title_full_unstemmed CD146-HIF-1α hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension
title_sort cd146-hif-1α hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/a304de9d8ea444b9a543b37b4f3c7037
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AT linglingzhang cd146hif1ahypoxicreprogrammingdrivesvascularremodelingandpulmonaryarterialhypertension
AT jiananchen cd146hif1ahypoxicreprogrammingdrivesvascularremodelingandpulmonaryarterialhypertension
AT zhengliu cd146hif1ahypoxicreprogrammingdrivesvascularremodelingandpulmonaryarterialhypertension
AT xuehuichen cd146hif1ahypoxicreprogrammingdrivesvascularremodelingandpulmonaryarterialhypertension
AT shuaizhao cd146hif1ahypoxicreprogrammingdrivesvascularremodelingandpulmonaryarterialhypertension
AT saiyang cd146hif1ahypoxicreprogrammingdrivesvascularremodelingandpulmonaryarterialhypertension
AT jingfeng cd146hif1ahypoxicreprogrammingdrivesvascularremodelingandpulmonaryarterialhypertension
AT xiyunyan cd146hif1ahypoxicreprogrammingdrivesvascularremodelingandpulmonaryarterialhypertension
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