Large-scale genetic investigation reveals genetic liability to multiple complex traits influencing a higher risk of ADHD

Abstract Attention Deficit-Hyperactivity Disorder (ADHD) is a complex psychiatric and neurodevelopmental disorder that develops during childhood and spans into adulthood. ADHD’s aetiology is complex, and evidence about its cause and risk factors is limited. We leveraged genetic data from genome-wide...

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Autores principales:	Luis M. García-Marín, Adrián I. Campos, Gabriel Cuéllar-Partida, Sarah E. Medland, Scott H. Kollins, Miguel E. Rentería
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a30841c8570745abbf49b5cfeb33f0f3
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spelling	oai:doaj.org-article:a30841c8570745abbf49b5cfeb33f0f32021-11-21T12:20:59ZLarge-scale genetic investigation reveals genetic liability to multiple complex traits influencing a higher risk of ADHD10.1038/s41598-021-01517-72045-2322https://doaj.org/article/a30841c8570745abbf49b5cfeb33f0f32021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01517-7https://doaj.org/toc/2045-2322Abstract Attention Deficit-Hyperactivity Disorder (ADHD) is a complex psychiatric and neurodevelopmental disorder that develops during childhood and spans into adulthood. ADHD’s aetiology is complex, and evidence about its cause and risk factors is limited. We leveraged genetic data from genome-wide association studies (GWAS) and performed latent causal variable analyses using a hypothesis-free approach to infer causal associations between 1387 complex traits and ADHD. We identified 37 inferred potential causal associations with ADHD risk. Our results reveal that genetic variants associated with iron deficiency anemia (ICD10), obesity, type 2 diabetes, synovitis and tenosynovitis (ICD10), polyarthritis (ICD10), neck or shoulder pain, and substance use in adults display partial genetic causality on ADHD risk in children. Genetic variants associated with ADHD have a partial genetic causality increasing the risk for chronic obstructive pulmonary disease and carpal tunnel syndrome. Protective factors for ADHD risk included genetic variants associated with the likelihood of participating in socially supportive and interactive activities. Our results show that genetic liability to multiple complex traits influences a higher risk for ADHD, highlighting the potential role of cardiometabolic phenotypes and physical pain in ADHD’s aetiology. These findings have the potential to inform future clinical studies and development of interventions.Luis M. García-MarínAdrián I. CamposGabriel Cuéllar-PartidaSarah E. MedlandScott H. KollinsMiguel E. RenteríaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Luis M. García-Marín Adrián I. Campos Gabriel Cuéllar-Partida Sarah E. Medland Scott H. Kollins Miguel E. Rentería Large-scale genetic investigation reveals genetic liability to multiple complex traits influencing a higher risk of ADHD
description	Abstract Attention Deficit-Hyperactivity Disorder (ADHD) is a complex psychiatric and neurodevelopmental disorder that develops during childhood and spans into adulthood. ADHD’s aetiology is complex, and evidence about its cause and risk factors is limited. We leveraged genetic data from genome-wide association studies (GWAS) and performed latent causal variable analyses using a hypothesis-free approach to infer causal associations between 1387 complex traits and ADHD. We identified 37 inferred potential causal associations with ADHD risk. Our results reveal that genetic variants associated with iron deficiency anemia (ICD10), obesity, type 2 diabetes, synovitis and tenosynovitis (ICD10), polyarthritis (ICD10), neck or shoulder pain, and substance use in adults display partial genetic causality on ADHD risk in children. Genetic variants associated with ADHD have a partial genetic causality increasing the risk for chronic obstructive pulmonary disease and carpal tunnel syndrome. Protective factors for ADHD risk included genetic variants associated with the likelihood of participating in socially supportive and interactive activities. Our results show that genetic liability to multiple complex traits influences a higher risk for ADHD, highlighting the potential role of cardiometabolic phenotypes and physical pain in ADHD’s aetiology. These findings have the potential to inform future clinical studies and development of interventions.
format	article
author	Luis M. García-Marín Adrián I. Campos Gabriel Cuéllar-Partida Sarah E. Medland Scott H. Kollins Miguel E. Rentería
author_facet	Luis M. García-Marín Adrián I. Campos Gabriel Cuéllar-Partida Sarah E. Medland Scott H. Kollins Miguel E. Rentería
author_sort	Luis M. García-Marín
title	Large-scale genetic investigation reveals genetic liability to multiple complex traits influencing a higher risk of ADHD
title_short	Large-scale genetic investigation reveals genetic liability to multiple complex traits influencing a higher risk of ADHD
title_full	Large-scale genetic investigation reveals genetic liability to multiple complex traits influencing a higher risk of ADHD
title_fullStr	Large-scale genetic investigation reveals genetic liability to multiple complex traits influencing a higher risk of ADHD
title_full_unstemmed	Large-scale genetic investigation reveals genetic liability to multiple complex traits influencing a higher risk of ADHD
title_sort	large-scale genetic investigation reveals genetic liability to multiple complex traits influencing a higher risk of adhd
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a30841c8570745abbf49b5cfeb33f0f3
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Large-scale genetic investigation reveals genetic liability to multiple complex traits influencing a higher risk of ADHD

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