Genetic Contributions to Prostate Cancer Disparities in Men of West African Descent

Prostate cancer (PCa) is the second most frequently diagnosed malignancy and the second leading cause of death in men worldwide, after adjusting for age. According to the International Agency for Research on Cancer, continents such as North America and Europe report higher incidence of PCa; however,...

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Autores principales:	Jabril R. Johnson, Leanne Woods-Burnham, Stanley E. Hooker, Ken Batai, Rick A. Kittles
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	genetics prostate cancer genetics prostate cancer disparities GWAS Vitamin D prostate cancer screening Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/a30a4c20aea04e85a69afc5db9f2fff8
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spelling	oai:doaj.org-article:a30a4c20aea04e85a69afc5db9f2fff82021-11-08T07:03:53ZGenetic Contributions to Prostate Cancer Disparities in Men of West African Descent2234-943X10.3389/fonc.2021.770500https://doaj.org/article/a30a4c20aea04e85a69afc5db9f2fff82021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.770500/fullhttps://doaj.org/toc/2234-943XProstate cancer (PCa) is the second most frequently diagnosed malignancy and the second leading cause of death in men worldwide, after adjusting for age. According to the International Agency for Research on Cancer, continents such as North America and Europe report higher incidence of PCa; however, mortality rates are highest among men of African ancestry in the western, southern, and central regions of Africa and the Caribbean. The American Cancer Society reports, African Americans (AAs), in the United States, have a 1.7 increased incidence and 2.4 times higher mortality rate, compared to European American’s (EAs). Hence, early population history in west Africa and the subsequent African Diaspora may play an important role in understanding the global disproportionate burden of PCa shared among Africans and other men of African descent. Nonetheless, disparities involved in diagnosis, treatment, and survival of PCa patients has also been correlated to socioeconomic status, education and access to healthcare. Although recent studies suggest equal PCa treatments yield equal outcomes among patients, data illuminates an unsettling reality of disparities in treatment and care in both, developed and developing countries, especially for men of African descent. Yet, even after adjusting for the effects of the aforementioned factors; racial disparities in mortality rates remain significant. This suggests that molecular and genomic factors may account for much of PCa disparities.Jabril R. JohnsonLeanne Woods-BurnhamStanley E. HookerKen BataiRick A. KittlesFrontiers Media S.A.articlegeneticsprostate cancer geneticsprostate cancer disparitiesGWASVitamin Dprostate cancer screeningNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	genetics prostate cancer genetics prostate cancer disparities GWAS Vitamin D prostate cancer screening Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	genetics prostate cancer genetics prostate cancer disparities GWAS Vitamin D prostate cancer screening Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Jabril R. Johnson Leanne Woods-Burnham Stanley E. Hooker Ken Batai Rick A. Kittles Genetic Contributions to Prostate Cancer Disparities in Men of West African Descent
description	Prostate cancer (PCa) is the second most frequently diagnosed malignancy and the second leading cause of death in men worldwide, after adjusting for age. According to the International Agency for Research on Cancer, continents such as North America and Europe report higher incidence of PCa; however, mortality rates are highest among men of African ancestry in the western, southern, and central regions of Africa and the Caribbean. The American Cancer Society reports, African Americans (AAs), in the United States, have a 1.7 increased incidence and 2.4 times higher mortality rate, compared to European American’s (EAs). Hence, early population history in west Africa and the subsequent African Diaspora may play an important role in understanding the global disproportionate burden of PCa shared among Africans and other men of African descent. Nonetheless, disparities involved in diagnosis, treatment, and survival of PCa patients has also been correlated to socioeconomic status, education and access to healthcare. Although recent studies suggest equal PCa treatments yield equal outcomes among patients, data illuminates an unsettling reality of disparities in treatment and care in both, developed and developing countries, especially for men of African descent. Yet, even after adjusting for the effects of the aforementioned factors; racial disparities in mortality rates remain significant. This suggests that molecular and genomic factors may account for much of PCa disparities.
format	article
author	Jabril R. Johnson Leanne Woods-Burnham Stanley E. Hooker Ken Batai Rick A. Kittles
author_facet	Jabril R. Johnson Leanne Woods-Burnham Stanley E. Hooker Ken Batai Rick A. Kittles
author_sort	Jabril R. Johnson
title	Genetic Contributions to Prostate Cancer Disparities in Men of West African Descent
title_short	Genetic Contributions to Prostate Cancer Disparities in Men of West African Descent
title_full	Genetic Contributions to Prostate Cancer Disparities in Men of West African Descent
title_fullStr	Genetic Contributions to Prostate Cancer Disparities in Men of West African Descent
title_full_unstemmed	Genetic Contributions to Prostate Cancer Disparities in Men of West African Descent
title_sort	genetic contributions to prostate cancer disparities in men of west african descent
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a30a4c20aea04e85a69afc5db9f2fff8
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Genetic Contributions to Prostate Cancer Disparities in Men of West African Descent

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